Motif ID: ESR1.p2

Z-value: 1.223


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESR1hg19_v1_chr6_+_152126807_152126839-0.447.1e-05Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_325867 18.735 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr4_-_57976550 13.745 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr19_+_15218141 13.635 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr16_+_82660573 12.437 CDH13
cadherin 13, H-cadherin (heart)
chr5_-_1112106 11.792 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr5_-_157002739 11.519 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr12_-_133532847 10.137 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr14_-_21493910 9.545 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chrX_-_48693934 9.364 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr14_-_21493858 8.350 NDRG2
NDRG family member 2
chr20_-_62130390 7.788 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chrX_-_51239295 7.755 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr5_-_157002705 7.410


chr19_+_56879687 7.104 ZNF542
zinc finger protein 542
chr12_-_95044205 6.353 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr9_-_86153048 5.984 NM_001244959
NM_174938
FRMD3

FERM domain containing 3

chr16_+_82660390 5.784 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr1_-_156265395 5.441 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr1_+_215256559 5.381 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr19_+_52873169 5.314 NM_001145434
ZNF880
zinc finger protein 880
chr6_-_153452383 5.275 NM_012419
RGS17
regulator of G-protein signaling 17
chr19_+_4304590 5.199 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr1_-_21058701 4.980 SH2D5
SH2 domain containing 5
chr17_-_19770988 4.891 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr17_+_74380943 4.784 SPHK1
sphingosine kinase 1
chr17_-_43045612 4.612 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr9_+_4490193 4.601 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr17_+_74381419 4.522 SPHK1
sphingosine kinase 1
chr17_+_74381186 4.464 NM_001142602
SPHK1
sphingosine kinase 1
chr20_-_25038501 4.442 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chr17_+_74380676 4.245 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr17_+_19437140 4.240 NM_018242
SLC47A1
solute carrier family 47, member 1
chr2_-_233792825 4.130 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr10_-_62703822 3.983 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr15_+_68908878 3.954 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr18_+_9708322 3.895 RAB31
RAB31, member RAS oncogene family
chr1_-_156265457 3.884 C1orf85
chromosome 1 open reading frame 85
chr14_+_105992930 3.854 NM_025268
TMEM121
transmembrane protein 121
chr5_-_137475076 3.848 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr20_+_361938 3.770 TRIB3
tribbles homolog 3 (Drosophila)
chr4_+_156587861 3.757 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr4_-_101111606 3.753 NM_145244
DDIT4L
DNA-damage-inducible transcript 4-like
chr17_-_33700619 3.740 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr9_+_33750463 3.657 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr14_+_65007418 3.634 HSPA2
heat shock 70kDa protein 2
chr19_-_1513187 3.633 NM_213604
ADAMTSL5
ADAMTS-like 5
chr8_-_61193882 3.541 NM_004056
CA8
carbonic anhydrase VIII
chr18_+_9708187 3.533 NM_006868
RAB31
RAB31, member RAS oncogene family
chr4_-_77819001 3.523 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr11_-_74022609 3.406 NM_182904
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr11_+_64067862 3.406 NM_001039496
C11orf20
chromosome 11 open reading frame 20
chr8_+_32405727 3.342 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr11_+_60609428 3.339 NM_024098
CCDC86
coiled-coil domain containing 86
chr3_-_53880403 3.276 NM_018397
CHDH
choline dehydrogenase
chr10_-_30348433 3.257 NM_020848
KIAA1462
KIAA1462
chr15_+_68871285 3.245 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr9_-_6645564 3.224 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr15_-_75248925 3.175 RPP25
ribonuclease P/MRP 25kDa subunit
chr19_-_37958338 3.152 NM_152484
ZNF569
zinc finger protein 569
chr4_+_156588811 3.145 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr16_+_55515468 3.099 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr4_-_57976516 3.095 IGFBP7
insulin-like growth factor binding protein 7
chr6_+_33422319 3.087 NM_152735
ZBTB9
zinc finger and BTB domain containing 9
chr9_+_139972195 3.072 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr2_+_132285469 3.035 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr3_-_184870627 3.033 C3orf70
chromosome 3 open reading frame 70
chr13_-_20767036 3.003 GJB2
gap junction protein, beta 2, 26kDa
chr5_-_131347518 2.985 NM_001205248
NM_001205251
NM_001205250
ACSL6


acyl-CoA synthetase long-chain family member 6


chr19_-_19932512 2.979 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chr19_-_1512997 2.970 ADAMTSL5
ADAMTS-like 5
chr12_+_66218879 2.948 HMGA2
high mobility group AT-hook 2
chr13_-_20767100 2.945 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr7_+_105517209 2.933 CDHR3
cadherin-related family member 3
chr4_-_11430502 2.915 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr20_+_44098392 2.899 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr19_-_18717467 2.840 CRLF1
cytokine receptor-like factor 1
chr14_+_65007163 2.811 NM_021979
HSPA2
heat shock 70kDa protein 2
chr19_-_18717577 2.809 CRLF1
cytokine receptor-like factor 1
chr2_-_1748317 2.807 PXDN
peroxidasin homolog (Drosophila)
chr18_+_9708269 2.749 RAB31
RAB31, member RAS oncogene family
chr18_+_9708299 2.690 RAB31
RAB31, member RAS oncogene family
chr17_-_7297826 2.686 PLSCR3
phospholipid scramblase 3
chr19_-_18717631 2.669 NM_004750
CRLF1
cytokine receptor-like factor 1
chr6_-_47277354 2.624 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_16083132 2.593 FBLIM1
filamin binding LIM protein 1
chr10_+_102732285 2.553 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr10_+_102758072 2.528 LZTS2
leucine zipper, putative tumor suppressor 2
chr19_+_7580987 2.457 NM_018083
ZNF358
zinc finger protein 358
chr2_-_224903933 2.453 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr12_-_71031174 2.452 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_+_98881277 2.447 NM_002380
NM_030583
MATN2

matrilin 2

chr1_-_94702916 2.443 ARHGAP29
Rho GTPase activating protein 29
chr2_-_1748240 2.407 PXDN
peroxidasin homolog (Drosophila)
chr5_+_68800003 2.374 NM_001205255
OCLN
occludin
chr1_-_24513737 2.369 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr19_-_51456159 2.368 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr2_-_1748213 2.344 PXDN
peroxidasin homolog (Drosophila)
chr14_+_90528107 2.302 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr20_-_1165116 2.290 NM_018354
TMEM74B
transmembrane protein 74B
chr2_+_101436491 2.289 NM_002518
NPAS2
neuronal PAS domain protein 2
chr11_-_70963619 2.282 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr16_+_67686813 2.272 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr21_-_46962281 2.247 NM_001205206
NM_194255
SLC19A1

solute carrier family 19 (folate transporter), member 1

chr1_-_201476241 2.246 CSRP1
cysteine and glycine-rich protein 1
chr1_+_162531229 2.227 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr2_-_1748285 2.221 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_-_201476218 2.213 CSRP1
cysteine and glycine-rich protein 1
chr1_-_94703252 2.201 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr16_+_222845 2.158 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr13_+_51796363 2.156 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr15_+_101420004 2.147 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr15_+_101420032 2.115 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr10_+_122216465 2.109 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr1_-_201475966 2.105 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr2_-_216300770 2.104 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr5_-_131347249 2.103 NM_001009185
NM_001205247
NM_015256
ACSL6


acyl-CoA synthetase long-chain family member 6


chr6_-_47277246 2.103 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr16_-_75285383 2.100 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr10_+_64133915 2.099 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr1_-_153433104 2.097 NM_002963
S100A7
S100 calcium binding protein A7
chr1_+_162531349 2.094 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr10_-_62761197 2.081 RHOBTB1
Rho-related BTB domain containing 1
chr20_+_62492565 2.080 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr10_+_12391471 2.060 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr4_+_81187741 2.046 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr19_+_17905935 2.018 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr6_+_160769365 1.995 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr17_-_78450247 1.991 NM_002522
NPTX1
neuronal pentraxin I
chr16_+_30907927 1.988 NM_001142544
NM_001330
CTF1

cardiotrophin 1

chr19_+_17905907 1.984 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr21_+_46825291 1.979


chr20_-_56285576 1.958 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr3_-_184870727 1.936 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr8_+_27182995 1.928 NM_173176
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr4_-_83483099 1.909 NM_001080506
TMEM150C
transmembrane protein 150C
chr19_-_7553867 1.909 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr10_+_75670861 1.905 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr19_+_639878 1.899 NM_020637
FGF22
fibroblast growth factor 22
chr19_+_20011700 1.889 NM_031218
ZNF93
zinc finger protein 93
chr14_-_23388359 1.885 RBM23
RNA binding motif protein 23
chr15_+_84116172 1.884 SH3GL3
SH3-domain GRB2-like 3
chr19_-_18548971 1.883 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr5_-_168727715 1.876 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr20_-_61569227 1.860 DIDO1
death inducer-obliterator 1
chr20_-_62284701 1.843 NM_015894
STMN3
stathmin-like 3
chr1_+_36038970 1.828 NM_178548
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr19_+_16178170 1.825 NM_001145160
TPM4
tropomyosin 4
chr4_+_4861371 1.815 NM_002448
MSX1
msh homeobox 1
chr1_-_201476248 1.799 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr14_-_23388380 1.790 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr17_+_45331154 1.784 NM_000212
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr5_+_132149022 1.764 NM_175873
ANKRD43
ankyrin repeat domain 43
chr19_-_2721337 1.760 NM_145173
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr13_+_76210449 1.755 LMO7
LIM domain 7
chr9_+_129376721 1.753 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr9_+_131644368 1.749 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr9_+_131644780 1.748 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr12_+_65218441 1.731 TBC1D30
TBC1 domain family, member 30
chr8_-_145018904 1.730 NM_201381
PLEC
plectin
chr3_-_13114547 1.725 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr18_+_29598787 1.703 RNF125
ring finger protein 125
chr1_+_207627614 1.701 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr1_+_107682628 1.688 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr9_+_131644427 1.680 LRRC8A
leucine rich repeat containing 8 family, member A
chr12_+_65218351 1.678 NM_015279
TBC1D30
TBC1 domain family, member 30
chr19_-_17414083 1.673 NM_024527
ABHD8
abhydrolase domain containing 8
chr8_-_25315791 1.666 KCTD9
potassium channel tetramerisation domain containing 9
chr20_-_62711160 1.664 NM_001039467
RGS19
regulator of G-protein signaling 19
chr14_-_69445772 1.656 ACTN1
actinin, alpha 1
chr20_-_57089845 1.640 NM_153360
APCDD1L
adenomatosis polyposis coli down-regulated 1-like
chr3_-_52090090 1.637 NM_001947
DUSP7
dual specificity phosphatase 7
chr20_+_23331372 1.586 NM_013248
NXT1
NTF2-like export factor 1
chr19_-_7990974 1.579 NM_206833
CTXN1
cortexin 1
chr11_-_67141647 1.576 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr9_+_5450455 1.567 NM_014143
CD274
CD274 molecule
chr20_-_3219835 1.531 NM_001174089
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr6_-_170599568 1.529 NM_005618
DLL1
delta-like 1 (Drosophila)
chr17_-_5095131 1.525 NM_032530
ZNF594
zinc finger protein 594
chr3_-_24536176 1.521 NM_000461
NM_001128176
NM_001128177
NM_001252634
THRB



thyroid hormone receptor, beta



chr22_-_37915209 1.520 NM_014550
CARD10
caspase recruitment domain family, member 10
chr12_+_132413776 1.492 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr1_+_159750756 1.484 NM_017823
DUSP23
dual specificity phosphatase 23
chr5_+_90676131 1.484 LOC100129716
uncharacterized LOC100129716
chr1_-_146696896 1.477 FMO5
flavin containing monooxygenase 5
chr6_-_3157696 1.474 NM_001069
TUBB2A
tubulin, beta 2A class IIa
chr1_-_51810693 1.474 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr11_+_64126616 1.473 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4

chr1_+_150122095 1.467 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr10_-_105420850 1.467


chr9_-_74383301 1.460 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr6_+_29691203 1.447 HLA-F
major histocompatibility complex, class I, F
chr4_+_1795004 1.443 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr8_-_25315746 1.438 KCTD9
potassium channel tetramerisation domain containing 9
chr10_+_81892497 1.436 PLAC9
placenta-specific 9
chr1_+_33546700 1.435 NM_052998
ADC
arginine decarboxylase
chr16_+_8768403 1.433 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr16_+_29912146 1.432 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr19_+_8274179 1.427 NM_024552
CERS4
ceramide synthase 4
chr19_+_10527448 1.416 NM_001243121
PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_+_145582208 1.413 NM_001253816
NM_001253815
GPR172A

G protein-coupled receptor 172A


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.64 3.89e-03 GO:0023052 signaling
1.61 3.20e-02 GO:0007165 signal transduction
4.87 3.48e-02 GO:0001525 angiogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.29 4.35e-03 GO:0044421 extracellular region part
2.47 7.44e-03 GO:0005615 extracellular space
4.62 2.60e-02 GO:0005912 adherens junction
1.69 4.57e-02 GO:0044459 plasma membrane part
1.45 4.73e-02 GO:0005886 plasma membrane

Nothing significant found in function category.