Motif ID: FOXA2.p3

Z-value: 1.131


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXA2hg19_v1_chr20_-_22565050_225651000.513.4e-06Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_15160194 11.815 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr1_+_152486977 10.118 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr7_+_28338939 5.521 NM_182899
CREB5
cAMP responsive element binding protein 5
chr21_-_31588242 4.668 NM_199328
CLDN8
claudin 8
chr12_-_57328044 4.557 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr12_+_55248298 4.540 NM_058173
MUCL1
mucin-like 1
chr12_-_76425375 4.532 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr5_-_142065991 4.439 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr12_-_53074172 4.340 NM_006121
KRT1
keratin 1
chr7_+_28452143 4.292 NM_182898
CREB5
cAMP responsive element binding protein 5
chr3_+_178276487 3.889 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr3_+_151488214 3.857 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr10_+_51549552 3.486 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr3_-_193272587 3.445 NM_032279
ATP13A4
ATPase type 13A4
chr17_-_26697224 3.441 VTN
vitronectin
chr12_-_772525 3.362 NM_016533
NINJ2
ninjurin 2
chr17_-_26697310 3.343 VTN
vitronectin
chr3_+_46653924 3.315 NM_001195442
LOC100132146
uncharacterized LOC100132146
chr5_-_142065586 3.284 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr4_+_15429628 3.202 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr18_+_61254533 3.175 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr7_+_113726364 3.162 FOXP2
forkhead box P2
chr4_+_70861647 3.148 NM_001009181
NM_003154
STATH

statherin

chr2_+_11674241 3.056 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr4_+_15376174 2.982 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr11_+_3666357 2.914 NM_004314
ART1
ADP-ribosyltransferase 1
chr17_-_26697358 2.901 NM_000638
VTN
vitronectin
chr1_+_86934525 2.890 NM_001285
CLCA1
chloride channel accessory 1
chr10_+_101542554 2.834 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr11_-_6790187 2.824 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr17_-_26697293 2.793 VTN
vitronectin
chr7_+_113726592 2.716 FOXP2
forkhead box P2
chr16_+_29789560 2.686 NM_152338
ZG16
zymogen granule protein 16 homolog (rat)
chr5_+_27472382 2.654 LOC643401
uncharacterized LOC643401
chr1_-_177939049 2.637 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr12_-_7596722 2.626 NM_174941
CD163L1
CD163 molecule-like 1
chr7_-_50628744 2.602 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr12_+_124773709 2.592 NM_181709
FAM101A
family with sequence similarity 101, member A
chr12_-_89746238 2.589 DUSP6
dual specificity phosphatase 6
chr18_+_32335939 2.566 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr1_-_103496768 2.552 COL11A1
collagen, type XI, alpha 1
chr10_-_50396380 2.544 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr20_-_50179167 2.536 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr2_-_102091164 2.527 NM_001145664
RFX8
regulatory factor X, 8
chr6_-_88875766 2.522 NM_001160226
NM_001160258
NM_001160259
NM_016083
CNR1



cannabinoid receptor 1 (brain)



chr17_-_3195875 2.522 NM_002550
OR3A1
olfactory receptor, family 3, subfamily A, member 1
chr9_+_140125384 2.497 NM_080877
SLC34A3
solute carrier family 34 (sodium phosphate), member 3
chr18_+_28898051 2.482 NM_001942
DSG1
desmoglein 1
chr12_-_89745997 2.468 DUSP6
dual specificity phosphatase 6
chr6_-_46922533 2.456 NM_015234
GPR116
G protein-coupled receptor 116
chr6_+_131148544 2.456 NM_001195597
LOC100507203
uncharacterized LOC100507203
chr19_-_18902077 2.429 NM_000095
COMP
cartilage oligomeric matrix protein
chr6_-_41715078 2.408 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr3_+_186714335 2.403


chr4_+_187148624 2.391 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chrX_+_26156459 2.384 NM_173699
MAGEB18
melanoma antigen family B, 18
chr13_-_99959649 2.380 NM_004951
GPR183
G protein-coupled receptor 183
chrX_+_47863733 2.341 NM_205856
SPACA5
sperm acrosome associated 5
chr3_-_190167597 2.324 NM_207316
TMEM207
transmembrane protein 207
chr5_-_156772672 2.323 NM_001001343
FNDC9
fibronectin type III domain containing 9
chr10_+_101542460 2.323 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr14_-_101036130 2.320 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr14_+_21359542 2.316 NM_002935
RNASE3
ribonuclease, RNase A family, 3
chr1_+_200011716 2.314 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr4_+_15341559 2.309 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chrX_-_6145887 2.281 NM_020742
NLGN4X
neuroligin 4, X-linked
chr6_-_112575880 2.279 LAMA4
laminin, alpha 4
chr2_-_134326030 2.268 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr21_-_40033617 2.228 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr20_+_54823787 2.217 NM_019888
MC3R
melanocortin 3 receptor
chr17_+_72931813 2.216 NM_178233
OTOP3
otopetrin 3
chr18_+_29769986 2.206 NM_005925
MEP1B
meprin A, beta
chr18_-_3874688 2.203 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr1_-_120354058 2.166 NM_001159352
NM_001159353
NM_032044
REG4


regenerating islet-derived family, member 4


chr10_-_81320141 2.157 NM_001098668
SFTPA1
SFTPA2
surfactant protein A1
surfactant protein A2
chr4_-_72671236 2.147 NM_001204306
GC
group-specific component (vitamin D binding protein)
chr3_+_171561138 2.130 NM_001164436
TMEM212
transmembrane protein 212
chrX_+_115301957 2.118 NM_000686
AGTR2
angiotensin II receptor, type 2
chr10_-_21435487 2.114 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr6_-_31845446 2.110 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr2_-_21230572 2.108 APOB
apolipoprotein B (including Ag(x) antigen)
chr8_+_75736771 2.106 NM_015886
PI15
peptidase inhibitor 15
chr17_-_9923204 2.103 GAS7
growth arrest-specific 7
chr17_-_10452939 2.091 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr7_+_31003635 2.086 NM_000823
GHRHR
growth hormone releasing hormone receptor
chrX_+_135730335 2.080 NM_000074
CD40LG
CD40 ligand
chr19_-_54311958 2.078 NM_033297
NLRP12
NLR family, pyrin domain containing 12
chrX_-_15333726 2.077 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr20_-_49308074 2.075


chr1_-_160492982 2.063 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr7_+_106505876 2.059 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr6_-_90024936 2.055 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr3_+_174577069 2.048 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr19_+_15726028 2.046 NM_007253
CYP4F8
cytochrome P450, family 4, subfamily F, polypeptide 8
chr3_+_64670779 2.038 ADAMTS9-AS2
ADAMTS9 antisense RNA 2 (non-protein coding)
chr12_-_21487831 2.037 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr20_+_62795826 2.035 NM_004535
MYT1
myelin transcription factor 1
chr1_-_115238091 2.029 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr20_-_7921068 2.022 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr5_-_135701163 2.017 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr6_+_55039070 2.006 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr10_-_54531394 1.999 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr4_+_71019903 1.983 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr22_-_17700265 1.983 CECR1
cat eye syndrome chromosome region, candidate 1
chr1_-_203320185 1.976 FMOD
fibromodulin
chr7_+_106505696 1.968 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chrX_+_91089658 1.960 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr7_+_136553398 1.956 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr14_-_36988902 1.955 NM_003317
NKX2-1
NK2 homeobox 1
chr8_-_82443549 1.949 NM_001105281
FABP12
fatty acid binding protein 12
chr12_-_71551564 1.945 TSPAN8
tetraspanin 8
chr19_+_45909466 1.940 NM_012099
CD3EAP
CD3e molecule, epsilon associated protein
chr1_-_20306908 1.936 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr5_+_54398473 1.935 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr11_-_34535302 1.935 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr1_-_178840079 1.930 NM_004673
ANGPTL1
angiopoietin-like 1
chr11_-_10673832 1.915 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr12_-_89746244 1.914 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr1_-_203320249 1.908


chr20_-_55841671 1.907 NM_001719
BMP7
bone morphogenetic protein 7
chr12_+_21525801 1.894 NM_000415
IAPP
islet amyloid polypeptide
chr6_-_127780534 1.894 NM_014702
KIAA0408
KIAA0408
chr12_-_9268440 1.892 A2M
alpha-2-macroglobulin
chr1_-_157811491 1.891 NM_005894
CD5L
CD5 molecule-like
chr20_-_52687014 1.891 BCAS1
breast carcinoma amplified sequence 1
chr2_-_169887832 1.888 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr18_-_48351732 1.878 NM_001127174
MRO
maestro
chr12_-_9268475 1.876 A2M
alpha-2-macroglobulin
chr3_-_3152057 1.869 NM_000564
NM_001243099
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA






interleukin 5 receptor, alpha






chr17_-_9923323 1.864 GAS7
growth arrest-specific 7
chr15_-_40599974 1.864 PLCB2
phospholipase C, beta 2
chr1_-_203320287 1.862 NM_002023
FMOD
fibromodulin
chr4_-_71532206 1.861 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr6_-_112575766 1.857 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr11_-_116663106 1.853 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr12_-_9268513 1.851 A2M
alpha-2-macroglobulin
chr2_-_100722328 1.850 AFF3
AF4/FMR2 family, member 3
chr17_-_77478562 1.845 NM_001082575
RBFOX3
RNA binding protein, fox-1 homolog (C. elegans) 3
chrX_+_123480131 1.843 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr1_+_86889768 1.837 NM_006536
CLCA2
chloride channel accessory 2
chr4_-_71532341 1.831 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr7_+_80267922 1.814 CD36
CD36 molecule (thrombospondin receptor)
chr14_-_94789641 1.811 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr1_+_40713572 1.805 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr3_-_193096513 1.802 NM_198505
ATP13A5
ATPase type 13A5
chr2_-_65159566 1.800 LOC400958
uncharacterized LOC400958
chr7_-_115670774 1.798 TFEC
transcription factor EC
chr1_-_152332481 1.796 NM_001014342
FLG2
filaggrin family member 2
chr4_+_88720701 1.787 NM_004967
IBSP
integrin-binding sialoprotein
chr4_+_68424444 1.781 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_+_16330730 1.776 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr9_-_14910992 1.776 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr16_-_21663962 1.775 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr7_+_143771274 1.755 NM_001004488
OR2A25
olfactory receptor, family 2, subfamily A, member 25
chr15_-_70341870 1.753 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr7_+_80267782 1.752 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chrX_-_6146655 1.747 NM_181332
NLGN4X
neuroligin 4, X-linked
chr18_+_52258389 1.747 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr18_+_32073343 1.744 DTNA
dystrobrevin, alpha
chr5_+_147691988 1.743 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr1_+_222910557 1.734 NM_207468
FAM177B
family with sequence similarity 177, member B
chr8_-_134072404 1.734 NM_006748
SLA
Src-like-adaptor
chr7_+_129906702 1.734 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr14_-_70263871 1.731 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr7_+_143140545 1.726 NM_177437
TAS2R60
taste receptor, type 2, member 60
chr7_+_106505739 1.725 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_+_112924284 1.721 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr11_+_62186506 1.721 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr20_+_43935490 1.719 NM_014276
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like
chr1_+_24645811 1.712 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr11_+_71276608 1.705 NM_001012710
KRTAP5-10
keratin associated protein 5-10
chr4_-_68621803 1.702 NM_000406
NM_001012763
GNRHR

gonadotropin-releasing hormone receptor

chr3_+_186330844 1.701 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr1_+_172389827 1.699 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr1_-_238054221 1.698 NM_021186
ZP4
zona pellucida glycoprotein 4
chr1_-_67266930 1.697 NM_005478
INSL5
insulin-like 5
chr12_+_121416548 1.696 NM_000545
HNF1A
HNF1 homeobox A
chr11_+_94758421 1.695 NM_001161630
KDM4DL
lysine (K)-specific demethylase 4D-like
chr7_-_115608366 1.694 NM_001244583
TFEC
transcription factor EC
chr4_+_175839508 1.691 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr2_-_96987618 1.689


chrX_+_78003205 1.685 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr6_+_144185572 1.684 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr10_-_102890902 1.682 NM_001085398
TLX1NB
TLX1 neighbor
chr5_-_169724782 1.680 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_+_124120422 1.679 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr10_+_102891060 1.677 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr4_+_187187117 1.676 NM_000128
F11
coagulation factor XI
chr1_+_152730505 1.651 NM_001025231
KPRP
keratinocyte proline-rich protein
chr18_+_904943 1.642 NM_001099733
ADCYAP1
adenylate cyclase activating polypeptide 1 (pituitary)
chr7_+_123295860 1.638 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr7_-_107443631 1.625 NM_000111
SLC26A3
solute carrier family 26, member 3
chr3_+_186330859 1.617 AHSG
alpha-2-HS-glycoprotein
chr5_-_36301999 1.614 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr13_-_61989654 1.613 NM_022843
PCDH20
protocadherin 20
chr5_-_169724817 1.597 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr15_+_75550898 1.595 NM_001164404
GOLGA6A
GOLGA6C
golgin A6 family, member A
golgin A6 family, member C
chr11_-_107582733 1.590 NM_003063
SLN
sarcolipin
chr12_+_10034087 1.585 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr3_+_70048882 1.582



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
13.21 2.11e-05 GO:0030193 regulation of blood coagulation
16.36 2.13e-05 GO:0030195 negative regulation of blood coagulation
15.79 2.90e-05 GO:0050819 negative regulation of coagulation
12.27 4.24e-05 GO:0050818 regulation of coagulation
10.74 1.46e-04 GO:0061041 regulation of wound healing
4.44 1.68e-04 GO:0051241 negative regulation of multicellular organismal process
1.49 3.11e-04 GO:0032501 multicellular organismal process
4.47 3.50e-04 GO:0032101 regulation of response to external stimulus
3.04 1.02e-03 GO:0080134 regulation of response to stress
1.41 1.31e-03 GO:0050896 response to stimulus
10.83 3.57e-03 GO:0008206 bile acid metabolic process
3.06 4.29e-03 GO:0050776 regulation of immune response
17.89 6.90e-03 GO:0015721 bile acid and bile salt transport
8.35 2.17e-02 GO:0045807 positive regulation of endocytosis
42.94 2.45e-02 GO:0031639 plasminogen activation
4.70 2.77e-02 GO:0006820 anion transport
3.38 2.79e-02 GO:0050778 positive regulation of immune response
2.64 2.81e-02 GO:0007186 G-protein coupled receptor protein signaling pathway
2.57 2.90e-02 GO:0042060 wound healing

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.31 1.34e-10 GO:0005576 extracellular region
2.78 2.50e-08 GO:0044421 extracellular region part
1.59 1.35e-05 GO:0005886 plasma membrane
1.59 1.48e-05 GO:0071944 cell periphery
2.69 1.57e-05 GO:0005615 extracellular space
2.23 5.24e-05 GO:0005887 integral to plasma membrane
3.49 6.30e-05 GO:0031012 extracellular matrix
2.19 8.85e-05 GO:0031226 intrinsic to plasma membrane
1.77 5.94e-04 GO:0044459 plasma membrane part
1.40 1.41e-03 GO:0016021 integral to membrane
1.39 2.25e-03 GO:0031224 intrinsic to membrane
3.18 4.44e-03 GO:0005578 proteinaceous extracellular matrix
1.25 2.42e-02 GO:0016020 membrane
1.29 3.24e-02 GO:0044425 membrane part
6.61 4.31e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.30 5.31e-04 GO:0030246 carbohydrate binding
5.68 1.08e-03 GO:0008201 heparin binding
4.68 2.96e-03 GO:0008509 anion transmembrane transporter activity
1.98 5.73e-03 GO:0004888 transmembrane receptor activity
1.82 6.89e-03 GO:0004872 receptor activity
7.29 1.28e-02 GO:0042562 hormone binding
4.29 1.55e-02 GO:0005539 glycosaminoglycan binding
15.27 2.99e-02 GO:0008514 organic anion transmembrane transporter activity
3.96 3.14e-02 GO:0001871 pattern binding
3.96 3.14e-02 GO:0030247 polysaccharide binding
14.31 3.93e-02 GO:0015125 bile acid transmembrane transporter activity