Motif ID: GAGGUAG

Z-value: 1.082


Mature miRNA associated with seed GAGGUAG:

NamemiRBase Accession
hsa-let-7a MIMAT0000062
hsa-let-7b MIMAT0000063
hsa-let-7c MIMAT0000064
hsa-let-7d MIMAT0000065
hsa-let-7e MIMAT0000066
hsa-let-7f MIMAT0000067
hsa-let-7g MIMAT0000414
hsa-let-7i MIMAT0000415
hsa-miR-4458 MIMAT0018980
hsa-miR-4500 MIMAT0019036
hsa-miR-98 MIMAT0000096



Activity profile for motif GAGGUAG.

activity profile for motif GAGGUAG


Sorted Z-values histogram for motif GAGGUAG

Sorted Z-values for motif GAGGUAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GAGGUAG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_30454396 10.713 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr5_+_156887026 8.339 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr8_-_124544376 8.032 NM_148177
FBXO32
F-box protein 32
chr8_-_124553448 7.849 NM_001242463
NM_058229
FBXO32

F-box protein 32

chr8_-_22549901 7.406 NM_001199880
EGR3
early growth response 3
chr8_-_22550057 7.366 NM_001199881
EGR3
early growth response 3
chr1_-_115632047 7.358 NM_005725
TSPAN2
tetraspanin 2
chr8_-_22550708 7.212 NM_004430
EGR3
early growth response 3
chr22_-_31688329 6.684 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr3_+_49208979 6.575 NM_173546
KLHDC8B
kelch domain containing 8B
chr14_+_24867926 6.385 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr7_+_22766765 6.188 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr5_+_178450775 6.052 NM_001136116
ZNF879
zinc finger protein 879
chr4_+_74606222 5.820 NM_000584
IL8
interleukin 8
chr9_+_90112754 5.448 NM_004938
DAPK1
death-associated protein kinase 1
chr2_-_1748285 5.097 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr11_-_12030128 4.821 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr18_+_6834431 4.629 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr13_-_110438896 4.460 NM_003749
IRS2
insulin receptor substrate 2
chr17_-_19770988 4.396 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr6_+_138188352 4.228 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_-_24513737 4.144 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr15_-_45670955 4.115 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr15_+_57668702 4.037 NM_001252335
NM_032866
CGNL1

cingulin-like 1

chr22_+_24115035 4.028 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr5_+_42423811 4.013 NM_000163
GHR
growth hormone receptor
chr6_+_106546736 3.962 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr5_+_42424553 3.907 NM_001242399
NM_001242400
GHR

growth hormone receptor

chr12_+_6419601 3.786 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr6_+_106534188 3.765 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr18_+_57567191 3.746 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr15_+_52043738 3.742 NM_001142885
NM_014548
TMOD2

tropomodulin 2 (neuronal)

chr5_-_131347518 3.648 NM_001205248
NM_001205251
NM_001205250
ACSL6


acyl-CoA synthetase long-chain family member 6


chr1_-_108507474 3.617 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr2_+_65216482 3.611 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_-_40367539 3.606 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr12_-_133532847 3.599 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr5_+_42425093 3.522 NM_001242401
GHR
growth hormone receptor
chr3_-_38691118 3.509 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr9_-_73029539 3.432 NM_001206
KLF9
Kruppel-like factor 9
chr5_+_42548144 3.376 NM_001242402
GHR
growth hormone receptor
chr12_+_72666462 3.366 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr3_+_183353355 3.366 NM_017644
KLHL24
kelch-like 24 (Drosophila)
chr5_+_42565963 3.356 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr5_+_42548314 3.352 NM_001242403
GHR
growth hormone receptor
chr15_+_42651697 3.333 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr1_+_111889194 3.301 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr19_-_36980336 3.240 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr1_-_183387501 3.237 NM_015039
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr5_+_42549657 3.186 NM_001242404
GHR
growth hormone receptor
chr19_-_14169970 3.176 NM_001145028
PALM3
paralemmin 3
chr5_-_139726173 3.124 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr8_+_126442557 3.100 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr5_+_42550181 3.072 NM_001242405
GHR
growth hormone receptor
chr3_-_119963141 3.054 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr15_+_42696957 3.050 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr5_+_132149022 2.950 NM_175873
ANKRD43
ankyrin repeat domain 43
chr5_-_131347249 2.944 NM_001009185
NM_001205247
NM_015256
ACSL6


acyl-CoA synthetase long-chain family member 6


chr17_+_57408907 2.913 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr10_-_72142344 2.896 NM_018205
NM_018239
LRRC20

leucine rich repeat containing 20

chr2_+_65215577 2.890 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_-_108231122 2.885 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr10_-_72141347 2.877 NM_207119
LRRC20
leucine rich repeat containing 20
chr1_-_183274008 2.787 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr1_+_164528586 2.777 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr15_+_39873276 2.777 NM_003246
THBS1
thrombospondin 1
chr3_+_16216155 2.730 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr5_+_42565562 2.716 NM_001242406
GHR
growth hormone receptor
chr1_+_155829259 2.698 NM_152280
SYT11
synaptotagmin XI
chr17_+_45331154 2.629 NM_000212
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr15_+_42694587 2.612 NM_173088
CAPN3
calpain 3, (p94)
chr10_+_102732285 2.592 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr11_-_12030882 2.576 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_+_205538111 2.570 NM_181644
MFSD4
major facilitator superfamily domain containing 4
chr5_-_139944045 2.568 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr12_+_6420098 2.560 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr20_+_49348050 2.541 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr5_-_72861376 2.536 NM_023039
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr1_+_160370363 2.428 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr5_+_143550395 2.418 NM_020768
KCTD16
potassium channel tetramerisation domain containing 16
chr11_-_12030622 2.414 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr3_+_121774208 2.376 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chrX_-_119445306 2.286 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr1_+_33722158 2.285 NM_152493
ZNF362
zinc finger protein 362
chr8_+_79428335 2.277 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr2_-_160761266 2.256 NM_001198759
NM_001198760
NM_002349
LY75-CD302

LY75
LY75-CD302 readthrough

lymphocyte antigen 75
chr12_+_6421816 2.250 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr8_-_17658385 2.235 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr6_-_36410665 2.230 NM_152990
PXT1
peroxisomal, testis specific 1
chr6_+_101846860 2.229 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr10_+_72432557 2.215 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr2_+_182321618 2.188 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr3_+_38495778 2.106 NM_001106
ACVR2B
activin A receptor, type IIB
chr12_+_79258448 2.100 NM_005639
SYT1
synaptotagmin I
chr12_+_79257772 2.091 NM_001135805
SYT1
synaptotagmin I
chr4_+_83821835 2.072 NM_024672
THAP9
THAP domain containing 9
chr14_-_90085325 2.070 NM_001085471
FOXN3
forkhead box N3
chr12_-_22487566 2.060 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr12_+_79439432 2.053 NM_001135806
SYT1
synaptotagmin I
chr5_-_172198160 2.024 NM_004417
DUSP1
dual specificity phosphatase 1
chr3_+_121796695 1.978 NM_006889
NM_176892
CD86

CD86 molecule

chr12_-_10324675 1.960 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr3_-_190040192 1.951 NM_021101
CLDN1
claudin 1
chr16_+_639668 1.936 NM_001172664
RAB40C
RAB40C, member RAS oncogene family
chr17_-_7590731 1.935 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr21_-_28217692 1.913 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr13_-_33760215 1.901 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr2_-_214016332 1.893 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr17_+_64960754 1.875 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr16_+_640056 1.875 NM_001172665
NM_001172666
RAB40C

RAB40C, member RAS oncogene family

chr19_-_48867149 1.851 NM_018273
TMEM143
transmembrane protein 143
chr17_-_2304217 1.829 NM_020310
MNT
MAX binding protein
chr11_-_74109417 1.819 NM_173582
PGM2L1
phosphoglucomutase 2-like 1
chr8_-_122653493 1.798 NM_005328
HAS2
hyaluronan synthase 2
chr14_-_89883306 1.785 NM_005197
FOXN3
forkhead box N3
chr9_+_123850573 1.779 NM_007018
CNTRL
centriolin
chr12_-_111021026 1.776 NM_139283
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr13_-_33859835 1.766 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_-_7578810 1.765 NM_001126115
NM_001126116
NM_001126117
TP53


tumor protein p53


chr3_+_102153858 1.755 NM_175056
ZPLD1
zona pellucida-like domain containing 1
chr13_-_96296919 1.739 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr2_-_180129245 1.736 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr13_+_39612440 1.727 NM_001012754
NM_001017370
NHLRC3

NHL repeat containing 3

chr16_+_639356 1.684 NM_001172663
RAB40C
RAB40C, member RAS oncogene family
chr3_-_132441302 1.683 NM_153240
NPHP3-ACAD11
NPHP3
NPHP3-ACAD11 readthrough
nephronophthisis 3 (adolescent)
chr21_+_30671217 1.682 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr14_+_45366426 1.676 NM_001017923
C14orf28
chromosome 14 open reading frame 28
chr8_-_95961543 1.665 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr17_-_38721701 1.658 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_-_74204708 1.636 NM_001144869
LIPT2
lipoyl(octanoyl) transferase 2 (putative)
chr3_-_87040246 1.631 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr1_-_185126153 1.603 NM_001202423
TRMT1L
TRM1 tRNA methyltransferase 1-like
chr3_-_69435429 1.579 NM_015123
FRMD4B
FERM domain containing 4B
chr3_+_50712671 1.565 NM_004947
DOCK3
dedicator of cytokinesis 3
chr1_-_185125819 1.564 NM_030934
TRMT1L
TRM1 tRNA methyltransferase 1-like
chr9_-_77502635 1.563 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr1_+_213123853 1.554 NM_001136474
NM_001136475
NM_024749
VASH2


vasohibin 2


chr16_+_640172 1.545 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr21_+_27107257 1.537 NM_001197297
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr6_+_12290528 1.515 NM_001168319
NM_001955
EDN1

endothelin 1

chr7_-_20826503 1.508 NM_182700
NM_198956
SP8

Sp8 transcription factor

chr7_-_6591066 1.505 NM_001145118
GRID2IP
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein
chr3_-_9291251 1.491 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr11_-_27494232 1.473 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr7_-_112579726 1.473 NM_152556
C7orf60
chromosome 7 open reading frame 60
chr20_-_5591487 1.467 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr8_-_109095836 1.449 NM_178565
RSPO2
R-spondin 2
chr19_-_7293876 1.427 NM_000208
NM_001079817
INSR

insulin receptor

chr21_+_30671736 1.403 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chrX_-_54384436 1.402 NM_001002838
NM_020922
WNK3

WNK lysine deficient protein kinase 3

chr13_-_33780142 1.392 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr3_-_49460110 1.383 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr7_+_20370724 1.381 NM_002214
ITGB8
integrin, beta 8
chr4_+_15004297 1.372 NM_001177381
NM_001177382
NM_001177383
NM_001177384
NM_182485
NM_182646
CPEB2





cytoplasmic polyadenylation element binding protein 2





chr16_+_28303622 1.337 NM_001024401
SBK1
SH3-binding domain kinase 1
chr21_+_27107322 1.314 NM_002040
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr9_+_4662285 1.307 NM_203453
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr10_-_94050799 1.304 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr3_+_107241782 1.291 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr18_+_11751470 1.290 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr12_-_95611023 1.282 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr10_-_61469322 1.250 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr17_-_61777478 1.249 NM_030576
LIMD2
LIM domain containing 2
chr2_+_74881353 1.248 NM_004263
SEMA4F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chr9_+_19408924 1.247 NM_001010887
ACER2
alkaline ceramidase 2
chr20_-_30795346 1.245 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr6_-_134373618 1.238 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr14_+_53019865 1.235 NM_001099652
GPR137C
G protein-coupled receptor 137C
chr12_-_69326946 1.233 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr3_-_36986535 1.225 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr19_+_6531009 1.220 NM_003811
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chr3_+_53529030 1.217 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr13_+_39261172 1.207 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr11_-_16430425 1.204 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr5_-_131132715 1.204 NM_001008738
NM_133372
FNIP1

folliculin interacting protein 1

chr12_-_54673901 1.198 NM_012117
CBX5
chromobox homolog 5
chr1_-_92371558 1.197 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr3_-_143567163 1.192 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr10_-_94003002 1.185 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr9_-_16870719 1.180 NM_017637
BNC2
basonuclin 2
chr5_+_72921980 1.174 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr8_+_104383785 1.161 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr5_-_122759003 1.159 NM_001166226
NM_153223
CEP120

centrosomal protein 120kDa

chr3_+_112051914 1.153 NM_001004196
NM_005944
CD200

CD200 molecule

chr3_+_39851028 1.146 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr1_+_185126191 1.140 NM_001105518
NM_017673
SWT1

SWT1 RNA endoribonuclease homolog (S. cerevisiae)

chr1_+_36273786 1.130 NM_017629
EIF2C4
eukaryotic translation initiation factor 2C, 4
chr11_-_16497917 1.099 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr17_+_34058678 1.099 NM_033315
RASL10B
RAS-like, family 10, member B
chr17_-_65241305 1.090 NM_014877
HELZ
helicase with zinc finger
chr15_+_99192696 1.088 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr5_+_150157507 1.083 NM_032947
C5orf62
chromosome 5 open reading frame 62
chr18_+_21032786 1.081 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr1_-_92351613 1.075 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr1_+_203274646 1.074 NM_006763
BTG2
BTG family, member 2
chr8_-_42751622 1.065 NM_001160223
NM_001160224
NM_001160225
NM_030954
RNF170



ring finger protein 170



chr2_+_86668270 1.046 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr12_-_123451031 1.032 NM_001243013
NM_001243014
NM_019624
NM_019625
NM_203444
ABCB9




ATP-binding cassette, sub-family B (MDR/TAP), member 9




chr9_+_131182690 1.029 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr20_+_37434294 1.028 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.88 4.45e-03 GO:0042127 regulation of cell proliferation
4.84 7.32e-03 GO:0051270 regulation of cellular component movement
6.73 7.70e-03 GO:0030335 positive regulation of cell migration
6.73 7.70e-03 GO:2000147 positive regulation of cell motility
6.50 1.01e-02 GO:0040017 positive regulation of locomotion
6.29 1.32e-02 GO:0051272 positive regulation of cellular component movement
4.93 1.49e-02 GO:0030334 regulation of cell migration
4.87 1.67e-02 GO:2000145 regulation of cell motility
4.45 3.81e-02 GO:0040012 regulation of locomotion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.25 2.25e-02 GO:0005887 integral to plasma membrane
2.21 2.99e-02 GO:0031226 intrinsic to plasma membrane
5.66 3.52e-02 GO:0043235 receptor complex

Nothing significant found in function category.