Motif ID: FOXD3.p2

Z-value: 1.093


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXD3hg19_v1_chr1_+_63789044_63789125-0.308.5e-03Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_13134782 10.225 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_+_30130982 10.095 NM_033229
TRIM15
tripartite motif containing 15
chr7_+_28725597 8.786 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr19_-_5846465 8.616 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr7_+_28475233 7.954 NM_004904
CREB5
cAMP responsive element binding protein 5
chr18_-_47814691 6.484 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr6_+_74171610 6.052 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chr2_-_219031646 5.295 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr7_+_28452143 5.203 NM_182898
CREB5
cAMP responsive element binding protein 5
chr12_+_27175482 4.485 NM_004264
MED21
mediator complex subunit 21
chr1_-_153085963 4.424 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr11_-_67450536 4.206 RPL37
ribosomal protein L37
chr12_-_121735558 4.196 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr12_+_27175501 4.174 MED21
mediator complex subunit 21
chr2_+_102508333 4.106 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr15_-_55800431 4.054 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr6_+_74171453 3.907 NM_001123226
NM_012123
NM_133645
MTO1


mitochondrial translation optimization 1 homolog (S. cerevisiae)


chr11_-_57158103 3.897 NM_001243245
NM_002728
PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

chr8_+_54764367 3.858 NM_170587
RGS20
regulator of G-protein signaling 20
chr1_-_161207879 3.775 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr21_-_27512668 3.765 NM_001136016
APP
amyloid beta (A4) precursor protein
chr9_+_105757592 3.714 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr12_+_112890999 3.610 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr19_+_36486042 3.604 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr5_+_147582338 3.534 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr10_-_931694 3.527 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr19_+_15160194 3.516 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr22_-_43036606 3.464 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr1_+_84630575 3.447 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr5_+_92918924 3.430 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr4_-_76878558 3.424 SDAD1
SDA1 domain containing 1
chr2_-_47134945 3.366 MCFD2
multiple coagulation factor deficiency 2
chr12_-_121736110 3.351 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr15_+_32933869 3.350 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr15_-_65412175 3.297 PDCD7
programmed cell death 7
chr3_-_15382874 3.288 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr14_-_101036130 3.254 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr4_+_146031528 3.239 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr16_+_30064470 3.232 ALDOA
aldolase A, fructose-bisphosphate
chr20_+_43990576 3.204 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr3_-_27764197 3.166 EOMES
eomesodermin
chr8_+_86099909 3.161 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr13_+_28494136 3.092 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr16_+_30064410 3.083 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr14_-_34419957 3.071 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr12_+_105153258 3.038 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_-_122018100 3.012 NM_001005366
KDM2B
lysine (K)-specific demethylase 2B
chr4_-_186456580 2.956 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr20_+_123230 2.917 NM_030931
DEFB126
defensin, beta 126
chr10_-_45474210 2.893 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr9_+_102677457 2.858 STX17
syntaxin 17
chr16_+_27341305 2.850 IL4R
interleukin 4 receptor
chr5_+_71502700 2.813 MAP1B
microtubule-associated protein 1B
chr19_+_1026271 2.775 NM_004368
NM_201277
CNN2

calponin 2

chr11_-_17191287 2.731 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr9_+_127054246 2.703 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr7_+_28530747 2.682 CREB5
cAMP responsive element binding protein 5
chr6_+_45296053 2.631 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr5_+_34687663 2.609 NM_001145523
RAI14
retinoic acid induced 14
chr7_+_134576187 2.596 CALD1
caldesmon 1
chr1_-_231005334 2.584 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr6_+_121756744 2.567 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chrX_-_102942968 2.512 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr1_-_7973286 2.498 UTS2
urotensin 2
chr3_+_51575595 2.456 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr17_+_57743498 2.446 CLTC
clathrin, heavy chain (Hc)
chr21_-_43346780 2.419 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr14_-_99737554 2.383 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr16_-_47005339 2.382 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr11_+_12308446 2.357 NM_032867
MICALCL
MICAL C-terminal like
chr14_+_67831484 2.354 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr15_-_75194542 2.350 C15orf17
chromosome 15 open reading frame 17
chr21_+_39628869 2.347 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_-_28124915 2.320 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_+_102508377 2.315 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_-_33473919 2.288 NM_022917
NM_139235
NOL6

nucleolar protein family 6 (RNA-associated)

chr5_-_114515733 2.285 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr1_-_32281577 2.277 NM_144569
SPOCD1
SPOC domain containing 1
chr6_+_150263120 2.274 NM_025217
ULBP2
UL16 binding protein 2
chr9_-_86082656 2.267 NM_001244960
FRMD3
FERM domain containing 3
chr5_+_147691988 2.219 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr18_+_61554938 2.211 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr16_-_28437663 2.210 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr16_+_70380763 2.202 NM_018332
DDX19A
DEAD (Asp-Glu-Ala-As) box polypeptide 19A
chr11_+_46383115 2.200 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr17_-_42144986 2.195 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_150480486 2.192 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr2_+_102953716 2.192 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr2_-_72374919 2.188 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr16_-_279338 2.178 NM_018032
NM_201412
LUC7L

LUC7-like (S. cerevisiae)

chr6_+_151561571 2.170


chr13_-_110802708 2.163 COL4A1
collagen, type IV, alpha 1
chr12_+_47610051 2.154 NM_138371
FAM113B
family with sequence similarity 113, member B
chr22_+_46449674 2.144


chr1_+_152486977 2.124 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr3_+_11267666 2.102 NM_001098211
HRH1
histamine receptor H1
chr9_+_103340335 2.101 NM_001018116
MURC
muscle-related coiled-coil protein
chr5_-_64777703 2.076 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr8_+_132991171 2.076 EFR3A
EFR3 homolog A (S. cerevisiae)
chr8_+_23427477 2.073 SLC25A37
solute carrier family 25, member 37
chr11_+_45825622 2.070 NM_001145265
NM_001145266
SLC35C1

solute carrier family 35, member C1

chr12_+_64803741 2.051 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_132316080 2.051 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr11_+_69467210 2.037 CCND1
cyclin D1
chr16_+_28699878 2.020 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr3_-_47933997 2.018 MAP4
microtubule-associated protein 4
chr9_-_100935173 2.007 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr22_-_25777543 1.999 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr12_+_9980076 1.998 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr9_-_140142165 1.989 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr5_+_126859157 1.980 PRRC1
proline-rich coiled-coil 1
chr2_+_109204777 1.972 LIMS1
LIM and senescent cell antigen-like domains 1
chr18_-_61329113 1.969 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr15_-_42749710 1.967 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr12_+_56915587 1.960 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr3_+_38263076 1.956 OXSR1
oxidative-stress responsive 1
chr13_+_99058147 1.938


chr17_-_3599298 1.924 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr4_-_139163222 1.921 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr12_+_50869531 1.921 LARP4
La ribonucleoprotein domain family, member 4
chr7_+_89783688 1.915 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr15_-_66648991 1.878 NM_017858
TIPIN
TIMELESS interacting protein
chr22_-_45609314 1.871 KIAA0930
KIAA0930
chr6_+_151561653 1.870 AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_130700762 1.857 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr1_-_161147757 1.855 NM_001199873
NM_001199874
NM_003779
B4GALT3


UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3


chr4_-_83347222 1.848 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr10_-_99161013 1.847 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chrX_-_62570968 1.842 NM_001012968
SPIN4
spindlin family, member 4
chr3_-_42843217 1.836


chr1_+_40735749 1.833 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr12_-_52779362 1.831 NM_033045
KRT84
keratin 84
chrX_-_76937157 1.829 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr1_-_57045235 1.826 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr7_-_22539795 1.824 NM_001164460
NM_207342
STEAP1B

STEAP family member 1B

chr9_-_117156684 1.816 NM_030767
AKNA
AT-hook transcription factor
chr9_+_127962850 1.812 NM_005833
RABEPK
Rab9 effector protein with kelch motifs
chr9_+_125137600 1.805 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr16_-_4323000 1.804 NM_003223
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr16_-_4322695 1.800 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr1_+_24840800 1.799 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr16_-_90076528 1.798 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr15_+_96876568 1.774 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr5_+_132406080 1.773 HSPA4
heat shock 70kDa protein 4
chr5_+_147795459 1.761 FBXO38
F-box protein 38
chr17_-_3599359 1.756 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr12_+_95676175 1.755 VEZT
vezatin, adherens junctions transmembrane protein
chr19_+_10362598 1.749 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chr2_-_242556883 1.742 NM_001164356
THAP4
THAP domain containing 4
chr13_+_24734788 1.741 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chr8_+_144731829 1.732 NM_014789
ZNF623
zinc finger protein 623
chr2_+_109204904 1.730 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr9_+_137004913 1.728 NM_052821
WDR5
WD repeat domain 5
chr12_+_26126687 1.727 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr19_-_54692132 1.725 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr10_+_49609641 1.699 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr1_+_84630374 1.698 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr13_-_75901897 1.696 TBC1D4
TBC1 domain family, member 4
chr9_-_99775855 1.681 HIATL2
hippocampus abundant transcript-like 2
chr4_-_39523132 1.678 UGDH
UDP-glucose 6-dehydrogenase
chr10_-_14816895 1.676 NM_031453
FAM107B
family with sequence similarity 107, member B
chr13_+_21183940 1.676


chr7_+_129269916 1.674 NM_001040110
NRF1
nuclear respiratory factor 1
chr2_-_216242916 1.667 FN1
fibronectin 1
chr4_+_71587674 1.667 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr15_+_69606741 1.636 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr18_+_33234532 1.632 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr3_-_52090090 1.619 NM_001947
DUSP7
dual specificity phosphatase 7
chr15_+_100173182 1.618 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr12_-_8088629 1.608 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr5_+_40841296 1.608 NM_032587
CARD6
caspase recruitment domain family, member 6
chr18_-_52626636 1.605 NM_025214
CCDC68
coiled-coil domain containing 68
chr6_+_151561508 1.601 AKAP12
A kinase (PRKA) anchor protein 12
chr17_-_8424217 1.596 MYH10
myosin, heavy chain 10, non-muscle
chr5_+_68800003 1.595 NM_001205255
OCLN
occludin
chr7_+_134576150 1.595 NM_033139
NM_033140
CALD1

caldesmon 1

chr2_+_12857885 1.594 TRIB2
tribbles homolog 2 (Drosophila)
chr13_-_49975734 1.594 NM_030925
CAB39L
calcium binding protein 39-like
chr1_-_168106810 1.591 GPR161
G protein-coupled receptor 161
chr6_+_158733691 1.590 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr8_+_66582107 1.588 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr11_+_62186506 1.573 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr15_-_55562483 1.566 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr17_+_40925473 1.563 VPS25
vacuolar protein sorting 25 homolog (S. cerevisiae)
chr10_-_33623771 1.557 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr19_-_45996470 1.550 NM_206901
RTN2
reticulon 2
chr19_-_16250695 1.550


chr10_-_32667543 1.540 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr16_+_69726751 1.540 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_-_94417185 1.531 MCTP1
multiple C2 domains, transmembrane 1
chr12_-_80307690 1.523 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr1_+_44064509 1.522 PTPRF
protein tyrosine phosphatase, receptor type, F
chr16_+_29086269 1.522 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr15_-_40600118 1.518 NM_004573
PLCB2
phospholipase C, beta 2
chr9_+_27109138 1.510 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr17_+_40925443 1.507 NM_032353
VPS25
vacuolar protein sorting 25 homolog (S. cerevisiae)
chr6_-_136847609 1.474 MAP7
microtubule-associated protein 7
chr3_-_111314181 1.472 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr1_+_244216506 1.468 NM_006352
ZNF238
zinc finger protein 238
chr2_+_170335948 1.454 NM_152384
BBS5
Bardet-Biedl syndrome 5

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
20.11 8.66e-03 GO:0042800 histone methyltransferase activity (H3-K4 specific)