Motif ID: FOX{C1,C2}.p2

Z-value: 0.698


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXC1hg19_v1_chr6_+_1611544_16116050.291.2e-02Click!
FOXC2hg19_v1_chr16_+_86600856_86600856-0.217.1e-02Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_35230548 2.671 PRLR
prolactin receptor
chrX_-_63450486 2.300 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr2_-_119605758 2.277 NM_001426
EN1
engrailed homeobox 1
chr19_-_36054559 2.218 NM_000704
ATP4A
ATPase, H+/K+ exchanging, alpha polypeptide
chr13_-_99959649 2.058 NM_004951
GPR183
G protein-coupled receptor 183
chr17_-_16875388 2.029 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr11_-_2156721 1.944 IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_+_71019903 1.941 NM_214711
C4orf40
chromosome 4 open reading frame 40
chrX_-_130423199 1.932 IGSF1
immunoglobulin superfamily, member 1
chr12_-_25706177 1.882 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr15_+_86685241 1.861 NM_152336
AGBL1
ATP/GTP binding protein-like 1
chr1_+_152691997 1.855 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr5_+_147715121 1.779 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr6_-_169650846 1.751


chr16_+_56598960 1.667 NM_032935
MT4
metallothionein 4
chr2_-_158300517 1.662 NM_004288
CYTIP
cytohesin 1 interacting protein
chr9_+_107456659 1.651 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr11_+_118175294 1.629 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr1_-_68915631 1.623 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr19_+_15197790 1.616 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr18_-_56296188 1.611 NM_052947
ALPK2
alpha-kinase 2
chr13_-_53313924 1.572 NM_001011705
NM_007015
LECT1

leukocyte cell derived chemotaxin 1

chr1_-_157522151 1.561 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr3_-_114343791 1.549 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr21_+_43823970 1.520 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chr15_-_58306185 1.509 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr2_-_233641225 1.508 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr1_-_202129731 1.502 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr12_+_69742140 1.494 LYZ
lysozyme
chr20_+_42984338 1.481 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_+_12717036 1.458 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr11_-_114430579 1.451 NM_152315
FAM55A
family with sequence similarity 55, member A
chrX_-_108725284 1.441 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr12_+_25205488 1.430 LRMP
lymphoid-restricted membrane protein
chr1_+_199996729 1.421 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr12_+_69742130 1.408 NM_000239
LYZ
lysozyme
chr12_+_8325149 1.369 NM_001004328
ZNF705A
zinc finger protein 705A
chr12_+_100867739 1.365 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_-_117150197 1.354 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr1_-_162381805 1.333 NM_053282
SH2D1B
SH2 domain containing 1B
chr18_+_43304143 1.320 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chrX_+_125953746 1.320 NM_001122716
CXorf64
chromosome X open reading frame 64
chr2_+_189839113 1.319 COL3A1
collagen, type III, alpha 1
chr3_+_45927995 1.310 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr15_+_78384926 1.302 NM_001101404
SH2D7
SH2 domain containing 7
chrX_+_26156459 1.295 NM_173699
MAGEB18
melanoma antigen family B, 18
chr12_-_102872329 1.286 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_-_87969135 1.277 LINC00461
long intergenic non-protein coding RNA 461
chr6_-_152702329 1.251 SYNE1
spectrin repeat containing, nuclear envelope 1
chr20_-_61002588 1.231 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr11_+_66790815 1.231 NM_177963
SYT12
synaptotagmin XII
chr2_+_189839132 1.223 COL3A1
collagen, type III, alpha 1
chr10_+_7745354 1.221 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_133495925 1.219 TF
transferrin
chr10_+_7745341 1.201 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr20_-_44168128 1.186 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr8_+_55528626 1.173 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr5_-_35230822 1.173 NM_000949
PRLR
prolactin receptor
chr3_-_119278402 1.156 NM_005191
CD80
CD80 molecule
chrX_+_115301957 1.147 NM_000686
AGTR2
angiotensin II receptor, type 2
chr5_+_173472692 1.126 NM_015980
HMP19
HMP19 protein
chr11_-_62688732 1.114 CHRM1
cholinergic receptor, muscarinic 1
chr6_+_12716887 1.101 PHACTR1
phosphatase and actin regulator 1
chr10_-_17171789 1.100 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr19_-_14952688 1.082 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr17_-_41836132 1.081 NM_025237
SOST
sclerostin
chr6_+_47624222 1.073 NM_153839
GPR111
G protein-coupled receptor 111
chr17_-_80797889 1.068 NM_024702
ZNF750
zinc finger protein 750
chr2_+_189839078 1.065 NM_000090
COL3A1
collagen, type III, alpha 1
chr5_+_176057682 1.061 NM_001099408
EIF4E1B
eukaryotic translation initiation factor 4E family member 1B
chr11_-_59633942 1.052 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr14_+_88471467 1.038 NM_003608
GPR65
G protein-coupled receptor 65
chr10_-_99790346 1.037 CRTAC1
cartilage acidic protein 1
chr10_+_7745284 1.030 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 1.023 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr20_-_44175995 1.018 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr5_+_173472737 1.017 HMP19
HMP19 protein
chr6_-_159466019 1.016 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr18_+_32335939 1.016 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr3_-_116164363 1.005 NM_002338
LSAMP
limbic system-associated membrane protein
chr12_+_100867550 0.998 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr13_-_53313835 0.997 LECT1
leukocyte cell derived chemotaxin 1
chr3_-_170303774 0.992 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr2_+_48796158 0.991 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr6_-_41122025 0.982 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr6_+_72926144 0.977 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr8_-_27115935 0.974 STMN4
stathmin-like 4
chr1_+_198608136 0.962 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_-_117799410 0.961 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr7_-_55930444 0.959 NM_207366
SEPT14
septin 14
chr17_-_39093671 0.956 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_7082559 0.956 ASGR1
asialoglycoprotein receptor 1
chr10_+_96522457 0.955 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr8_-_86290333 0.950 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr3_-_194090459 0.937 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr4_+_15376174 0.937 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr18_+_28898051 0.933 NM_001942
DSG1
desmoglein 1
chr4_+_186350543 0.931 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr17_-_64225496 0.914 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_64669489 0.902 NM_152489
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr13_+_52034639 0.901


chr1_-_198906536 0.898 LOC100131234
familial acute myelogenous leukemia related factor
chr1_-_208084379 0.894 CD34
CD34 molecule
chr2_+_1418179 0.888 NM_175721
NM_175722
TPO

thyroid peroxidase

chr9_-_104198045 0.877 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr10_+_96698409 0.857 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr10_+_7745229 0.854 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_46125929 0.849 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr4_+_74281884 0.848 ALB
albumin
chr5_+_140474198 0.837 NM_018936
PCDHB2
protocadherin beta 2
chr22_+_51176623 0.835 NM_001097
ACR
acrosin
chr14_+_74815194 0.818 VRTN
vertebrae development homolog (pig)
chr19_+_15052298 0.813 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr1_-_24239758 0.808 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr7_+_129906702 0.804 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr2_+_137748461 0.798 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr9_+_125281418 0.796 NM_001004452
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr9_+_140145712 0.793 NM_001004353
C9orf173
chromosome 9 open reading frame 173
chr16_-_72206023 0.792 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr7_-_92848837 0.791 NM_198151
HEPACAM2
HEPACAM family member 2
chr11_-_16996559 0.785 RPL36A
ribosomal protein L36a
chrX_+_15525430 0.780 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr1_-_157670280 0.780 NM_052939
FCRL3
Fc receptor-like 3
chr7_-_50628744 0.780 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr3_+_127634317 0.775 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr18_+_52258389 0.775 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr12_+_52306112 0.775 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr7_-_50633042 0.773 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr10_-_7708805 0.769 NM_001001851
NM_030569
ITIH5

inter-alpha-trypsin inhibitor heavy chain family, member 5

chrX_+_106163605 0.763 NM_020384
CLDN2
claudin 2
chr11_+_114549199 0.741 NM_182495
FAM55B
family with sequence similarity 55, member B
chr2_+_74120092 0.738 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chrX_+_41548225 0.722 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr19_+_42221404 0.717 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr20_+_2276612 0.709 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_+_198608216 0.708 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_48687282 0.702 NM_181532
ERAS
ES cell expressed Ras
chr1_-_168698412 0.699 NM_001937
DPT
dermatopontin
chr1_+_120049825 0.697 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr16_+_78062985 0.694 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr3_+_64670779 0.693 ADAMTS9-AS2
ADAMTS9 antisense RNA 2 (non-protein coding)
chr5_-_156535993 0.684 HAVCR2
hepatitis A virus cellular receptor 2
chrX_-_130423387 0.680 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr12_-_9913415 0.679 NM_001781
CD69
CD69 molecule
chr1_+_163038934 0.675 NM_001113381
RGS4
regulator of G-protein signaling 4
chr22_-_30662787 0.674 NM_020530
OSM
oncostatin M
chr3_+_169629359 0.670 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr1_+_152943127 0.670 NM_173080
SPRR4
small proline-rich protein 4
chr14_+_74815165 0.663 NM_018228
VRTN
vertebrae development homolog (pig)
chr2_+_33701678 0.660 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_247751661 0.654 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr1_+_26485510 0.649 NM_024869
FAM110D
family with sequence similarity 110, member D
chr8_-_124749573 0.646 NM_001003954
NM_004306
ANXA13

annexin A13

chr3_-_164914448 0.646 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr7_+_31003635 0.645 NM_000823
GHRHR
growth hormone releasing hormone receptor
chr11_+_62009723 0.643 NM_006551
SCGB1D2
secretoglobin, family 1D, member 2
chr1_+_196857143 0.643 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr22_+_50925212 0.641 NM_017584
MIOX
myo-inositol oxygenase
chr3_+_118892363 0.639 NM_006952
UPK1B
uroplakin 1B
chr3_+_108541544 0.637 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr2_+_179184970 0.637 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr11_-_16497917 0.635 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr10_-_7682741 0.634 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr21_+_31768294 0.632 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr7_-_14880954 0.629 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr11_-_133715368 0.613 NM_174927
SPATA19
spermatogenesis associated 19
chr4_+_169013687 0.613 NM_007193
ANXA10
annexin A10
chr3_-_147122070 0.611 NM_001168378
ZIC4
Zic family member 4
chr4_+_120056938 0.610 NM_016599
MYOZ2
myozenin 2
chr19_-_9237625 0.609 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr12_+_72332625 0.606 NM_173353
TPH2
tryptophan hydroxylase 2
chr2_+_74011315 0.604 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chrX_+_123480131 0.596 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr11_+_6226797 0.589 NM_173525
C11orf42
chromosome 11 open reading frame 42
chr20_-_6034617 0.587 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr3_-_13057130 0.585


chr12_+_15125955 0.584 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr3_-_114790221 0.584 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chrX_+_70521627 0.583 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr6_+_123100860 0.581 FABP7
fatty acid binding protein 7, brain
chr11_-_6790187 0.579 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr16_+_69139466 0.576 NM_001199280
HAS3
hyaluronan synthase 3
chr1_-_114430168 0.572 NM_001010922
BCL2L15
BCL2-like 15
chr5_-_22212873 0.571 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_-_201081693 0.562 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr22_+_40322609 0.561 GRAP2
GRB2-related adaptor protein 2
chr3_+_185046682 0.554 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr3_-_121379757 0.549 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_74120132 0.547 ACTG2
actin, gamma 2, smooth muscle, enteric
chr1_+_84864214 0.547 NM_021233
DNASE2B
deoxyribonuclease II beta
chr16_-_31160828 0.543 PRSS36
protease, serine, 36
chr3_-_42917191 0.531 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_+_7623038 0.525 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr1_-_217250230 0.525 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr1_+_67632168 0.525 NM_144701
IL23R
interleukin 23 receptor
chr1_-_159284448 0.523 NM_001004467
OR10J3
olfactory receptor, family 10, subfamily J, member 3
chr1_+_155911479 0.522 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr18_+_43304091 0.517 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chrX_-_24665225 0.515 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_-_116693907 0.508 NM_000482
APOA4
apolipoprotein A-IV

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.56 3.54e-03 GO:0044459 plasma membrane part
1.88 1.90e-02 GO:0071944 cell periphery
2.93 2.95e-02 GO:0005887 integral to plasma membrane
2.88 3.54e-02 GO:0031226 intrinsic to plasma membrane
1.84 3.86e-02 GO:0005886 plasma membrane
2.33 4.95e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.47 1.59e-05 GO:0004872 receptor activity
2.84 4.38e-04 GO:0004871 signal transducer activity
2.84 4.38e-04 GO:0060089 molecular transducer activity
11.96 2.84e-02 GO:0004867 serine-type endopeptidase inhibitor activity
64.97 3.32e-02 GO:0031419 cobalamin binding