Motif ID: GATA1..3.p2

Z-value: 2.305


Transcription factors associated with GATA1..3.p2:

Gene SymbolEntrez IDGene Name
GATA1 2623 GATA binding protein 1 (globin transcription factor 1)
GATA2 2624 GATA binding protein 2
GATA3 2625 GATA binding protein 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA3hg19_v1_chr10_+_8096633_80966660.481.3e-05Click!
GATA1hg19_v1_chrX_+_48644961_486450150.412.1e-04Click!
GATA2hg19_v1_chr3_-_128206704_128206775-0.217.6e-02Click!


Activity profile for motif GATA1..3.p2.

activity profile for motif GATA1..3.p2


Sorted Z-values histogram for motif GATA1..3.p2

Sorted Z-values for motif GATA1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_164528914 26.198 PBX1
pre-B-cell leukemia homeobox 1
chr1_+_212788359 26.121 NM_001206486
ATF3
activating transcription factor 3
chr8_-_22550456 20.093 EGR3
early growth response 3
chr15_+_48010685 19.526 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr8_-_22550057 19.351 NM_001199881
EGR3
early growth response 3
chr8_-_124665165 15.201 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr1_+_212738675 13.200 NM_001030287
ATF3
activating transcription factor 3
chr17_+_42634598 13.054 NM_001466
FZD2
frizzled family receptor 2
chr1_-_116383692 12.416 NM_005599
NHLH2
nescient helix loop helix 2
chr9_-_73028278 11.852 KLF9
Kruppel-like factor 9
chr8_-_22550708 11.727 NM_004430
EGR3
early growth response 3
chr3_-_48700317 10.775 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr17_+_67410825 10.769 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr11_-_8285299 10.677 NM_002315
LMO1
LIM domain only 1 (rhombotin 1)
chr8_-_22549901 10.656 NM_001199880
EGR3
early growth response 3
chr11_-_85469043 10.382 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr17_+_26850958 10.376 NM_003593
FOXN1
forkhead box N1
chr9_-_35618300 9.688 NM_001782
CD72
CD72 molecule
chr4_-_186733372 9.574 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_-_16424391 9.547 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr4_-_186877869 9.222 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr13_+_43148182 9.203 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_-_116383323 8.933 NM_001111061
NHLH2
nescient helix loop helix 2
chr4_-_186877413 8.635 SORBS2
sorbin and SH3 domain containing 2
chr2_-_145274916 8.602 ZEB2
zinc finger E-box binding homeobox 2
chr3_-_108672547 8.541 NM_005459
GUCA1C
guanylate cyclase activator 1C
chrX_-_154563735 8.491 NM_001289
CLIC2
chloride intracellular channel 2
chr12_-_122240827 8.336


chr5_+_145317297 8.266 SH3RF2
SH3 domain containing ring finger 2
chr2_-_96781887 8.244 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr4_-_186732047 8.105 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr17_-_27948345 7.941 NM_032854
CORO6
coronin 6
chr14_-_80677839 7.852 NM_001007023
NM_001242502
NM_001242503
NM_013989
DIO2



deiodinase, iodothyronine, type II



chr4_-_68995586 7.813 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr11_-_27742224 7.770 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr5_-_24645084 7.667 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr12_+_54447660 7.609 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr21_-_31588242 7.502 NM_199328
CLDN8
claudin 8
chr15_+_48009510 7.443 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr5_-_124080773 7.437 NM_020747
ZNF608
zinc finger protein 608
chr19_+_15160194 7.337 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr2_+_8822112 7.310 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr20_-_48099178 7.246 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr10_-_92681025 7.048 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr15_+_42651697 6.888 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr5_-_139944045 6.831 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr11_-_35547144 6.828 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr22_+_38201300 6.732 H1F0
H1 histone family, member 0
chr9_-_123688352 6.630 TRAF1
TNF receptor-associated factor 1
chr2_-_175869910 6.577 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr3_+_160473995 6.456 NM_139245
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr2_+_220436953 6.417 NM_002191
INHA
inhibin, alpha
chr12_+_51318743 6.416 METTL7A
methyltransferase like 7A
chr3_+_107096187 6.411 NM_032600
CCDC54
coiled-coil domain containing 54
chr9_+_77112251 6.273 NM_006914
RORB
RAR-related orphan receptor B
chr5_+_156820161 6.188 CYFIP2
cytoplasmic FMR1 interacting protein 2
chrX_+_49126326 6.044 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr11_-_47470687 5.759 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr19_-_50979461 5.755 FAM71E1
family with sequence similarity 71, member E1
chr6_-_33285493 5.665 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr1_-_108507474 5.647 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_34079896 5.647 NM_139285
GAS2L2
growth arrest-specific 2 like 2
chr14_-_107218786 5.532 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr5_-_95768660 5.445 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_-_182354649 5.422 GLUL
glutamate-ammonia ligase
chr10_+_104678001 5.383 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr6_+_26225382 5.381 NM_003532
HIST1H3E
histone cluster 1, H3e
chr1_+_92632608 5.370 NM_015237
KIAA1107
KIAA1107
chrX_+_105937067 5.346 NM_024539
RNF128
ring finger protein 128
chr15_-_40398286 5.293 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr1_+_51435641 5.290 NM_078626
CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr1_+_116380404 5.280 NHLH2
nescient helix loop helix 2
chr5_+_137801178 5.255 NM_001964
EGR1
early growth response 1
chr14_-_23652840 5.221 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr6_-_30043547 5.205 NM_170769
NM_025236
RNF39

ring finger protein 39

chr9_+_35829208 5.193 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr1_+_51435911 5.138 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_-_32095974 5.122 ATF6B
activating transcription factor 6 beta
chr2_+_169937616 5.117 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr2_-_145277879 5.101 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr5_+_42549657 5.087 NM_001242404
GHR
growth hormone receptor
chr8_-_108510094 5.068 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr11_+_7618416 5.036 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_-_92680784 5.019 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_171810611 5.016 NM_001136127
NM_015569
DNM3

dynamin 3

chr1_+_167599503 4.990 RCSD1
RCSD domain containing 1
chr6_-_32095993 4.975 NM_001136153
NM_004381
ATF6B

activating transcription factor 6 beta

chr7_-_143929935 4.928 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr11_-_102826433 4.893 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr4_-_186577858 4.887 SORBS2
sorbin and SH3 domain containing 2
chr3_-_121379701 4.883 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr4_-_77819001 4.860 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr12_+_57849086 4.845 NM_031479
INHBE
inhibin, beta E
chr4_-_159092509 4.833 FAM198B
family with sequence similarity 198, member B
chr12_-_54689536 4.804 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_+_27100784 4.802 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr5_-_139943829 4.794 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chrX_-_55020510 4.788 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr16_-_31214054 4.787 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chr19_-_7698569 4.783 NM_174895
PCP2
Purkinje cell protein 2
chr9_-_3525721 4.778 RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr9_+_35829375 4.768 NM_001042590
TMEM8B
transmembrane protein 8B
chr14_-_64749530 4.760 NM_001214902
NM_001214903
ESR2

estrogen receptor 2 (ER beta)

chr5_+_137801166 4.758 EGR1
early growth response 1
chr16_+_56225250 4.755 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr9_-_3525973 4.753 NM_002919
NM_134428
RFX3

regulatory factor X, 3 (influences HLA class II expression)

chr22_+_22676814 4.715


chr3_-_143567163 4.671 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr9_+_135037015 4.662 NTNG2
netrin G2
chr17_-_47841468 4.658 FAM117A
family with sequence similarity 117, member A
chr10_-_105212022 4.631 CALHM2
calcium homeostasis modulator 2
chr12_+_56732658 4.621 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr2_-_183731279 4.607 NM_001463
FRZB
frizzled-related protein
chrX_+_49126480 4.593 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr19_-_11545900 4.544 NM_145045
CCDC151
coiled-coil domain containing 151
chr18_+_34409058 4.538 NM_020776
KIAA1328
KIAA1328
chr4_-_13546037 4.509 NM_001189
NKX3-2
NK3 homeobox 2
chr2_-_145275086 4.495 ZEB2
zinc finger E-box binding homeobox 2
chr6_-_111136616 4.439 CDK19
cyclin-dependent kinase 19
chr2_+_169923531 4.436 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_-_41934634 4.433 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr17_+_28256873 4.396 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr10_-_123353330 4.390 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr17_-_56606534 4.385 SEPT4
septin 4
chrX_+_49126299 4.384 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr14_-_23652818 4.375 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr4_+_159091903 4.367 LOC285505
uncharacterized LOC285505
chr1_+_207039153 4.357 NM_018724
IL20
interleukin 20
chr2_-_190044330 4.324 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_-_49170490 4.318 NM_002292
LAMB2
laminin, beta 2 (laminin S)
chr2_+_74685526 4.302 NM_012477
WBP1
WW domain binding protein 1
chr6_-_48036385 4.266 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr17_+_72439187 4.240 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_+_233925104 4.234 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr11_+_113930296 4.215 ZBTB16
zinc finger and BTB domain containing 16
chr4_-_141074122 4.201 MAML3
mastermind-like 3 (Drosophila)
chr14_-_23623493 4.167 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr2_+_85980600 4.154 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr19_-_7701852 4.148


chr22_-_31688329 4.126 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr15_-_52404922 4.125 NM_020396
BCL2L10
BCL2-like 10 (apoptosis facilitator)
chr5_-_134914447 4.117 CXCL14
chemokine (C-X-C motif) ligand 14
chr15_-_40398573 4.113 NM_033503
BMF
Bcl2 modifying factor
chr19_+_16435632 4.094 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr2_+_56411123 4.090 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr3_-_49170427 4.088 LAMB2
laminin, beta 2 (laminin S)
chr9_+_3526047 4.073


chr1_+_26644380 4.047 NM_001803
CD52
CD52 molecule
chr5_+_53751430 4.031 NM_006308
HSPB3
heat shock 27kDa protein 3
chr1_+_154300275 4.023 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr5_-_160112266 4.019 ATP10B
ATPase, class V, type 10B
chr16_-_31214003 4.009 PYCARD
PYD and CARD domain containing
chr16_-_31161381 3.960 NM_173502
PRSS36
protease, serine, 36
chr4_-_186732208 3.952 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr14_+_21467413 3.944 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr22_-_38479148 3.937 NM_013356
SLC16A8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
chr14_+_62462540 3.931 NM_031914
SYT16
synaptotagmin XVI
chr17_-_56406120 3.931 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr6_-_26250832 3.928 NM_021018
HIST1H3J
HIST1H3F
histone cluster 1, H3j
histone cluster 1, H3f
chr10_-_123353771 3.912 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr20_-_43438881 3.909 NM_001205317
NM_182970
RIMS4

regulating synaptic membrane exocytosis 4

chr10_-_105212149 3.892 NM_015916
CALHM2
calcium homeostasis modulator 2
chr7_+_100136784 3.853 NM_006076
AGFG2
ArfGAP with FG repeats 2
chr17_+_4046941 3.849 CYB5D2
cytochrome b5 domain containing 2
chr17_-_74533623 3.833 NM_134268
CYGB
cytoglobin
chr6_-_32119717 3.823 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr11_-_111782447 3.823 NM_001885
CRYAB
crystallin, alpha B
chr6_-_32119667 3.816 PRRT1
proline-rich transmembrane protein 1
chr2_-_145277568 3.797 ZEB2
zinc finger E-box binding homeobox 2
chr6_+_42751155 3.783 FLJ38717
FLJ38717 protein
chr6_+_31543340 3.783 NM_000594
TNF
tumor necrosis factor
chr10_+_63661395 3.778 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_+_27528376 3.746 BDNF-AS1
BDNF antisense RNA 1 (non-protein coding)
chr19_-_17014407 3.734 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr12_+_51318515 3.730 NM_014033
METTL7A
methyltransferase like 7A
chr12_-_10282680 3.717 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr9_+_12775713 3.696 C9orf150
chromosome 9 open reading frame 150
chrX_+_53078505 3.684 NM_018969
GPR173
G protein-coupled receptor 173
chr3_-_187452669 3.680 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr6_-_43477980 3.678 LRRC73
leucine rich repeat containing 73
chr16_-_28303366 3.677


chr6_-_26199439 3.669 NM_021065
NM_003530
HIST1H2AD
HIST1H3D
histone cluster 1, H2ad
histone cluster 1, H3d
chr16_+_3405888 3.659 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr12_-_6772252 3.644 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr14_+_64682671 3.640 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr2_-_60780767 3.625 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr1_+_149824180 3.613 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr2_-_214016332 3.607 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr20_+_33299315 3.601 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr2_-_61245363 3.593 NM_144709
PUS10
pseudouridylate synthase 10
chr1_+_46972667 3.586 NM_147192
NM_172225
DMBX1

diencephalon/mesencephalon homeobox 1

chr9_-_89562103 3.580 NM_002048
GAS1
growth arrest-specific 1
chr17_-_39675078 3.578 NM_002275
KRT15
keratin 15
chr11_+_113930430 3.576 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr20_+_327329 3.498 NM_024958
NRSN2
neurensin 2
chr11_-_16497917 3.460 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chrX_-_106960028 3.457 TSC22D3
TSC22 domain family, member 3
chr7_+_144015217 3.433 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr11_-_85430117 3.430 NM_206929
SYTL2
synaptotagmin-like 2
chr19_-_46272496 3.421 NM_175875
SIX5
SIX homeobox 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.31 2.17e-09 GO:0032501 multicellular organismal process
1.48 6.93e-06 GO:0030154 cell differentiation
1.47 8.36e-06 GO:0048869 cellular developmental process
1.32 1.23e-05 GO:0032502 developmental process
1.35 3.38e-05 GO:0048856 anatomical structure development
1.32 8.29e-05 GO:0007275 multicellular organismal development
1.79 8.80e-05 GO:2000026 regulation of multicellular organismal development
1.34 3.60e-04 GO:0048731 system development
1.67 4.72e-04 GO:0050793 regulation of developmental process
1.45 9.29e-04 GO:0003008 system process
1.74 2.41e-03 GO:0045595 regulation of cell differentiation
1.45 6.49e-03 GO:0009653 anatomical structure morphogenesis
2.66 8.27e-03 GO:0006333 chromatin assembly or disassembly
1.97 9.18e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.18 1.29e-02 GO:0090046 regulation of transcription regulator activity
1.57 1.35e-02 GO:0048468 cell development
3.00 1.69e-02 GO:0006334 nucleosome assembly
1.58 1.70e-02 GO:0009888 tissue development
2.85 2.46e-02 GO:0034728 nucleosome organization
2.09 2.46e-02 GO:0051101 regulation of DNA binding
1.36 3.42e-02 GO:0048513 organ development
2.85 3.90e-02 GO:0031497 chromatin assembly
2.53 4.73e-02 GO:0048589 developmental growth
1.81 4.89e-02 GO:0032583 regulation of gene-specific transcription

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.38 7.02e-06 GO:0000786 nucleosome
1.25 1.24e-04 GO:0005886 plasma membrane
1.24 2.78e-04 GO:0071944 cell periphery
2.28 4.08e-04 GO:0000785 chromatin
1.35 7.63e-04 GO:0044459 plasma membrane part
2.56 3.68e-03 GO:0034703 cation channel complex
1.68 3.73e-03 GO:0030054 cell junction
2.91 3.95e-03 GO:0032993 protein-DNA complex
1.15 5.85e-03 GO:0044425 membrane part
1.16 1.17e-02 GO:0031224 intrinsic to membrane
1.16 3.07e-02 GO:0016021 integral to membrane
6.91 3.18e-02 GO:0001518 voltage-gated sodium channel complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.73 1.13e-06 GO:0001071 nucleic acid binding transcription factor activity
1.73 1.13e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.76 1.24e-04 GO:0043565 sequence-specific DNA binding
1.54 1.78e-03 GO:0030528 transcription regulator activity
10.37 1.95e-03 GO:0019864 IgG binding
1.89 2.50e-02 GO:0016563 transcription activator activity
6.05 3.62e-02 GO:0019865 immunoglobulin binding
2.34 4.07e-02 GO:0022843 voltage-gated cation channel activity