Motif ID: GUAACAG

Z-value: 0.410


Mature miRNA associated with seed GUAACAG:

NamemiRBase Accession
hsa-miR-194 MIMAT0000460



Activity profile for motif GUAACAG.

activity profile for motif GUAACAG


Sorted Z-values histogram for motif GUAACAG

Sorted Z-values for motif GUAACAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAACAG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_19837599 1.177 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr8_-_11324184 1.120 NM_053279
FAM167A
family with sequence similarity 167, member A
chr22_-_30642683 1.069 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr5_-_139726173 1.029 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr2_+_210444364 1.016 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr14_-_38064440 0.964 NM_004496
FOXA1
forkhead box A1
chr2_+_210288668 0.902 NM_001039538
MAP2
microtubule-associated protein 2
chr15_+_62939509 0.900 NM_015059
TLN2
talin 2
chr3_+_152880024 0.880 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr3_-_18466759 0.830 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr3_-_18480203 0.751 NM_001131010
SATB1
SATB homeobox 1
chr4_+_86396251 0.741 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr13_-_41240607 0.729 NM_002015
FOXO1
forkhead box O1
chr11_-_17410205 0.680 NM_000525
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr4_+_87856152 0.667 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr10_-_75634219 0.660 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr4_+_87928083 0.634 NM_005935
AFF1
AF4/FMR2 family, member 1
chr4_+_41614911 0.602 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr14_+_39734475 0.601 NM_203354
CTAGE5
CTAGE family, member 5
chr14_+_39736277 0.580 NM_001247989
NM_001247990
NM_005930
NM_203355
CTAGE5



CTAGE family, member 5



chr15_-_56035176 0.580 NM_173814
PRTG
protogenin
chr4_+_41362750 0.568 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr8_+_102504661 0.550 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr3_+_69915374 0.541 NM_198177
MITF
microphthalmia-associated transcription factor
chr15_-_37390372 0.529 NM_172315
MEIS2
Meis homeobox 2
chr14_+_39735500 0.529 NM_001247988
NM_203356
CTAGE5

CTAGE family, member 5

chr3_-_195808997 0.528 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr16_-_73082169 0.524 NM_006885
ZFHX3
zinc finger homeobox 3
chr10_+_114709963 0.522 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chrX_-_119694719 0.514 NM_001079872
CUL4B
cullin 4B
chr3_-_195808958 0.512 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr3_+_69812961 0.502 NM_006722
MITF
microphthalmia-associated transcription factor
chr16_-_73092533 0.489 NM_001164766
ZFHX3
zinc finger homeobox 3
chrX_-_119709618 0.480 NM_003588
CUL4B
cullin 4B
chr19_-_46272496 0.477 NM_175875
SIX5
SIX homeobox 5
chr4_-_74904329 0.476 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr3_+_69812620 0.475 NM_001184967
MITF
microphthalmia-associated transcription factor
chr18_-_3011944 0.458 NM_014646
LPIN2
lipin 2
chr15_-_37391596 0.453 NM_172316
MEIS2
Meis homeobox 2
chr4_+_86851425 0.439 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr15_-_34629044 0.432 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr14_+_58765209 0.425 NM_002892
NM_023000
NM_023001
ARID4A


AT rich interactive domain 4A (RBP1-like)


chr15_-_37392358 0.424 NM_170674
NM_170675
NM_170676
NM_170677
MEIS2



Meis homeobox 2



chr10_-_64576123 0.417 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr14_+_55221505 0.405 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr10_-_64578926 0.398 NM_001136178
EGR2
early growth response 2
chr3_+_69788562 0.395 NM_198159
MITF
microphthalmia-associated transcription factor
chr5_-_59783885 0.394 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_17410863 0.390 NM_001166290
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr3_+_69985750 0.385 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr15_-_34610928 0.369 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr17_+_35294771 0.367 NM_005568
LHX1
LIM homeobox 1
chr4_-_23891608 0.360 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr3_-_155394104 0.359 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr15_-_37393364 0.355 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr11_-_46142955 0.353 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr9_+_131445933 0.347 NM_001122821
SET
SET nuclear oncogene
chr14_-_100070442 0.344 NM_001144995
CCDC85C
coiled-coil domain containing 85C
chr4_+_37246689 0.338 NM_001144990
KIAA1239
KIAA1239
chr2_-_122406994 0.336 NM_001142273
NM_001142274
NM_001207051
NM_015282
CLASP1



cytoplasmic linker associated protein 1



chr16_+_47495166 0.334 NM_000293
NM_001031835
PHKB

phosphorylase kinase, beta

chr4_+_95679075 0.330 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr5_+_176560056 0.320 NM_172349
NSD1
nuclear receptor binding SET domain protein 1
chr14_+_55034329 0.318 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr6_-_111804413 0.317 NM_002912
REV3L
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
chrX_+_38420690 0.308 NM_004615
TSPAN7
tetraspanin 7
chr2_-_99347588 0.307 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr18_-_74207145 0.307 NM_014643
ZNF516
zinc finger protein 516
chr12_-_31743822 0.307 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr3_-_133614421 0.305 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chrX_+_38663072 0.296 NM_021242
MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr17_+_61699786 0.294 NM_002401
NM_203351
MAP3K3

mitogen-activated protein kinase kinase kinase 3

chr14_+_32546445 0.288 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr14_+_74551655 0.288 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr20_-_25604583 0.288 NM_152667
NANP
N-acetylneuraminic acid phosphatase
chr2_+_203499819 0.279 NM_173511
FAM117B
family with sequence similarity 117, member B
chr12_-_88974094 0.272 NM_000899
NM_003994
KITLG

KIT ligand

chr7_-_107880492 0.271 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr6_-_83903632 0.267 NM_001199917
PGM3
phosphoglucomutase 3
chr18_+_3447607 0.264 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr8_-_116681103 0.264 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr9_-_74979829 0.264 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chr10_-_65028825 0.263 NM_004241
JMJD1C
jumonji domain containing 1C
chr1_+_184356128 0.262 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr3_-_127541975 0.261 NM_001003794
MGLL
monoglyceride lipase
chr2_+_149402559 0.261 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr16_+_30675777 0.260 NM_001105079
FBRS
fibrosin
chr7_+_77167351 0.260 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr5_-_58334936 0.259 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr3_-_127541160 0.257 NM_007283
MGLL
monoglyceride lipase
chr5_+_176560627 0.249 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr5_-_59189620 0.246 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr18_+_3453771 0.240 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr3_-_155421996 0.237 NM_014996
PLCH1
phospholipase C, eta 1
chr15_-_34630203 0.236 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr18_+_3412071 0.234 NM_174886
TGIF1
TGFB-induced factor homeobox 1
chr7_-_94285477 0.229 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr17_-_65241305 0.229 NM_014877
HELZ
helicase with zinc finger
chr10_+_98592658 0.227 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr15_+_96869156 0.226 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr18_+_3451589 0.225 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr6_+_33378772 0.223 NM_002636
NM_024165
PHF1

PHD finger protein 1

chrX_+_38660653 0.222 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chr7_-_108096693 0.220 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr3_-_149688638 0.219 NM_002628
NM_053024
PFN2

profilin 2

chrX_-_71933709 0.213 NM_001122670
NM_001172436
NM_002637
PHKA1


phosphorylase kinase, alpha 1 (muscle)


chr5_-_141704575 0.212 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr5_-_58571916 0.211 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr18_-_25757351 0.211 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr11_+_61520000 0.210 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr10_-_65225605 0.210 NM_032776
JMJD1C
jumonji domain containing 1C
chr18_+_3449972 0.209 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr7_-_152133071 0.206 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr20_-_40246991 0.205 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr14_-_91282760 0.203 NM_001010854
TTC7B
tetratricopeptide repeat domain 7B
chr17_-_33390676 0.202 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr17_-_40428391 0.201 NM_012448
STAT5B
signal transducer and activator of transcription 5B
chr1_+_222791151 0.198 NM_198551
MIA3
melanoma inhibitory activity family, member 3
chr12_-_54653317 0.197 NM_001127322
CBX5
chromobox homolog 5
chr5_-_58295758 0.197 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_59981517 0.194 NM_004330
BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr4_+_86699846 0.192 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr18_+_43753986 0.189 NM_001008239
NM_145055
C18orf25

chromosome 18 open reading frame 25

chr15_-_34629941 0.188 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr17_+_27071008 0.186 NM_004295
TRAF4
TNF receptor-associated factor 4
chr1_-_93646245 0.183 NM_001167830
NM_016040
TMED5

transmembrane emp24 protein transport domain containing 5

chr8_-_28243941 0.181 NM_018660
ZNF395
zinc finger protein 395
chr3_+_197476623 0.179 NM_032288
FYTTD1
forty-two-three domain containing 1
chr7_+_77166750 0.177 NM_002835
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr12_+_56915587 0.173 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr5_-_58882274 0.168 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58652671 0.167 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_139876718 0.163 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr12_-_498428 0.161 NM_001042603
KDM5A
lysine (K)-specific demethylase 5A
chr7_+_141251077 0.160 NM_018238
AGK
acylglycerol kinase
chrX_+_119738542 0.159 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr7_-_100286869 0.156 NM_022574
GIGYF1
GRB10 interacting GYF protein 1
chr3_+_185080835 0.156 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_-_211752052 0.156 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr12_-_54653369 0.154 NM_001127321
CBX5
chromobox homolog 5
chr19_-_40791291 0.151 NM_001243027
NM_001243028
NM_001626
AKT2


v-akt murine thymoma viral oncogene homolog 2


chr16_-_58768132 0.146 NM_002080
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
chr15_+_39873276 0.145 NM_003246
THBS1
thrombospondin 1
chr4_-_6383572 0.145 NM_181876
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr8_-_54755836 0.144 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr2_-_128100673 0.141 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr18_-_29523087 0.140 NM_014939
TRAPPC8
trafficking protein particle complex 8
chr2_-_213403280 0.140 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr16_+_53088791 0.138 NM_025134
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_153958688 0.138 NM_002870
RAB13
RAB13, member RAS oncogene family
chr1_+_109633373 0.138 NM_020141
TMEM167B
transmembrane protein 167B
chr7_-_98741681 0.137 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr11_-_36531767 0.132 NM_004620
NM_145803
TRAF6

TNF receptor-associated factor 6

chr2_+_85198176 0.132 NM_020122
KCMF1
potassium channel modulatory factor 1
chr1_+_52608045 0.132 NM_004799
NM_007323
NM_007324
ZFYVE9


zinc finger, FYVE domain containing 9


chr11_+_61522860 0.132 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr5_-_98262217 0.132 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr3_+_180630054 0.132 NM_001013438
NM_001013439
NM_005087
FXR1


fragile X mental retardation, autosomal homolog 1


chr1_+_179923870 0.131 NM_014810
CEP350
centrosomal protein 350kDa
chr5_+_138678130 0.130 NM_001033112
PAIP2
poly(A) binding protein interacting protein 2
chr9_+_35161950 0.129 NM_006377
UNC13B
unc-13 homolog B (C. elegans)
chr10_+_124768401 0.129 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr3_+_197476423 0.129 NM_001011537
FYTTD1
forty-two-three domain containing 1
chr8_-_54755546 0.128 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr12_+_102271082 0.128 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr6_+_43457214 0.127 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr11_+_74660290 0.125 NM_014752
LOC653566
SPCS2
signal peptidase complex subunit 2 homolog pseudogene
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr1_-_212965104 0.124 NM_001042549
NM_015471
NSL1

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr20_-_43977023 0.123 NM_002999
SDC4
syndecan 4
chr10_+_98592015 0.121 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr3_+_185000714 0.121 NM_001242314
NM_001242317
MAP3K13

mitogen-activated protein kinase kinase kinase 13

chr15_-_59225800 0.120 NM_001013843
NM_024755
SLTM

SAFB-like, transcription modulator

chr3_-_71803923 0.118 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr5_-_168006413 0.118 NM_024594
PANK3
pantothenate kinase 3
chr4_-_140060601 0.118 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chrX_-_13835313 0.118 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr12_+_46123495 0.117 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr19_+_41903693 0.117 NM_000709
NM_001164783
BCKDHA

branched chain keto acid dehydrogenase E1, alpha polypeptide

chr14_+_52327021 0.113 NM_001243773
NM_001243774
NM_053064
GNG2


guanine nucleotide binding protein (G protein), gamma 2


chr15_+_59063389 0.113 NM_001040450
NM_001040453
FAM63B

family with sequence similarity 63, member B

chr17_-_47439326 0.110 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr17_-_73179093 0.109 NM_001005849
NM_006937
SUMO2

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

chr9_+_131451470 0.109 NM_003011
SET
SET nuclear oncogene
chr18_-_23670533 0.107 NM_001007559
NM_005637
SS18

synovial sarcoma translocation, chromosome 18

chr15_+_64388082 0.106 NM_001242933
NM_003099
NM_148955
SNX1


sorting nexin 1


chr12_-_57400199 0.105 NM_014830
ZBTB39
zinc finger and BTB domain containing 39
chr14_-_74253876 0.104 NM_001043318
C14orf43
chromosome 14 open reading frame 43
chr14_-_23755308 0.101 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr5_-_108745569 0.100 NM_014819
PJA2
praja ring finger 2
chr6_+_157802479 0.099 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr21_+_38792600 0.099 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr9_-_4152182 0.097 NM_152629
GLIS3
GLIS family zinc finger 3
chr22_+_31608249 0.097 NM_005569
LIMK2
LIM domain kinase 2
chr22_+_41253055 0.095 NM_001204827
NM_022098
XPNPEP3

X-prolyl aminopeptidase (aminopeptidase P) 3, putative

chrX_-_135338640 0.094 NM_001173516
MAP7D3
MAP7 domain containing 3
chr3_+_14166439 0.093 NM_024334
TMEM43
transmembrane protein 43
chr4_-_6565326 0.092 NM_001206994
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr1_+_236686738 0.091 NM_006499
NM_201543
LGALS8

lectin, galactoside-binding, soluble, 8

chr4_-_6557404 0.088 NM_001206995
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr3_-_71778268 0.087 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
614.27 1.64e-04 GO:0048710 regulation of astrocyte differentiation
241.44 1.13e-03 GO:0045685 regulation of glial cell differentiation
198.87 1.67e-03 GO:0014013 regulation of gliogenesis
21.67 6.07e-03 GO:0008284 positive regulation of cell proliferation
7.20 1.22e-02 GO:0048523 negative regulation of cellular process
6.58 1.77e-02 GO:0048519 negative regulation of biological process
13.87 2.33e-02 GO:0051128 regulation of cellular component organization
11.90 3.69e-02 GO:0042127 regulation of cell proliferation
36.91 4.96e-02 GO:0007517 muscle organ development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
42.68 2.12e-03 GO:0008083 growth factor activity