Motif ID: GUCAGUU

Z-value: 0.786


Mature miRNA associated with seed GUCAGUU:

NamemiRBase Accession
hsa-miR-223 MIMAT0000280



Activity profile for motif GUCAGUU.

activity profile for motif GUCAGUU


Sorted Z-values histogram for motif GUCAGUU

Sorted Z-values for motif GUCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUCAGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_99801365 6.859 NM_001333
CTSL2
cathepsin L2
chr9_-_99801924 6.663 NM_001201575
CTSL2
cathepsin L2
chr17_-_19770988 4.546 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr4_-_99579540 4.361 NM_005723
TSPAN5
tetraspanin 5
chr5_+_140254930 4.250 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr17_+_19437140 4.013 NM_018242
SLC47A1
solute carrier family 47, member 1
chr19_-_37701385 3.912 NM_152279
ZNF585B
zinc finger protein 585B
chr19_-_37663567 3.805 NM_152655
ZNF585A
zinc finger protein 585A
chr5_-_1112106 3.650 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chrX_-_64196268 3.645 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr7_+_89840999 3.187 NM_001244944
NM_001244945
NM_152999
NM_001040665
NM_001244946
STEAP2




STEAP family member 2, metalloreductase




chr2_-_86564632 2.757 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr19_-_19932512 2.627 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chr6_+_13925097 2.598 NM_001165032
NM_152737
RNF182

ring finger protein 182

chrX_-_64254592 2.459 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr19_-_37663332 2.355 NM_199126
ZNF585A
zinc finger protein 585A
chr5_+_140247767 2.229 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr6_+_13925423 2.158 NM_001165033
RNF182
ring finger protein 182
chr5_+_140777603 2.145 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr2_+_150187028 2.039 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr11_+_66790815 2.034 NM_177963
SYT12
synaptotagmin XII
chr10_+_94449678 1.976 NM_002729
HHEX
hematopoietically expressed homeobox
chr5_+_140165875 1.924 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr2_+_150186498 1.911 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr6_+_106546736 1.846 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr7_-_82792127 1.808 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr5_+_140235594 1.797 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr6_+_106534188 1.771 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr5_+_140345746 1.769 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr10_+_112404104 1.764 NM_001134363
RBM20
RNA binding motif protein 20
chr14_-_94254765 1.722 NM_178013
PRIMA1
proline rich membrane anchor 1
chr11_+_130318457 1.698 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr6_-_46138584 1.687 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr14_-_75078669 1.652 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr11_-_33913835 1.606 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_+_140306301 1.598 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr5_-_115910406 1.583 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_-_108507474 1.577 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr5_+_140207562 1.536 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr5_+_140180782 1.520 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr11_+_66790189 1.516 NM_001177880
SYT12
synaptotagmin XII
chr19_-_57988891 1.509 NM_001024596
NM_001144068
ZNF772

zinc finger protein 772

chr10_-_30348433 1.493 NM_020848
KIAA1462
KIAA1462
chr11_-_33891361 1.472 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_+_71403040 1.457 NM_005909
MAP1B
microtubule-associated protein 1B
chr11_-_58343308 1.453 NM_004811
LPXN
leupaxin
chr1_-_52456292 1.417 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr5_+_140186658 1.413 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr11_-_58345593 1.409 NM_001143995
LPXN
leupaxin
chr2_-_40657419 1.400 NM_001112800
NM_001112801
NM_001252624
NM_021097
SLC8A1



solute carrier family 8 (sodium/calcium exchanger), member 1



chr5_+_140201221 1.399 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr11_-_33891485 1.398 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_+_140220811 1.360 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr11_+_73358593 1.358 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chrX_+_135278912 1.356 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chrX_+_135229536 1.353 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr1_-_1535446 1.338 NM_001242659
LOC643988
uncharacterized LOC643988
chr3_-_33260706 1.338 NM_015551
SUSD5
sushi domain containing 5
chr5_-_136834887 1.336 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr12_-_22487566 1.330 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr1_-_108231122 1.317 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_186649421 1.315 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_70346113 1.307 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr5_+_140213968 1.296 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr6_+_13924676 1.291 NM_001165034
RNF182
ring finger protein 182
chr2_-_86565205 1.283 NM_001164730
REEP1
receptor accessory protein 1
chr15_+_84322809 1.218 NM_207517
ADAMTSL3
ADAMTS-like 3
chr1_+_247581350 1.177 NM_001127462
NM_001243133
NM_004895
NM_183395
NLRP3



NLR family, pyrin domain containing 3



chrX_+_135230736 1.163 NM_001159700
FHL1
four and a half LIM domains 1
chr11_-_74109417 1.158 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr1_-_51810693 1.130 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr14_-_94856926 1.106 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr8_+_97505876 1.106 NM_002998
SDC2
syndecan 2
chr1_-_221915458 1.096 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr12_+_72666462 1.087 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr7_-_105319608 1.081 NM_138495
ATXN7L1
ataxin 7-like 1
chr17_-_78450247 1.053 NM_002522
NPTX1
neuronal pentraxin I
chr3_-_171528227 1.034 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr3_-_124774735 1.025 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr14_-_94855120 1.021 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_221910801 1.008 NM_144728
DUSP10
dual specificity phosphatase 10
chr2_-_227663454 1.002 NM_005544
IRS1
insulin receptor substrate 1
chr9_-_16870719 0.992 NM_017637
BNC2
basonuclin 2
chr12_+_79258448 0.984 NM_005639
SYT1
synaptotagmin I
chr8_-_95961543 0.981 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr12_+_72233486 0.980 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr1_+_1370902 0.977 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr1_+_247579457 0.973 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr5_-_158636489 0.959 NM_001199383
RNF145
ring finger protein 145
chr1_+_78956727 0.957 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr2_-_110371669 0.957 NM_144710
NM_178584
SEPT10

septin 10

chr12_+_79257772 0.954 NM_001135805
SYT1
synaptotagmin I
chr12_+_79439432 0.947 NM_001135806
SYT1
synaptotagmin I
chr15_+_32322690 0.944 NM_000746
NM_001190455
CHRNA7

cholinergic receptor, nicotinic, alpha 7

chr1_-_145075636 0.943 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_51787881 0.941 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr1_+_74701070 0.941 NM_015978
TNNI3K
TNNI3 interacting kinase
chrX_+_135251454 0.935 NM_001159704
FHL1
four and a half LIM domains 1
chr2_+_149632772 0.934 NM_004522
KIF5C
kinesin family member 5C
chr16_+_19422056 0.930 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr5_-_121414011 0.928 NM_002317
LOX
lysyl oxidase
chr5_-_158637060 0.926 NM_001199380
RNF145
ring finger protein 145
chr12_+_56732658 0.924 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr5_-_121412805 0.920 NM_001178102
LOX
lysyl oxidase
chr5_-_137071703 0.918 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr1_+_204797774 0.914 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chrX_+_135251795 0.914 NM_001167819
FHL1
four and a half LIM domains 1
chr11_-_16430425 0.913 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr17_+_2699731 0.904 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr16_+_19467771 0.883 NM_024780
TMC5
transmembrane channel-like 5
chr5_+_140767402 0.880 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr5_+_140810126 0.871 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr1_-_182361311 0.864 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr12_-_54673901 0.864 NM_012117
CBX5
chromobox homolog 5
chr3_-_47620186 0.861 NM_001206943
NM_001206944
NM_006574
CSPG5


chondroitin sulfate proteoglycan 5 (neuroglycan C)


chr1_-_182360400 0.857 NM_001033056
GLUL
glutamate-ammonia ligase
chr9_-_14398981 0.850 NM_001190738
NFIB
nuclear factor I/B
chr17_+_57408907 0.846 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr1_+_164528586 0.840 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr18_+_42260774 0.831 NM_015559
SETBP1
SET binding protein 1
chr10_+_104503724 0.822 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr1_+_205538111 0.817 NM_181644
MFSD4
major facilitator superfamily domain containing 4
chr3_-_71774407 0.816 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr1_+_204913353 0.812 NM_001160331
NFASC
neurofascin
chr18_-_28622624 0.810 NM_001941
NM_024423
DSC3

desmocollin 3

chr15_-_40398286 0.798 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr5_+_140261792 0.797 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr17_+_70117154 0.795 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr9_-_14314036 0.782 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr7_-_112726143 0.768 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr8_-_67525426 0.760 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

uncharacterized LOC645895
chr2_-_26205437 0.758 NM_002254
KIF3C
kinesin family member 3C
chr11_-_16497917 0.758 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr3_+_119421865 0.754 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr6_-_36355342 0.753 NM_001207038
NM_001207035
NM_001207036
NM_001207037
NM_001207039
NM_001207040
NM_001207041
NM_016135
ETV7







ets variant 7







chr16_+_8768403 0.740 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr4_-_90759446 0.737 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_-_144997110 0.718 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr22_-_38577692 0.716 NM_001004426
NM_003560
NM_001199562
PLA2G6


phospholipase A2, group VI (cytosolic, calcium-independent)


chr4_-_90758126 0.715 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr15_+_99192696 0.714 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr17_+_40439564 0.714 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr12_+_133707212 0.711 NM_015394
ZNF10
zinc finger protein 10
chr1_-_21059132 0.711 NM_001103160
NM_001103161
SH2D5

SH2 domain containing 5

chr3_-_47621729 0.702 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chrX_+_12993224 0.699 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr15_-_40398573 0.698 NM_033503
BMF
Bcl2 modifying factor
chr11_+_73357222 0.686 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_99079017 0.686 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr10_+_82168206 0.682 NM_001243780
NM_001243781
NM_032333
C10orf58


chromosome 10 open reading frame 58


chr3_-_57199402 0.671 NM_017563
IL17RD
interleukin 17 receptor D
chr2_-_178483677 0.670 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr18_+_51885170 0.670 NM_173529
C18orf54
chromosome 18 open reading frame 54
chr5_-_132948222 0.669 NM_015082
FSTL4
follistatin-like 4
chr5_+_140174443 0.665 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr20_-_9819406 0.654 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr5_-_158634833 0.649 NM_144726
RNF145
ring finger protein 145
chr6_-_79787939 0.648 NM_017934
PHIP
pleckstrin homology domain interacting protein
chr1_-_214724974 0.634 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr15_-_40401041 0.633 NM_001003940
BMF
Bcl2 modifying factor
chr3_-_71803923 0.624 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr5_-_158635080 0.623 NM_001199381
RNF145
ring finger protein 145
chr4_-_25161908 0.622 NM_016955
SEPSECS
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr5_-_9546157 0.614 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr16_+_8814567 0.612 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr8_-_18871163 0.610 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_145277879 0.598 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr16_+_8806825 0.598 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr22_-_39548448 0.595 NM_175709
CBX7
chromobox homolog 7
chr1_+_42846427 0.574 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr22_-_39240016 0.572 NM_014293
NPTXR
neuronal pentraxin receptor
chrX_+_57618268 0.561 NM_007157
ZXDB
zinc finger, X-linked, duplicated B
chr16_+_30960377 0.553 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chr13_+_44453968 0.552 NM_153218
LACC1
laccase (multicopper oxidoreductase) domain containing 1
chr17_-_8066254 0.535 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr9_-_27529434 0.531 NM_024761
MOB3B
MOB kinase activator 3B
chr4_-_175205401 0.530 NM_012180
FBXO8
F-box protein 8
chr14_+_32798478 0.528 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr5_+_140718353 0.522 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr14_-_80677839 0.516 NM_001007023
NM_001242502
NM_001242503
NM_013989
DIO2



deiodinase, iodothyronine, type II



chr12_-_21654484 0.516 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr11_+_14665268 0.515 NM_000922
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr9_-_123639566 0.513 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr7_-_130080823 0.513 NM_018718
CEP41
centrosomal protein 41kDa
chr7_-_14025826 0.511 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr6_-_39693110 0.509 NM_145027
KIF6
kinesin family member 6
chr14_+_38677186 0.503 NM_001049
SSTR1
somatostatin receptor 1
chr10_-_61122219 0.496 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr3_-_71803513 0.495 NM_001134649
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr10_-_123353771 0.489 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr1_-_48462561 0.488 NM_001194986
LOC388630
UPF0632 protein A
chr7_+_29846112 0.487 NM_001080529
WIPF3
WAS/WASL interacting protein family, member 3
chrX_+_53449804 0.486 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chr13_-_110438896 0.482 NM_003749
IRS2
insulin receptor substrate 2
chr2_+_203499819 0.482 NM_173511
FAM117B
family with sequence similarity 117, member B
chr10_+_97889467 0.482 NM_014803
ZNF518A
zinc finger protein 518A
chr3_-_184870727 0.481 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr5_+_140729723 0.477 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr13_-_77460432 0.476 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr1_+_118148506 0.467 NM_017709
FAM46C
family with sequence similarity 46, member C

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
26.62 4.64e-13 GO:0007156 homophilic cell adhesion
12.51 8.00e-09 GO:0016337 cell-cell adhesion
6.29 8.23e-07 GO:0007155 cell adhesion
6.29 8.23e-07 GO:0022610 biological adhesion
4.06 1.01e-05 GO:0007399 nervous system development
2.65 5.05e-04 GO:0048731 system development
2.35 1.60e-03 GO:0007275 multicellular organismal development
2.38 3.65e-03 GO:0048856 anatomical structure development
268.06 4.73e-03 GO:0031915 positive regulation of synaptic plasticity
2.14 9.68e-03 GO:0032502 developmental process
42.34 1.57e-02 GO:0001893 maternal placenta development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.88 7.11e-05 GO:0031226 intrinsic to plasma membrane
2.17 2.59e-04 GO:0005886 plasma membrane
3.72 2.80e-04 GO:0005887 integral to plasma membrane
2.14 3.57e-04 GO:0071944 cell periphery
2.78 6.15e-04 GO:0044459 plasma membrane part
1.61 3.82e-02 GO:0044425 membrane part
1.70 4.68e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.70 4.84e-10 GO:0005509 calcium ion binding
2.64 5.17e-08 GO:0046872 metal ion binding
2.61 7.14e-08 GO:0043169 cation binding
2.61 7.67e-08 GO:0043167 ion binding