Motif ID: ETS1,2.p2

Z-value: 0.993


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ETS1hg19_v1_chr11_-_128391888_128392038-0.404.4e-04Click!
ETS2hg19_v1_chr21_+_40177754_401778400.351.8e-03Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_15918635 11.291 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chrX_-_130964633 8.364 LOC286467
family with sequence similarity 195, member A pseudogene
chr13_+_31287614 6.786 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_-_31230594 6.582 LAPTM5
lysosomal protein transmembrane 5
chr1_+_18807423 5.835 NM_152375
KLHDC7A
kelch domain containing 7A
chr19_-_17516383 5.107 NM_004335
BST2
bone marrow stromal cell antigen 2
chr1_-_31230673 4.937 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr6_-_11382501 4.914 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr19_+_6772705 4.913 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr14_-_23284617 4.743 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr19_-_56632600 4.513 ZNF787
zinc finger protein 787
chr12_+_52416615 4.449 NM_001202233
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr4_-_39033981 4.113 NM_024943
TMEM156
transmembrane protein 156
chr11_+_44785975 4.087 NM_130783
TSPAN18
tetraspanin 18
chr4_-_74964836 3.996 CXCL2
chemokine (C-X-C motif) ligand 2
chr10_+_124030820 3.988 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr19_+_6772801 3.747


chr19_-_56632644 3.727 NM_001002836
ZNF787
zinc finger protein 787
chr5_+_159656436 3.715 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr10_+_114154522 3.709 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_49318663 3.684 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr15_-_74500394 3.199 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr7_-_99277518 2.964 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr2_+_85980600 2.952 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr19_+_11998609 2.929 NM_021915
ZNF69
zinc finger protein 69
chr11_+_1861431 2.850 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr19_+_44556163 2.844 NM_013361
ZNF223
zinc finger protein 223
chr4_-_189026401 2.793 NM_173553
TRIML2
tripartite motif family-like 2
chr6_+_126240369 2.738 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr10_-_5060191 2.609 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr6_-_7389941 2.561 NM_001170692
NM_001170693
NM_205864
CAGE1


cancer antigen 1


chr19_-_39402797 2.524 NM_001243212
LOC643669
uncharacterized LOC643669
chr15_-_74501309 2.458 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chr6_+_75994713 2.421 LOC100506804
uncharacterized LOC100506804
chr19_+_1776117 2.368


chr10_+_114135965 2.366 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_28304151 2.358 NM_001243241
NM_001243242
NM_001243244
NM_030899
ZNF323



zinc finger protein 323



chr19_+_16435734 2.339 KLF2
Kruppel-like factor 2 (lung)
chr19_-_50083813 2.336 NOSIP
nitric oxide synthase interacting protein
chr20_+_58630965 2.312 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr12_+_104682495 2.307 TXNRD1
thioredoxin reductase 1
chr4_-_70626429 2.304 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr19_-_50083791 2.299 NM_015953
NOSIP
nitric oxide synthase interacting protein
chrX_-_107019001 2.277 NM_198057
TSC22D3
TSC22 domain family, member 3
chr10_+_123923104 2.238 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr10_+_5238756 2.203 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr1_+_212738675 2.189 NM_001030287
ATF3
activating transcription factor 3
chr5_-_126409171 2.157 NM_001164478
NM_001164479
C5orf63

chromosome 5 open reading frame 63

chr20_+_42839599 2.143 LOC100505783
uncharacterized LOC100505783
chr19_+_42387249 2.139 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr14_+_105953531 2.135 CRIP1
cysteine-rich protein 1 (intestinal)
chr10_+_5136589 2.135 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_-_224467049 2.129 SCG2
secretogranin II
chr16_+_2880172 2.122 NM_145252
ZG16B
zymogen granule protein 16 homolog B (rat)
chr10_+_5136613 2.052 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_6086412 2.035 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr2_-_113542970 2.032 NM_000575
IL1A
interleukin 1, alpha
chr10_+_5136556 2.032 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr12_-_123201319 2.017 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr15_-_72490109 2.008 NM_001012642
GRAMD2
GRAM domain containing 2
chr19_+_55897298 1.973 NM_000991
NM_001136134
NM_001136135
NM_001136136
NM_001136137
RPL28




ribosomal protein L28




chr2_-_188419185 1.967 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr19_+_44669214 1.935 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr1_-_232651227 1.924 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr11_+_2466171 1.912 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr9_-_133814422 1.904 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr9_-_133813988 1.904 FIBCD1
fibrinogen C domain containing 1
chr11_+_36397534 1.897 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr8_-_9008138 1.888 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr2_+_109745996 1.875 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr6_-_28411228 1.874 NM_001012455
ZSCAN23
zinc finger and SCAN domain containing 23
chr3_-_171528227 1.871 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr10_+_99344421 1.859 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr19_+_56186426 1.858 NM_001130072
NM_013333
EPN1

epsin 1

chr4_-_185747051 1.847 ACSL1
acyl-CoA synthetase long-chain family member 1
chr10_+_91061705 1.836 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr22_+_50354139 1.831 NM_001001852
PIM3
pim-3 oncogene
chr12_-_91576805 1.828 NM_001920
DCN
decorin
chr19_+_13261272 1.818 NM_004907
IER2
immediate early response 2
chr11_+_2920910 1.817 NM_183233
SLC22A18
solute carrier family 22, member 18
chr17_+_77751929 1.809 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr11_+_36317724 1.803 NM_001160167
PRR5L
proline rich 5 like
chr14_-_23284565 1.793 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr20_-_61002588 1.785 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr1_-_161039413 1.782 ARHGAP30
Rho GTPase activating protein 30
chr14_-_23285011 1.781 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr19_-_44439410 1.779 NM_003425
ZNF45
zinc finger protein 45
chr1_+_206643585 1.778 NM_001193321
NM_001193322
NM_014002
IKBKE


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon


chr19_-_55791446 1.766 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr19_+_2977480 1.763 NM_001143986
NM_024760
TLE6

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

chr17_-_80275370 1.713 NM_006137
CD7
CD7 molecule
chr6_+_31895401 1.712 C2
complement component 2
chrX_-_107018889 1.710 TSC22D3
TSC22 domain family, member 3
chr19_+_59070557 1.695 LOC100131691
uncharacterized LOC100131691
chr11_-_417324 1.685 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr5_+_31799030 1.685 NM_178140
PDZD2
PDZ domain containing 2
chr2_-_188419049 1.682 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_224467142 1.680 NM_003469
SCG2
secretogranin II
chr2_-_224467095 1.675 SCG2
secretogranin II
chr1_+_6086369 1.675 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chrX_-_15620191 1.667 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr5_+_137801178 1.667 NM_001964
EGR1
early growth response 1
chr22_-_18923654 1.657 PRODH
proline dehydrogenase (oxidase) 1
chr19_+_48248798 1.654 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr6_-_28303910 1.653 NM_001135216
NM_001243243
ZNF323

zinc finger protein 323

chr19_-_55791428 1.646 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr3_-_187454247 1.643 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr19_+_49977465 1.639 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chr19_+_48248792 1.622 NM_015710
GLTSCR2
glioma tumor suppressor candidate region gene 2
chr19_-_55791490 1.619 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr19_+_42363987 1.614 NM_001022
RPS19
ribosomal protein S19
chr10_+_112257624 1.608 NM_004419
DUSP5
dual specificity phosphatase 5
chr19_+_47759730 1.604 NM_015603
CCDC9
coiled-coil domain containing 9
chr19_+_42387307 1.597 ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr19_+_47759802 1.586 CCDC9
coiled-coil domain containing 9
chr19_-_56092184 1.584 NM_152600
ZNF579
zinc finger protein 579
chr8_-_124665165 1.580 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr16_-_67260900 1.579 NM_001004055
LRRC29
leucine rich repeat containing 29
chr11_-_3147837 1.564 OSBPL5
oxysterol binding protein-like 5
chr12_+_53440809 1.563 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_206643786 1.553 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr3_-_196065191 1.548 TM4SF19
transmembrane 4 L six family member 19
chr17_-_39093671 1.547 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_162346579 1.544 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr2_+_71162995 1.543 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr7_-_95225802 1.543 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr17_-_1548992 1.542 NM_003693
NM_145350
NM_145352
SCARF1


scavenger receptor class F, member 1


chr17_+_25958217 1.533 LGALS9
lectin, galactoside-binding, soluble, 9
chr7_-_151574209 1.533 NM_016203
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr11_+_64107687 1.532 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr12_-_110486275 1.530 C12orf76
chromosome 12 open reading frame 76
chr20_-_42839295 1.529 C20orf111
chromosome 20 open reading frame 111
chr20_-_42839423 1.518 NM_016470
C20orf111
chromosome 20 open reading frame 111
chr2_-_230135954 1.509 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr22_+_21369441 1.498 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr19_+_49977817 1.497 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr11_+_102188180 1.495 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr5_-_95748688 1.494 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr5_+_52095929 1.487 PELO
pelota homolog (Drosophila)
chr19_-_49140569 1.486 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr18_+_55711746 1.480 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr22_+_21321446 1.474 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr11_+_48002063 1.473 NM_001098503
NM_002843
PTPRJ

protein tyrosine phosphatase, receptor type, J

chr19_-_56739658 1.470 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr19_-_55791727 1.467 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr15_+_66995414 1.464 SMAD6
SMAD family member 6
chr14_+_103592663 1.455 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chrX_-_15402469 1.437 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr4_+_189060597 1.420 NM_178556
TRIML1
tripartite motif family-like 1
chr4_-_82393025 1.411 NM_152545
RASGEF1B
RasGEF domain family, member 1B
chr14_+_75745480 1.410 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_99224868 1.396 NM_001008215
COA5
cytochrome C oxidase assembly factor 5
chr1_+_37940129 1.396 ZC3H12A
zinc finger CCCH-type containing 12A
chr17_-_1553099 1.395 NM_031430
RILP
Rab interacting lysosomal protein
chr8_-_133772808 1.392 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr12_-_49319211 1.388 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chrX_+_43515531 1.382 MAOA
monoamine oxidase A
chr16_+_30108398 1.379


chr15_+_67000929 1.371 NM_001142861
SMAD6
SMAD family member 6
chr18_-_47792773 1.369 NM_145020
CCDC11
coiled-coil domain containing 11
chr19_+_46144904 1.362 NM_001242348
LOC100287177
uncharacterized LOC100287177
chr11_+_47270433 1.350 NM_001130102
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr6_-_133078894 1.348 NM_001242350
NM_004665
VNN2

vanin 2

chr3_-_196065243 1.337 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr10_+_114136014 1.327 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_123187842 1.324 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr19_+_42364322 1.323 RPS19
ribosomal protein S19
chr3_-_185270258 1.320 NM_139248
LIPH
lipase, member H
chr9_+_130854127 1.319 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr2_+_119699744 1.317 NM_006770
MARCO
macrophage receptor with collagenous structure
chrX_+_18709044 1.309 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr1_+_3388170 1.307 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr8_+_144356708 1.306 GLI4
GLI family zinc finger 4
chr9_-_88969256 1.304 ZCCHC6
zinc finger, CCHC domain containing 6
chr18_+_51795848 1.299 NM_007195
POLI
polymerase (DNA directed) iota
chr19_+_42364262 1.294 RPS19
ribosomal protein S19
chr5_-_131826426 1.287 NM_002198
IRF1
interferon regulatory factor 1
chr4_-_82392971 1.263 RASGEF1B
RasGEF domain family, member 1B
chr18_+_55862577 1.258 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_34654010 1.246 NM_001206616
EHF
ets homologous factor
chr1_-_47655723 1.245 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr19_+_55897302 1.244 RPL28
ribosomal protein L28
chr12_-_10573041 1.239 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr5_+_179220985 1.238 NM_145867
LTC4S
leukotriene C4 synthase
chr2_+_110371887 1.230 NM_023016
ANKRD57
ankyrin repeat domain 57
chr14_-_103995336 1.227


chr11_-_67210915 1.225 CORO1B
coronin, actin binding protein, 1B
chr9_+_131185129 1.219 CERCAM
cerebral endothelial cell adhesion molecule
chr1_+_196621007 1.218 NM_000186
NM_001014975
CFH

complement factor H

chr1_+_6086072 1.213 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr11_+_20044362 1.210 NAV2
neuron navigator 2
chr17_+_25958192 1.210 LGALS9
lectin, galactoside-binding, soluble, 9
chr11_+_48002120 1.209 PTPRJ
protein tyrosine phosphatase, receptor type, J
chr18_+_55711890 1.190 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_+_56186610 1.184 EPN1
epsin 1
chr15_-_83419125 1.183


chr4_+_41614725 1.182 LIMCH1
LIM and calponin homology domains 1
chr9_-_88969323 1.181 NM_001185059
NM_001185074
NM_024617
ZCCHC6


zinc finger, CCHC domain containing 6


chr12_+_56546203 1.177 NM_001199629
NM_002475
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr9_-_89562103 1.176 NM_002048
GAS1
growth arrest-specific 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.59 1.42e-02 GO:0006629 lipid metabolic process
4.11 1.47e-02 GO:0032787 monocarboxylic acid metabolic process
2.68 3.10e-02 GO:0048584 positive regulation of response to stimulus
2.82 3.79e-02 GO:0019752 carboxylic acid metabolic process
2.82 3.79e-02 GO:0043436 oxoacid metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
69.59 9.17e-04 GO:0047023 androsterone dehydrogenase activity