Motif ID: GTF2I.p2

Z-value: 2.394


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2Ihg19_v1_chr7_+_74072038_740720510.538.9e-07Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51487070 47.822 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chrX_+_152760346 30.761 NM_001711
BGN
biglycan
chr8_-_22549901 27.271 NM_001199880
EGR3
early growth response 3
chr12_-_45270071 23.965 NELL2
NEL-like 2 (chicken)
chrX_+_152760452 23.738 BGN
biglycan
chr8_-_22550456 21.966 EGR3
early growth response 3
chr8_-_22550057 20.436 NM_001199881
EGR3
early growth response 3
chr12_-_45270157 19.518 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr17_+_60705051 19.502 MRC2
mannose receptor, C type 2
chr15_+_48010685 19.349 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr19_-_51504799 18.761 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr17_+_60705042 18.686 MRC2
mannose receptor, C type 2
chr19_-_51523272 17.271 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr17_+_60704747 16.299 NM_006039
MRC2
mannose receptor, C type 2
chr12_-_45270632 16.004 NM_001145107
NELL2
NEL-like 2 (chicken)
chr18_-_45935627 15.953 ZBTB7C
zinc finger and BTB domain containing 7C
chr19_-_51522953 14.660 NM_145888
KLK10
kallikrein-related peptidase 10
chr5_+_137801166 14.146 EGR1
early growth response 1
chr19_-_51472003 13.427 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr1_+_164528914 13.022 PBX1
pre-B-cell leukemia homeobox 1
chr8_-_22550708 12.399 NM_004430
EGR3
early growth response 3
chr1_+_164528586 12.171 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr12_-_45269953 12.116 NELL2
NEL-like 2 (chicken)
chr11_+_130184326 11.580 FLJ34521
uncharacterized LOC646383
chr19_-_51472816 11.483 NM_002774
KLK6
kallikrein-related peptidase 6
chr10_+_5566923 11.315 NM_005185
CALML3
calmodulin-like 3
chr1_+_167599503 10.946 RCSD1
RCSD domain containing 1
chr7_+_29234325 10.783 CHN2
chimerin (chimaerin) 2
chr14_+_75745480 10.746 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_+_52445185 10.735 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr19_-_51512803 10.639 NM_012315
KLK9
kallikrein-related peptidase 9
chr4_-_105416050 10.552 CXXC4
CXXC finger protein 4
chr18_+_10454620 10.210 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr16_-_79634610 10.015 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr17_-_48072566 9.993 NM_005220
DLX3
distal-less homeobox 3
chr5_-_111093030 9.924 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr19_-_51071279 9.898 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr20_+_51589752 9.893 TSHZ2
teashirt zinc finger homeobox 2
chr4_+_7194317 9.751 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chrX_-_17879355 9.681 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr5_+_137801178 9.660 NM_001964
EGR1
early growth response 1
chr12_+_4382882 9.560 NM_001759
CCND2
cyclin D2
chr7_+_96635289 9.544 NM_005222
DLX6
distal-less homeobox 6
chr11_-_46142955 9.401 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr5_-_111092865 9.401 C5orf13
chromosome 5 open reading frame 13
chr15_+_48009510 9.219 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr10_-_44144266 9.075 NM_006973
ZNF32
zinc finger protein 32
chr5_-_111092918 9.050 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr7_+_69064316 8.933 AUTS2
autism susceptibility candidate 2
chr15_-_27018216 8.849 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_+_212781969 8.620 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr16_-_30934437 8.578 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chrX_+_102632108 8.313 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr3_+_184097860 8.208 NM_003741
CHRD
chordin
chrX_+_144899330 8.158 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr4_+_106816627 8.141 NPNT
nephronectin
chr1_+_212782103 8.108 ATF3
activating transcription factor 3
chr1_-_41950296 8.088 NM_001956
EDN2
endothelin 2
chr1_+_167599329 8.066 NM_052862
RCSD1
RCSD domain containing 1
chr1_-_40367539 8.055 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr14_+_24837225 7.952 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr20_-_9819406 7.874 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr7_+_73442486 7.862 ELN
elastin
chr17_-_27949814 7.825 CORO6
coronin 6
chr11_-_62688732 7.817 CHRM1
cholinergic receptor, muscarinic 1
chr19_-_36019194 7.815 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr14_-_91526912 7.762 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr10_-_98592186 7.748


chr10_-_64576074 7.664 EGR2
early growth response 2
chr16_-_31021716 7.641 NM_052874
STX1B
syntaxin 1B
chr11_-_64410785 7.640 NM_138734
NRXN2
neurexin 2
chr16_-_30042123 7.582 NM_031478
FAM57B
family with sequence similarity 57, member B
chr19_+_42788605 7.519 NM_015125
CIC
capicua homolog (Drosophila)
chr10_+_102505337 7.487 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr1_+_26737306 7.471 LIN28A
lin-28 homolog A (C. elegans)
chr12_-_45269340 7.465 NM_001145109
NELL2
NEL-like 2 (chicken)
chr3_-_161089747 7.462 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr15_-_82338348 7.438 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr7_+_29234111 7.406 NM_004067
CHN2
chimerin (chimaerin) 2
chr20_+_45523247 7.394 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr10_-_5541401 7.376 NM_017422
CALML5
calmodulin-like 5
chr7_-_142583260 7.343 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr5_-_132948222 7.258 NM_015082
FSTL4
follistatin-like 4
chr11_+_74951949 7.120 NM_001195528
LOC100507050
uncharacterized LOC100507050
chr14_-_91526731 7.040


chr16_+_55358470 6.999 NM_024335
IRX6
iroquois homeobox 6
chr13_-_36705432 6.996 DCLK1
doublecortin-like kinase 1
chrX_-_48693934 6.938 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr2_+_42275017 6.903 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr19_+_45971249 6.850 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr7_+_73442426 6.831 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr2_+_79740059 6.823 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr9_-_16870719 6.792 NM_017637
BNC2
basonuclin 2
chr6_-_152957985 6.744 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_73442451 6.715 ELN
elastin
chr7_+_1272552 6.703 NM_001080461
UNCX
UNC homeobox
chr15_-_82338459 6.698 MEX3B
mex-3 homolog B (C. elegans)
chr2_+_128175989 6.695 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr6_-_134497069 6.683 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr7_+_33945111 6.676 NM_133468
BMPER
BMP binding endothelial regulator
chr4_+_106816593 6.649 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr19_+_50016435 6.500 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_2159472 6.437 IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_-_30607762 6.405 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr20_-_55841090 6.397 BMP7
bone morphogenetic protein 7
chr1_+_160370363 6.364 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr14_-_54423448 6.243 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr2_+_217498082 6.242 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr19_+_15218141 6.241 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr10_-_44144151 6.234 NM_001005368
ZNF32
zinc finger protein 32
chr6_-_134496833 6.218 SGK1
serum/glucocorticoid regulated kinase 1
chr13_-_36705513 6.190 NM_004734
DCLK1
doublecortin-like kinase 1
chr18_-_22930826 6.144


chr17_-_33700619 6.133 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr5_+_172483285 6.117 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr20_+_45523523 6.104 EYA2
eyes absent homolog 2 (Drosophila)
chr2_+_48757292 6.061 NM_001198595
NM_006873
STON1

stonin 1

chr2_+_217498205 6.057 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr11_-_62689011 6.044 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr5_+_175298604 6.041 CPLX2
complexin 2
chr11_+_17757494 5.952 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr20_+_45523505 5.934 EYA2
eyes absent homolog 2 (Drosophila)
chr5_-_111093251 5.917 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr4_-_15003668 5.884 LOC441009
uncharacterized LOC441009
chr1_+_109656776 5.882 KIAA1324
KIAA1324
chr19_-_47975074 5.866 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr19_-_10047014 5.858 NM_058164
OLFM2
olfactomedin 2
chr1_+_203444882 5.830 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr17_+_40913233 5.822 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr18_+_10454625 5.813 APCDD1
adenomatosis polyposis coli down-regulated 1
chr21_+_40177847 5.802 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr10_-_88126201 5.765 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr19_+_51815095 5.721 NM_001101372
IGLON5
IgLON family member 5
chr18_+_10454542 5.688 APCDD1
adenomatosis polyposis coli down-regulated 1
chr11_-_27741192 5.688 NM_001143807
BDNF
brain-derived neurotrophic factor
chr9_+_35673852 5.654 NM_001216
CA9
carbonic anhydrase IX
chr5_-_134914447 5.615 CXCL14
chemokine (C-X-C motif) ligand 14
chr15_-_101084871 5.610 NM_178842
CERS3
ceramide synthase 3
chr1_+_109656724 5.601 KIAA1324
KIAA1324
chr19_+_55795533 5.577 NM_032430
BRSK1
BR serine/threonine kinase 1
chr11_-_2159784 5.572 IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_+_145567147 5.535 NM_022475
HHIP
hedgehog interacting protein
chr19_-_38916801 5.535 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr5_+_175298492 5.527 NM_001008220
CPLX2
complexin 2
chr21_+_40177754 5.504 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr16_+_56225250 5.487 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr14_+_24838301 5.448 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr6_-_152958533 5.447 NM_182961
SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_+_219724545 5.443 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr1_-_16539103 5.412 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr20_-_44937130 5.409 CDH22
cadherin 22, type 2
chr1_+_2985730 5.408 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr17_+_7741630 5.382


chr6_+_89790412 5.372 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr22_-_38966066 5.371 NM_007068
DMC1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
chr1_+_151009028 5.359 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chr8_-_93115453 5.346 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr1_-_214724974 5.330 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr22_+_41777932 5.306 NM_003216
TEF
thyrotrophic embryonic factor
chr7_+_73442468 5.304 ELN
elastin
chr19_+_41699140 5.297 CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr6_+_89790464 5.292 PNRC1
proline-rich nuclear receptor coactivator 1
chr17_+_6926366 5.276 NM_181844
BCL6B
B-cell CLL/lymphoma 6, member B
chr4_-_121993568 5.261 NM_024574
NDNF
neuron-derived neurotrophic factor
chr18_+_43405544 5.248 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr10_-_61122219 5.240 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr7_+_69063768 5.240 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr5_-_24645084 5.224 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr10_-_98945662 5.207 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr4_-_5889992 5.192 CRMP1
collapsin response mediator protein 1
chr1_+_226250413 5.166 H3F3A
H3 histone, family 3A
chr8_-_21988518 5.162 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr10_+_52834233 5.152 NM_006258
PRKG1
protein kinase, cGMP-dependent, type I
chr2_-_241759627 5.131 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr4_-_1107313 5.090 NM_001131034
NM_001193318
NM_194439
RNF212


ring finger protein 212


chr1_-_151345156 5.071 NM_003944
SELENBP1
selenium binding protein 1
chr16_-_10276610 5.063 NM_000833
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr3_+_53529030 5.057 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr1_-_68697997 5.055 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_+_110559647 5.041 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr5_-_36876730 5.010 LOC646719
uncharacterized LOC646719
chr2_+_128176019 4.995 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr3_-_114866090 4.975 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr19_-_51456159 4.963 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr17_-_40913028 4.943 LOC100190938
uncharacterized LOC100190938
chr6_+_21666645 4.935 LINC00340
long intergenic non-protein coding RNA 340
chr17_-_40913274 4.923 LOC100190938
uncharacterized LOC100190938
chr2_+_26915390 4.915 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr7_+_1126442 4.904 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr3_-_122746544 4.898 SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr1_+_109656570 4.896 NM_020775
KIAA1324
KIAA1324
chr14_+_24836144 4.886 NM_001136022
NM_001198967
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr13_-_36705466 4.857 DCLK1
doublecortin-like kinase 1
chr17_+_7155371 4.831 NM_203415
NM_015362
NM_203413
NM_203414
C17orf81



chromosome 17 open reading frame 81



chr17_-_16472463 4.830 NM_020653
ZNF287
zinc finger protein 287
chr11_-_64490654 4.819 NM_015080
NM_138732
NRXN2

neurexin 2

chr11_+_111169965 4.813 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr8_-_144241918 4.811 NM_001130478
LY6H
lymphocyte antigen 6 complex, locus H
chr8_-_143851223 4.804 NM_177458
LYNX1
Ly6/neurotoxin 1
chr11_+_125034558 4.804 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.67 4.56e-37 GO:0007275 multicellular organismal development
1.61 5.31e-35 GO:0032502 developmental process
1.70 5.87e-32 GO:0048731 system development
1.64 5.20e-30 GO:0048856 anatomical structure development
1.96 6.01e-27 GO:0007399 nervous system development
1.41 6.20e-25 GO:0032501 multicellular organismal process
1.73 1.86e-20 GO:0048513 organ development
1.68 6.95e-20 GO:0030154 cell differentiation
1.81 2.41e-19 GO:0009653 anatomical structure morphogenesis
1.66 5.13e-19 GO:0048869 cellular developmental process
1.25 2.21e-18 GO:0065007 biological regulation
1.28 7.27e-18 GO:0050794 regulation of cellular process
1.26 1.19e-17 GO:0050789 regulation of biological process
1.62 1.23e-17 GO:0006355 regulation of transcription, DNA-dependent
1.53 4.28e-17 GO:0009889 regulation of biosynthetic process
1.60 4.60e-17 GO:0051252 regulation of RNA metabolic process
1.54 5.91e-17 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.54 5.91e-17 GO:0031326 regulation of cellular biosynthetic process
2.00 2.26e-16 GO:0022008 neurogenesis
2.38 4.47e-16 GO:0007417 central nervous system development
1.54 1.38e-15 GO:0010556 regulation of macromolecule biosynthetic process
1.55 1.87e-15 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.50 2.39e-15 GO:0051171 regulation of nitrogen compound metabolic process
1.52 6.35e-15 GO:0010468 regulation of gene expression
1.98 6.73e-15 GO:0048699 generation of neurons
1.77 1.18e-14 GO:0051239 regulation of multicellular organismal process
1.94 1.67e-14 GO:0050793 regulation of developmental process
2.09 2.74e-14 GO:0030182 neuron differentiation
2.18 3.97e-14 GO:0009887 organ morphogenesis
1.87 1.55e-13 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.98 9.11e-13 GO:0007267 cell-cell signaling
2.04 1.11e-12 GO:0010628 positive regulation of gene expression
2.47 1.44e-12 GO:0007420 brain development
1.97 1.79e-12 GO:2000026 regulation of multicellular organismal development
2.03 1.92e-12 GO:0045595 regulation of cell differentiation
2.19 1.26e-11 GO:0019226 transmission of nerve impulse
2.19 1.26e-11 GO:0035637 multicellular organismal signaling
1.83 2.36e-11 GO:0048468 cell development
1.78 4.19e-11 GO:0007154 cell communication
1.36 4.43e-11 GO:0023052 signaling
1.37 4.80e-11 GO:0031323 regulation of cellular metabolic process
1.36 1.04e-10 GO:0080090 regulation of primary metabolic process
2.21 2.60e-10 GO:0007268 synaptic transmission
2.69 3.05e-10 GO:0048568 embryonic organ development
1.81 3.06e-10 GO:0006811 ion transport
1.98 4.31e-10 GO:0045893 positive regulation of transcription, DNA-dependent
2.13 7.79e-10 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.81 7.83e-10 GO:0009888 tissue development
1.32 1.72e-09 GO:0019222 regulation of metabolic process
1.89 3.23e-09 GO:0009790 embryo development
1.35 4.56e-09 GO:0060255 regulation of macromolecule metabolic process
1.84 6.48e-09 GO:0010557 positive regulation of macromolecule biosynthetic process
2.05 7.40e-09 GO:0000904 cell morphogenesis involved in differentiation
2.28 7.93e-09 GO:0007389 pattern specification process
2.31 1.12e-08 GO:0051093 negative regulation of developmental process
1.95 1.90e-08 GO:0048666 neuron development
2.90 2.57e-08 GO:0006813 potassium ion transport
2.97 2.79e-08 GO:0045165 cell fate commitment
1.86 2.82e-08 GO:0051254 positive regulation of RNA metabolic process
2.02 3.51e-08 GO:0030001 metal ion transport
2.78 4.80e-08 GO:0030900 forebrain development
1.88 5.47e-08 GO:0032989 cellular component morphogenesis
2.41 6.89e-08 GO:0045596 negative regulation of cell differentiation
2.49 7.01e-08 GO:0003002 regionalization
1.89 9.56e-08 GO:0000902 cell morphogenesis
1.78 1.03e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.82 1.42e-07 GO:0048565 digestive tract development
2.27 1.49e-07 GO:0022603 regulation of anatomical structure morphogenesis
1.71 2.02e-07 GO:0006351 transcription, DNA-dependent
1.72 2.38e-07 GO:0031328 positive regulation of cellular biosynthetic process
2.26 3.52e-07 GO:0048729 tissue morphogenesis
1.70 4.14e-07 GO:0009891 positive regulation of biosynthetic process
1.62 5.82e-07 GO:0010646 regulation of cell communication
2.76 6.36e-07 GO:0048562 embryonic organ morphogenesis
1.94 6.62e-07 GO:0031175 neuron projection development
3.51 8.22e-07 GO:0055123 digestive system development
1.73 8.33e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
2.00 9.25e-07 GO:0032583 regulation of gene-specific transcription
1.98 1.12e-06 GO:0048812 neuron projection morphogenesis
1.84 1.62e-06 GO:0006812 cation transport
2.17 1.72e-06 GO:0060284 regulation of cell development
2.16 2.00e-06 GO:0001501 skeletal system development
1.97 2.46e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.37 3.02e-06 GO:0048522 positive regulation of cellular process
2.21 4.46e-06 GO:0007423 sensory organ development
1.97 5.12e-06 GO:0007409 axonogenesis
1.87 6.20e-06 GO:0032990 cell part morphogenesis
2.09 6.31e-06 GO:0044057 regulation of system process
2.03 6.32e-06 GO:0048598 embryonic morphogenesis
1.34 7.00e-06 GO:0048518 positive regulation of biological process
1.87 8.52e-06 GO:0048858 cell projection morphogenesis
1.92 8.58e-06 GO:0051094 positive regulation of developmental process
1.42 1.29e-05 GO:0007166 cell surface receptor linked signaling pathway
2.17 1.66e-05 GO:0051960 regulation of nervous system development
1.80 3.02e-05 GO:0051253 negative regulation of RNA metabolic process
1.72 4.41e-05 GO:0030030 cell projection organization
1.80 4.53e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.93 5.28e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
3.98 6.33e-05 GO:0021510 spinal cord development
1.34 8.72e-05 GO:0048519 negative regulation of biological process
1.95 9.95e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.67 1.01e-04 GO:0009890 negative regulation of biosynthetic process
4.42 1.11e-04 GO:0048546 digestive tract morphogenesis
2.00 1.25e-04 GO:0015672 monovalent inorganic cation transport
1.55 1.38e-04 GO:0032774 RNA biosynthetic process
1.71 1.43e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.26 1.46e-04 GO:0007165 signal transduction
1.35 1.50e-04 GO:0048523 negative regulation of cellular process
1.98 1.85e-04 GO:0045597 positive regulation of cell differentiation
2.75 2.14e-04 GO:0043583 ear development
2.27 2.48e-04 GO:0045664 regulation of neuron differentiation
1.69 2.79e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.62 2.83e-04 GO:0007155 cell adhesion
1.62 2.83e-04 GO:0022610 biological adhesion
1.67 3.05e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
2.91 3.61e-04 GO:0021537 telencephalon development
1.89 3.77e-04 GO:0060429 epithelium development
2.12 3.97e-04 GO:0050767 regulation of neurogenesis
1.64 4.03e-04 GO:0031327 negative regulation of cellular biosynthetic process
2.47 4.30e-04 GO:0001655 urogenital system development
2.88 4.69e-04 GO:0048839 inner ear development
1.48 4.90e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.68 4.96e-04 GO:0010629 negative regulation of gene expression
2.55 6.51e-04 GO:0048705 skeletal system morphogenesis
2.02 6.52e-04 GO:0035295 tube development
1.66 7.43e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.95 9.48e-04 GO:0007610 behavior
1.51 9.93e-04 GO:0042127 regulation of cell proliferation
1.54 1.07e-03 GO:0040011 locomotion
2.22 1.14e-03 GO:0048732 gland development
2.59 1.46e-03 GO:0050804 regulation of synaptic transmission
2.10 1.54e-03 GO:0002009 morphogenesis of an epithelium
1.71 1.61e-03 GO:0008284 positive regulation of cell proliferation
2.49 1.69e-03 GO:0051969 regulation of transmission of nerve impulse
1.85 1.72e-03 GO:0043009 chordate embryonic development
1.43 1.93e-03 GO:0009893 positive regulation of metabolic process
2.31 1.96e-03 GO:0009952 anterior/posterior pattern formation
2.39 2.24e-03 GO:0031644 regulation of neurological system process
1.82 2.66e-03 GO:0009792 embryo development ending in birth or egg hatching
1.49 2.70e-03 GO:0032879 regulation of localization
6.48 2.77e-03 GO:0048745 smooth muscle tissue development
2.72 2.83e-03 GO:0030324 lung development
1.37 2.84e-03 GO:0023051 regulation of signaling
3.07 2.90e-03 GO:0010001 glial cell differentiation
4.88 3.05e-03 GO:0050807 regulation of synapse organization
3.62 3.82e-03 GO:0048663 neuron fate commitment
1.71 5.45e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.68 5.58e-03 GO:0009967 positive regulation of signal transduction
2.63 5.62e-03 GO:0030323 respiratory tube development
1.66 5.77e-03 GO:0010647 positive regulation of cell communication
3.65 6.72e-03 GO:0007613 memory
1.65 7.47e-03 GO:0023056 positive regulation of signaling
3.18 9.13e-03 GO:0021543 pallium development
4.49 9.54e-03 GO:0048566 embryonic digestive tract development
2.62 9.81e-03 GO:0006816 calcium ion transport
2.62 9.81e-03 GO:0007626 locomotory behavior
2.80 1.05e-02 GO:0021953 central nervous system neuron differentiation
1.67 1.35e-02 GO:0072358 cardiovascular system development
1.67 1.35e-02 GO:0072359 circulatory system development
4.06 1.54e-02 GO:0001709 cell fate determination
3.60 1.73e-02 GO:0021987 cerebral cortex development
1.40 1.81e-02 GO:0031325 positive regulation of cellular metabolic process
2.09 2.07e-02 GO:0030855 epithelial cell differentiation
2.00 2.17e-02 GO:0043193 positive regulation of gene-specific transcription
4.16 2.60e-02 GO:0050803 regulation of synapse structure and activity
1.19 2.71e-02 GO:0051716 cellular response to stimulus
3.64 3.06e-02 GO:0021536 diencephalon development
2.27 3.11e-02 GO:0070838 divalent metal ion transport
2.77 3.29e-02 GO:2000027 regulation of organ morphogenesis
2.36 3.65e-02 GO:0060541 respiratory system development
2.28 3.70e-02 GO:0030799 regulation of cyclic nucleotide metabolic process
2.68 3.78e-02 GO:0042471 ear morphogenesis
3.12 3.95e-02 GO:0032412 regulation of ion transmembrane transporter activity
3.12 3.95e-02 GO:0060348 bone development
1.91 4.19e-02 GO:0040007 growth

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.53 1.69e-14 GO:0044459 plasma membrane part
1.71 2.91e-13 GO:0031226 intrinsic to plasma membrane
1.69 2.18e-12 GO:0005887 integral to plasma membrane
2.84 2.79e-12 GO:0034702 ion channel complex
3.12 4.96e-10 GO:0034703 cation channel complex
1.30 7.31e-10 GO:0005886 plasma membrane
2.12 1.99e-09 GO:0045202 synapse
1.28 4.35e-09 GO:0071944 cell periphery
2.21 8.63e-08 GO:0044456 synapse part
1.21 2.33e-07 GO:0031224 intrinsic to membrane
5.17 2.01e-06 GO:0034704 calcium channel complex
1.97 2.05e-06 GO:0031012 extracellular matrix
1.17 5.66e-06 GO:0044425 membrane part
1.91 6.04e-06 GO:0043005 neuron projection
2.02 7.81e-06 GO:0005578 proteinaceous extracellular matrix
5.80 8.55e-06 GO:0005891 voltage-gated calcium channel complex
1.19 1.83e-05 GO:0016021 integral to membrane
1.14 1.04e-04 GO:0016020 membrane
3.80 1.03e-03 GO:0042734 presynaptic membrane
2.69 1.13e-03 GO:0008076 voltage-gated potassium channel complex
2.69 1.13e-03 GO:0034705 potassium channel complex
2.21 1.96e-03 GO:0045211 postsynaptic membrane
1.57 2.40e-03 GO:0030054 cell junction
2.09 3.25e-03 GO:0043025 neuronal cell body
1.41 3.88e-03 GO:0044421 extracellular region part
1.28 5.21e-03 GO:0005576 extracellular region
2.03 6.58e-03 GO:0044297 cell body
1.99 6.62e-03 GO:0030425 dendrite
2.21 9.33e-03 GO:0031225 anchored to membrane
1.67 1.06e-02 GO:0009986 cell surface
2.46 4.32e-02 GO:0033267 axon part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.55 4.03e-30 GO:0043565 sequence-specific DNA binding
2.23 3.03e-29 GO:0001071 nucleic acid binding transcription factor activity
2.23 3.03e-29 GO:0003700 sequence-specific DNA binding transcription factor activity
1.93 1.52e-17 GO:0030528 transcription regulator activity
2.51 3.94e-16 GO:0005216 ion channel activity
2.47 1.31e-15 GO:0022838 substrate-specific channel activity
2.80 3.72e-15 GO:0005261 cation channel activity
2.42 4.38e-15 GO:0015267 channel activity
2.41 5.30e-15 GO:0022803 passive transmembrane transporter activity
2.61 3.63e-14 GO:0022836 gated channel activity
3.30 3.95e-12 GO:0022843 voltage-gated cation channel activity
2.85 6.73e-11 GO:0005244 voltage-gated ion channel activity
2.85 6.73e-11 GO:0022832 voltage-gated channel activity
1.86 1.36e-10 GO:0015075 ion transmembrane transporter activity
1.99 2.28e-10 GO:0008324 cation transmembrane transporter activity
1.44 2.31e-10 GO:0003677 DNA binding
1.68 7.09e-08 GO:0022891 substrate-specific transmembrane transporter activity
2.97 8.11e-08 GO:0005267 potassium channel activity
1.60 1.47e-06 GO:0022857 transmembrane transporter activity
2.41 1.59e-06 GO:0010843 promoter binding
2.36 2.37e-06 GO:0000975 regulatory region DNA binding
2.36 2.37e-06 GO:0001067 regulatory region nucleic acid binding
2.36 2.37e-06 GO:0044212 transcription regulatory region DNA binding
3.28 7.62e-06 GO:0005262 calcium channel activity
2.96 1.08e-05 GO:0005249 voltage-gated potassium channel activity
2.01 1.72e-05 GO:0016563 transcription activator activity
1.48 2.90e-05 GO:0005215 transporter activity
1.52 2.90e-05 GO:0022892 substrate-specific transporter activity
4.68 4.38e-04 GO:0005245 voltage-gated calcium channel activity
1.28 5.78e-03 GO:0004871 signal transducer activity
1.28 5.78e-03 GO:0060089 molecular transducer activity
2.52 7.02e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
2.25 1.13e-02 GO:0015276 ligand-gated ion channel activity
2.25 1.13e-02 GO:0022834 ligand-gated channel activity
2.57 1.59e-02 GO:0005201 extracellular matrix structural constituent
2.10 1.92e-02 GO:0046873 metal ion transmembrane transporter activity
4.26 2.57e-02 GO:0015079 potassium ion transmembrane transporter activity
1.19 3.24e-02 GO:0003676 nucleic acid binding
2.09 3.79e-02 GO:0005516 calmodulin binding