Motif ID: GTF2A1,2.p2

Z-value: 1.515


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2A1hg19_v1_chr14_-_81687574_81687574-0.412.8e-04Click!
GTF2A2hg19_v1_chr15_-_59949536_59949765-0.325.0e-03Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_74495093 14.151 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr10_+_101542460 12.254 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr15_+_74495341 11.540


chr15_-_74495399 11.538 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr15_-_74495528 10.511 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr10_+_101542554 9.789 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr19_+_6772705 9.589 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chrX_-_110513665 8.842 CAPN6
calpain 6
chr9_+_92219926 7.087 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr6_-_24877453 6.399 NM_015864
FAM65B
family with sequence similarity 65, member B
chr19_+_49468587 6.300 FTL
ferritin, light polypeptide
chr14_-_73360792 6.250 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr19_+_49468656 6.077 FTL
ferritin, light polypeptide
chr19_+_49468557 5.999 NM_000146
FTL
ferritin, light polypeptide
chr1_+_201979747 5.590 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr2_+_11682836 5.418 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr2_+_11682787 5.307 GREB1
growth regulation by estrogen in breast cancer 1
chr22_+_22676814 5.048


chr3_-_62359189 4.870 NM_018008
FEZF2
FEZ family zinc finger 2
chrX_-_15402469 4.828 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr4_+_6695565 4.594 NM_005980
S100P
S100 calcium binding protein P
chr19_+_6772801 4.533


chr22_-_30685485 4.445 NM_001037666
GATSL3
GATS protein-like 3
chr19_-_45909566 4.399 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr11_-_2018568 4.395 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018446 4.094 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_-_2018334 4.009 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr15_-_65067696 3.894 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr22_-_22089975 3.891 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr15_-_74494780 3.779 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr4_-_122148620 3.720 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr10_-_49482912 3.554 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr19_+_49622480 3.516 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr12_-_371994 3.496 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chr14_+_75745480 3.496 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr22_-_39268169 3.452 CBX6
chromobox homolog 6
chr5_-_145483877 3.427 NM_001029869
PLAC8L1
PLAC8-like 1
chr17_-_39203423 3.416 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr17_-_39092714 3.410 KRT23
keratin 23 (histone deacetylase inducible)
chr22_+_35777087 3.385 HMOX1
heme oxygenase (decycling) 1
chr22_+_35777051 3.328 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr6_-_24583454 3.312 NM_001252328
KIAA0319
KIAA0319
chr3_+_194406614 3.266 NM_153690
FAM43A
family with sequence similarity 43, member A
chr4_-_23891608 3.222 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_+_13263890 3.206 IER2
immediate early response 2
chr19_+_54606141 3.169 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr5_+_60933635 3.140 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr6_+_26104103 3.070 NM_003542
HIST2H4B
HIST1H4C
histone cluster 2, H4b
histone cluster 1, H4c
chr19_+_56153417 3.049 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr19_-_49140569 3.036 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr5_-_76382905 3.012 NM_032367
ZBED3
zinc finger, BED-type containing 3
chr4_+_41614911 3.011 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr11_+_64107687 2.943 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr22_-_39268214 2.930 CBX6
chromobox homolog 6
chr16_+_83986826 2.918 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr15_-_74494851 2.909 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr4_+_41614933 2.894 LIMCH1
LIM and calponin homology domains 1
chr11_-_2019070 2.880 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr3_+_185080835 2.826 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr15_-_83378488 2.820 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr22_-_39268230 2.818 NM_014292
CBX6
chromobox homolog 6
chr20_+_43803539 2.774 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr10_+_17794250 2.734 NM_001098844
TMEM236
transmembrane protein 236
chr2_-_27531113 2.723 NM_003353
UCN
urocortin
chr4_+_41614725 2.697 LIMCH1
LIM and calponin homology domains 1
chr17_-_48278874 2.672 COL1A1
collagen, type I, alpha 1
chr17_-_48278987 2.664 NM_000088
COL1A1
collagen, type I, alpha 1
chr1_+_111770280 2.605 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr15_-_76005095 2.603 CSPG4
chondroitin sulfate proteoglycan 4
chr2_+_28616346 2.584 FOSL2
FOS-like antigen 2
chr2_+_28616360 2.579 FOSL2
FOS-like antigen 2
chr4_-_57547845 2.553 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr22_-_38479148 2.546 NM_013356
SLC16A8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
chr19_+_45909868 2.517 CD3EAP
CD3e molecule, epsilon associated protein
chr2_+_28615695 2.516 FOSL2
FOS-like antigen 2
chr19_+_40697516 2.510 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr17_-_73840587 2.444 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr20_-_749127 2.422 NM_033409
C20orf54
chromosome 20 open reading frame 54
chr19_-_49176263 2.417 NM_145807
NTN5
netrin 5
chr1_+_47264669 2.411 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr2_-_239148545 2.350 HES6
hairy and enhancer of split 6 (Drosophila)
chr11_-_1593149 2.323 NM_004420
DUSP8
dual specificity phosphatase 8
chr19_-_54692132 2.312 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr9_-_131644176 2.309 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr19_-_54974893 2.295 NM_198988
LENG9
leukocyte receptor cluster (LRC) member 9
chr9_+_131580719 2.290 NM_004435
ENDOG
endonuclease G
chr4_-_149363304 2.274 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr22_-_24640850 2.268 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr6_-_41130820 2.241 TREM2
triggering receptor expressed on myeloid cells 2
chr19_+_45458598 2.235 NM_001294
CLPTM1
cleft lip and palate associated transmembrane protein 1
chr2_+_28615771 2.232 NM_005253
FOSL2
FOS-like antigen 2
chr2_+_169937616 2.230 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_+_49128208 2.223 NM_001204160
SPHK2
sphingosine kinase 2
chr19_+_45458646 2.201 CLPTM1
cleft lip and palate associated transmembrane protein 1
chr19_-_46389307 2.174 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr19_-_50083791 2.170 NM_015953
NOSIP
nitric oxide synthase interacting protein
chr19_+_1040114 2.153 ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr6_-_41130864 2.141 TREM2
triggering receptor expressed on myeloid cells 2
chr19_+_2222415 2.127 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr13_+_43136871 2.119 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chrX_+_9431314 2.117 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr17_+_18281078 2.096 NM_001145127
EVPLL
envoplakin-like
chr19_+_13906207 2.088 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr6_-_32151996 2.061 NM_001136
NM_001206929
NM_001206932
NM_001206934
NM_001206936
NM_001206940
NM_001206954
NM_001206966
NM_172197
AGER








advanced glycosylation end product-specific receptor








chr6_-_41130921 2.023 NM_018965
TREM2
triggering receptor expressed on myeloid cells 2
chr2_-_24149899 2.013 NM_001242338
NM_017552
ATAD2B

ATPase family, AAA domain containing 2B

chr17_+_45286713 1.992 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr17_+_80193649 1.956 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr7_-_7575449 1.956 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr2_+_119699744 1.943 NM_006770
MARCO
macrophage receptor with collagenous structure
chr17_+_54230835 1.929 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr17_-_19651586 1.923 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr4_-_149363498 1.912 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr15_+_59908908 1.899 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr14_-_64761077 1.890 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr16_+_691901 1.883 FAM195A
family with sequence similarity 195, member A
chr1_-_153283166 1.882 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr2_-_50574891 1.867 NM_138735
NRXN1
neurexin 1
chrX_+_150345055 1.863 NM_004224
GPR50
G protein-coupled receptor 50
chr6_+_27114860 1.860 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr19_+_859658 1.853 NM_001928
CFD
complement factor D (adipsin)
chr19_+_1040079 1.819 NM_019112
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr11_-_73720281 1.816 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr19_+_45909466 1.813 NM_012099
CD3EAP
CD3e molecule, epsilon associated protein
chr19_+_2476122 1.805 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr2_+_242498118 1.801 NM_032515
BOK
BCL2-related ovarian killer
chr6_+_43139201 1.800 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr12_+_113495661 1.796 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr9_+_35538890 1.795 RUSC2
RUN and SH3 domain containing 2
chr2_-_202222066 1.773 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr1_-_20306908 1.765 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr19_-_50083813 1.761 NOSIP
nitric oxide synthase interacting protein
chr15_+_67000929 1.755 NM_001142861
SMAD6
SMAD family member 6
chr11_+_65657874 1.753 NM_006848
CCDC85B
coiled-coil domain containing 85B
chr7_+_55980330 1.748 NM_182633
ZNF713
zinc finger protein 713
chr19_+_859673 1.744 CFD
complement factor D (adipsin)
chr19_-_44031310 1.740 NM_014297
ETHE1
ethylmalonic encephalopathy 1
chr19_+_42388445 1.735 NM_199002
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr2_-_175712276 1.715 NM_001206602
CHN1
chimerin (chimaerin) 1
chr17_+_18625335 1.715 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr12_-_52995215 1.708 NM_001146225
NM_001146226
NM_080747
KRT72


keratin 72


chr1_-_27339448 1.694 FAM46B
family with sequence similarity 46, member B
chr2_-_239148626 1.692 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr11_+_36317724 1.684 NM_001160167
PRR5L
proline rich 5 like
chr9_+_35538628 1.683 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr2_-_134326030 1.681 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr19_+_39833132 1.679 SAMD4B
sterile alpha motif domain containing 4B
chr19_+_39109848 1.678 EIF3K
eukaryotic translation initiation factor 3, subunit K
chr11_+_117049387 1.666 SIDT2
SID1 transmembrane family, member 2
chr10_+_18041217 1.660 NM_001098844
TMEM236
transmembrane protein 236
chr16_+_691827 1.659 NM_138418
FAM195A
family with sequence similarity 195, member A
chr15_+_91643181 1.649 NM_001167580
SV2B
synaptic vesicle glycoprotein 2B
chr22_-_41032684 1.646 NM_020831
MKL1
megakaryoblastic leukemia (translocation) 1
chr5_+_67586466 1.641 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_76382458 1.638 LOC728723
uncharacterized LOC728723
chr15_-_76005179 1.634 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr1_+_22138757 1.621 NM_001013693
LDLRAD2
low density lipoprotein receptor class A domain containing 2
chr4_-_82126200 1.610 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr19_+_39833096 1.608 SAMD4B
sterile alpha motif domain containing 4B
chr16_-_74455239 1.607 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr10_+_74653338 1.602 NM_152635
OIT3
oncoprotein induced transcript 3
chr16_-_787888 1.596 NARFL
nuclear prelamin A recognition factor-like
chr6_+_43139190 1.595 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_+_202125222 1.570 NM_033356
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr7_-_99277518 1.568 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr17_-_41985112 1.558 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr19_+_39833099 1.552 NM_018028
SAMD4B
sterile alpha motif domain containing 4B
chr10_-_103599596 1.544 NM_173194
KCNIP2
Kv channel interacting protein 2
chr19_-_39402797 1.540 NM_001243212
LOC643669
uncharacterized LOC643669
chr5_-_134369841 1.538 NM_002653
PITX1
paired-like homeodomain 1
chr6_-_31865439 1.515 EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr12_+_86268072 1.513 NM_006183
NTS
neurotensin
chr15_+_66995414 1.513 SMAD6
SMAD family member 6
chr1_-_57045214 1.502 PPAP2B
phosphatidic acid phosphatase type 2B
chr19_-_1479176 1.502 C19orf25
chromosome 19 open reading frame 25
chr6_-_45983279 1.488 NM_016929
CLIC5
chloride intracellular channel 5
chr19_+_17666381 1.487 GLT25D1
glycosyltransferase 25 domain containing 1
chr1_-_207119707 1.472 NM_002644
PIGR
polymeric immunoglobulin receptor
chr22_-_41032623 1.470 MKL1
megakaryoblastic leukemia (translocation) 1
chr9_+_116263706 1.453 NM_130795
RGS3
regulator of G-protein signaling 3
chr2_+_12858363 1.440


chr19_-_41255827 1.439 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr6_+_43138919 1.435 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr1_-_153067000 1.425 NM_001024209
SPRR2E
small proline-rich protein 2E
chr17_-_66951381 1.424 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr1_-_16482426 1.423 NM_004431
EPHA2
EPH receptor A2
chr19_+_41082792 1.423 SHKBP1
SH3KBP1 binding protein 1
chr1_+_86046434 1.415 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr12_-_125052009 1.413 NM_001077261
NM_001206654
NM_006312
NCOR2


nuclear receptor corepressor 2


chr19_-_49014832 1.410


chr4_+_115519557 1.406 NM_001128174
UGT8
UDP glycosyltransferase 8
chr19_+_10222196 1.404 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr17_+_73629513 1.399 NM_001162995
C17orf109
chromosome 17 open reading frame 109
chr1_+_995072 1.393 LOC100288175
uncharacterized LOC100288175
chr1_-_232651227 1.390 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr19_+_46010711 1.389 VASP
vasodilator-stimulated phosphoprotein
chr10_-_5045967 1.382 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr19_+_41082729 1.364 NM_138392
SHKBP1
SH3KBP1 binding protein 1
chr1_-_27339326 1.360 NM_052943
FAM46B
family with sequence similarity 46, member B
chr1_-_153044083 1.359 NM_001017418
SPRR2B
small proline-rich protein 2B

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
14.97 1.97e-02 GO:0001533 cornified envelope

Nothing significant found in function category.