Motif ID: EWSR1-FLI1.p2

Z-value: 0.671


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EWSR1hg19_v1_chr22_+_29664216_296643390.506.0e-06Click!
FLI1hg19_v1_chr11_+_128564130_128564154-0.243.6e-02Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_1351570 5.034 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chrX_+_1401570 5.028 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chrX_+_585078 4.262 NM_000451
NM_006883
SHOX

short stature homeobox

chr4_-_57522059 4.225 HOPX
HOP homeobox
chr2_+_113816214 4.144 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr4_-_57522469 3.772 NM_001145459
NM_139211
HOPX

HOP homeobox

chr19_-_51472816 3.729 NM_002774
KLK6
kallikrein-related peptidase 6
chr20_+_43374487 3.391 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chrY_+_535078 2.997 NM_000451
NM_006883
SHOX

short stature homeobox

chr19_-_51487070 2.659 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr8_-_38008332 2.635 NM_000349
STAR
steroidogenic acute regulatory protein
chr2_-_21252786 2.553 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_79740059 2.548 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr5_-_142000899 2.531 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chrX_-_17879355 2.521 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr11_-_67141647 2.508 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr7_-_75419063 2.201 NM_006072
CCL26
chemokine (C-C motif) ligand 26
chr19_-_9237625 2.189 NM_001001958
OR7G3
olfactory receptor, family 7, subfamily G, member 3
chr10_-_90611675 1.993 NM_144590
ANKRD22
ankyrin repeat domain 22
chr5_+_156887026 1.989 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr2_+_113816684 1.890 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr2_-_96804173 1.796 NM_001002036
ASTL
astacin-like metallo-endopeptidase (M12 family)
chr16_-_2908105 1.645 NM_022119
PRSS22
protease, serine, 22
chr18_+_43405544 1.636 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr1_-_186417855 1.496 NM_022576
PDC
phosducin
chr6_+_36916038 1.478 NM_001199159
PI16
peptidase inhibitor 16
chr1_-_182030749 1.391 NM_001009992
ZNF648
zinc finger protein 648
chr3_-_58522873 1.363 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chrX_+_84498993 1.353 NM_021998
ZNF711
zinc finger protein 711
chr20_+_42187705 1.344 SGK2
serum/glucocorticoid regulated kinase 2
chr10_+_119302709 1.279


chr17_-_39092714 1.268 KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_153330329 1.256 NM_002965
S100A9
S100 calcium binding protein A9
chr7_-_99573637 1.255 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr15_-_79298001 1.250 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr1_-_223537400 1.221 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr19_-_51071279 1.214 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr3_-_164914448 1.205 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr16_+_69166522 1.192 CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr20_+_42187634 1.180 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_+_203444955 1.167 PRELP
proline/arginine-rich end leucine-rich repeat protein
chrX_-_49965003 1.165 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr5_-_101631965 1.128 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr3_-_192445344 1.126 NM_004113
FGF12
fibroblast growth factor 12
chr12_-_117175844 1.111 C12orf49
chromosome 12 open reading frame 49
chr1_+_167599503 1.105 RCSD1
RCSD domain containing 1
chr20_-_49308074 1.088


chr16_+_69166487 1.078 NM_032830
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr18_-_5630629 1.058 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr5_-_71803119 1.039 NM_152625
ZNF366
zinc finger protein 366
chr1_+_248020481 1.027 NM_015431
TRIM58
tripartite motif containing 58
chr19_-_47551881 1.015 NM_017854
TMEM160
transmembrane protein 160
chr13_+_113812967 1.011 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr1_+_202163117 1.011 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr1_-_11042093 1.008 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr4_-_16900028 1.008 LDB2
LIM domain binding 2
chr18_+_12947972 1.004 NM_001013437
NM_031216
SEH1L

SEH1-like (S. cerevisiae)

chr11_-_74442429 0.999 CHRDL2
chordin-like 2
chr1_+_248020607 0.995 TRIM58
tripartite motif containing 58
chr11_+_1074869 0.995 NM_002457
MUC2
mucin 2, oligomeric mucus/gel-forming
chr12_+_109273856 0.987 NM_001917
DAO
D-amino-acid oxidase
chr8_-_22550057 0.965 NM_001199881
EGR3
early growth response 3
chr11_+_71927818 0.929 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr18_+_12948004 0.921 SEH1L
SEH1-like (S. cerevisiae)
chr18_-_45935627 0.919 ZBTB7C
zinc finger and BTB domain containing 7C
chr3_+_115342302 0.898 GAP43
growth associated protein 43
chr2_-_128439359 0.894 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr11_-_74442185 0.885 NM_015424
CHRDL2
chordin-like 2
chr9_+_125796845 0.866 NM_005294
GPR21
G protein-coupled receptor 21
chr8_+_104152876 0.856 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr16_+_69140121 0.853 NM_138612
HAS3
hyaluronan synthase 3
chr12_-_108714438 0.850 NM_001142345
CMKLR1
chemokine-like receptor 1
chr3_-_50378238 0.849 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr12_+_66583029 0.848 IRAK3
interleukin-1 receptor-associated kinase 3
chr19_+_52901101 0.839 NM_032423
ZNF528
zinc finger protein 528
chr6_-_45983279 0.838 NM_016929
CLIC5
chloride intracellular channel 5
chr19_-_17958773 0.826 JAK3
Janus kinase 3
chr4_+_110736636 0.824 NM_018983
NM_032993
GAR1

GAR1 ribonucleoprotein homolog (yeast)

chr12_+_85673884 0.817 NM_006982
ALX1
ALX homeobox 1
chr19_-_4916814 0.808


chr19_-_17958814 0.806 NM_000215
JAK3
Janus kinase 3
chr1_-_31230594 0.793 LAPTM5
lysosomal protein transmembrane 5
chrX_+_48644961 0.791 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr19_-_42759279 0.788 NM_006494
ERF
Ets2 repressor factor
chr7_+_69064316 0.787 AUTS2
autism susceptibility candidate 2
chr12_+_56075329 0.784 NM_152637
METTL7B
methyltransferase like 7B
chr4_-_96470114 0.776 UNC5C
unc-5 homolog C (C. elegans)
chr3_-_192126837 0.771 NM_021032
FGF12
fibroblast growth factor 12
chr5_+_150040402 0.759 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr12_+_66583004 0.753 IRAK3
interleukin-1 receptor-associated kinase 3
chr9_-_124990706 0.750 NM_001242333
LHX6
LIM homeobox 6
chr1_-_31230673 0.740 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr5_+_175108463 0.739 NM_022304
HRH2
histamine receptor H2
chr19_-_18359009 0.735 NM_000923
PDE4C
phosphodiesterase 4C, cAMP-specific
chr17_+_18855477 0.735 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chrX_-_152711944 0.728 NM_080701
TREX2
three prime repair exonuclease 2
chr18_+_12948010 0.694 SEH1L
SEH1-like (S. cerevisiae)
chr4_-_16900348 0.693 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr18_+_9136742 0.686 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr9_+_115513050 0.684 NM_001012994
SNX30
sorting nexin family member 30
chr13_+_47127312 0.681 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chrX_-_109561427 0.675 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_225840660 0.670 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr12_+_93771607 0.667 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr22_+_39966757 0.662 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr5_+_69345349 0.654 NM_000344
NM_022874
NM_017411
NM_022875
NM_022876
NM_022877
SMN1

SMN2



survival of motor neuron 1, telomeric

survival of motor neuron 2, centromeric



chr1_-_238054221 0.646 NM_021186
ZP4
zona pellucida glycoprotein 4
chrX_-_109561314 0.644 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr4_+_110736911 0.643 GAR1
GAR1 ribonucleoprotein homolog (yeast)
chrX_-_102983551 0.642 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chr11_+_63974190 0.638 FERMT3
fermitin family member 3
chr19_-_48823331 0.632 NM_144577
CCDC114
coiled-coil domain containing 114
chr11_-_31832592 0.632 PAX6
paired box 6
chr7_+_138482696 0.615 NM_001085429
TMEM213
transmembrane protein 213
chr1_+_157963062 0.615 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr3_+_170075449 0.614 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr3_+_170075521 0.614 SKIL
SKI-like oncogene
chr1_+_167599329 0.611 NM_052862
RCSD1
RCSD domain containing 1
chr19_+_1207129 0.602 EFNA2
ephrin-A2
chr6_+_116937641 0.602 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr13_+_47127295 0.594 NM_001164211
NM_001164213
NM_015116
LRCH1


leucine-rich repeats and calponin homology (CH) domain containing 1


chr8_-_29206321 0.588 NM_057158
DUSP4
dual specificity phosphatase 4
chr12_+_10331556 0.587 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr13_+_47127383 0.587 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr9_-_124989755 0.580 NM_001242334
LHX6
LIM homeobox 6
chr11_+_2323236 0.575 NM_139022
TSPAN32
tetraspanin 32
chr7_+_69063768 0.575 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr19_-_42759151 0.561 ERF
Ets2 repressor factor
chr17_+_635656 0.559 NM_024792
FAM57A
family with sequence similarity 57, member A
chr11_+_101980736 0.558 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr15_+_84115979 0.548 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chrX_-_109561298 0.542 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr13_+_47127481 0.534 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr6_+_139013551 0.533 FLJ46906
uncharacterized LOC441172
chr1_-_157670280 0.530 NM_052939
FCRL3
Fc receptor-like 3
chr5_+_152870083 0.520 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr3_+_170075494 0.518 SKIL
SKI-like oncogene
chr12_+_2904289 0.517 FKBP4
FK506 binding protein 4, 59kDa
chr5_+_86563819 0.502


chr12_+_106976684 0.501 NM_213594
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr12_-_49365545 0.495 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr12_+_66582914 0.493 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr2_+_182756665 0.492 SSFA2
sperm specific antigen 2
chr15_-_88799961 0.485 NM_001007156
NM_001012338
NM_001243101
NM_002530
NTRK3



neurotrophic tyrosine kinase, receptor, type 3



chr7_-_102985068 0.478 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr4_+_84457256 0.475 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_-_93257950 0.474 NM_005665
EVI5
ecotropic viral integration site 5
chr1_-_68697997 0.472 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr8_-_145559831 0.469 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr8_-_93107881 0.460 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr9_-_104357202 0.460 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr13_-_28543290 0.459 NM_001265
CDX2
caudal type homeobox 2
chr17_+_27573874 0.454 NM_005208
CRYBA1
crystallin, beta A1
chr11_-_31832758 0.449 PAX6
paired box 6
chr19_-_39826625 0.448 GMFG
glia maturation factor, gamma
chrX_+_198060 0.445 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr4_-_44450823 0.445 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr1_+_186798031 0.440 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr12_-_81331487 0.439 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr6_+_43738177 0.438 VEGFA
vascular endothelial growth factor A
chr19_-_33716609 0.435 NM_019849
SLC7A10
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
chr20_+_10199455 0.434 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr4_-_16900256 0.434 LDB2
LIM domain binding 2
chr11_-_67407024 0.431 NM_005995
TBX10
T-box 10
chr11_-_123065988 0.430 NM_024769
CLMP
CXADR-like membrane protein
chr1_+_203444882 0.428 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr5_+_86563594 0.426 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chrY_+_148060 0.425 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr9_-_107361693 0.423 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr17_-_42297037 0.420 NM_001076684
NM_014233
UBTF

upstream binding transcription factor, RNA polymerase I

chr5_-_137089990 0.420 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr1_+_29063443 0.419 NM_001172828
YTHDF2
YTH domain family, member 2
chr7_+_128355425 0.410 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr8_-_93107643 0.408 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_150999412 0.404 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr1_+_162602308 0.401 DDR2
discoidin domain receptor tyrosine kinase 2
chr16_-_47007567 0.396 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr17_+_48133357 0.395 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chrX_+_152599544 0.386 NM_001080485
ZNF275
zinc finger protein 275
chrX_-_111326003 0.386 NM_012471
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chr17_+_48133331 0.384 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr11_+_17757494 0.382 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr5_-_137090033 0.380 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr11_-_64410785 0.379 NM_138734
NRXN2
neurexin 2
chr10_-_125651494 0.377 NM_198148
CPXM2
carboxypeptidase X (M14 family), member 2
chr17_+_38137088 0.371 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr1_+_109234908 0.370 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr12_+_2904101 0.366 NM_002014
FKBP4
FK506 binding protein 4, 59kDa
chr17_+_38137081 0.362 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr12_-_9760481 0.360 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr11_-_2323066 0.354 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr4_+_84457390 0.353 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr6_+_31638727 0.352 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chrX_-_78623006 0.351 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr19_-_16284285 0.336 NM_054113
CIB3
calcium and integrin binding family member 3
chr2_+_182756468 0.333 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr17_-_63052884 0.330 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr1_-_48462561 0.330 NM_001194986
LOC388630
UPF0632 protein A
chr1_+_162602198 0.327 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr9_-_107665959 0.327 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.04 2.49e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.68 3.53e-02 GO:0030247 polysaccharide binding
9.22 4.24e-02 GO:0008236 serine-type peptidase activity
9.05 4.53e-02 GO:0017171 serine hydrolase activity