Motif ID: EP300.p2

Z-value: 1.163


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EP300hg19_v1_chr22_+_41487787_41487794-0.142.4e-01Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_95007139 8.679 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr3_+_111578640 4.825 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_+_111578528 4.469 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr15_-_74726258 4.333 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr3_+_111578606 4.159 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr20_-_22564893 4.145 FOXA2
forkhead box A2
chrX_+_55478537 3.783 NM_014061
MAGEH1
melanoma antigen family H, 1
chr9_+_33750463 3.391 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr19_-_1401474 3.345 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr11_-_128391888 3.165 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr10_-_116164514 3.061 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr3_+_111578136 3.003 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr20_-_33460558 2.986 NM_178026
GGT7
gamma-glutamyltransferase 7
chr4_+_84457256 2.942 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr3_+_111578026 2.874 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr9_-_117880411 2.855 NM_002160
TNC
tenascin C
chr19_+_36347809 2.852 NM_032123
NM_199179
NM_199180
KIRREL2


kin of IRRE like 2 (Drosophila)


chr6_+_7726268 2.834 BMP6
bone morphogenetic protein 6
chr2_+_182321933 2.827 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr17_+_54671059 2.825 NM_005450
NOG
noggin
chr17_+_38119225 2.795 NM_178171
GSDMA
gasdermin A
chr9_-_86153048 2.763 NM_001244959
NM_174938
FRMD3

FERM domain containing 3

chr6_-_47009992 2.721 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr1_+_215256559 2.659 NM_001017425
NM_014217
KCNK2

potassium channel, subfamily K, member 2

chr6_+_144471631 2.631 NM_003764
STX11
syntaxin 11
chr14_-_61190458 2.600 NM_017420
SIX4
SIX homeobox 4
chr10_-_92617417 2.555 HTR7
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
chr11_+_15136483 2.553 NM_001042536
INSC
inscuteable homolog (Drosophila)
chr2_-_233877920 2.491 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr6_+_151561653 2.469 AKAP12
A kinase (PRKA) anchor protein 12
chr16_+_69373414 2.451 NM_001199434
NM_016101
NIP7

nuclear import 7 homolog (S. cerevisiae)

chr11_+_94277005 2.450 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr15_-_101459410 2.441


chr11_-_68039446 2.387 NM_022338
C11orf24
chromosome 11 open reading frame 24
chr6_-_86352696 2.373 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr7_-_5553401 2.365 FBXL18
F-box and leucine-rich repeat protein 18
chr11_-_68039327 2.344 C11orf24
chromosome 11 open reading frame 24
chr20_-_30311693 2.341 BCL2L1
BCL2-like 1
chr14_-_69446038 2.331 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr1_-_20812727 2.324 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr4_-_186456580 2.285 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr12_-_49365545 2.251 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr16_+_226678 2.247 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr6_-_86352635 2.236 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr6_-_86352564 2.234 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr12_-_54813002 2.227 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr7_+_128470462 2.225 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr6_-_86352656 2.220 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr5_+_52776479 2.215 FST
follistatin
chr19_+_16187315 2.215 TPM4
tropomyosin 4
chr22_+_42470247 2.208 NM_001002034
FAM109B
family with sequence similarity 109, member B
chr1_+_24117645 2.196 NM_007260
LYPLA2
lysophospholipase II
chr2_+_182321618 2.141 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_+_48828820 2.136 EMP3
epithelial membrane protein 3
chr16_+_222845 2.125 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr14_-_69446008 2.089 ACTN1
actinin, alpha 1
chr4_+_184426147 2.088 NM_001564
ING2
inhibitor of growth family, member 2
chr2_-_233877901 2.083 NGEF
neuronal guanine nucleotide exchange factor
chr14_-_69445989 2.078 ACTN1
actinin, alpha 1
chr12_-_48152180 2.074 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr1_+_229761988 2.063 URB2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr2_+_37571752 2.053 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr4_-_11430502 2.052 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr14_-_69445978 2.036 ACTN1
actinin, alpha 1
chr12_-_58159386 2.034 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr12_-_54812936 2.023 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr9_+_35792405 2.022 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr14_-_69445948 1.996 ACTN1
actinin, alpha 1
chr1_+_229761962 1.988 NM_014777
URB2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr14_-_69445974 1.955 ACTN1
actinin, alpha 1
chr3_-_50649110 1.947 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr16_+_2653350 1.944 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr2_+_182322265 1.944 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr5_+_82767492 1.941 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr13_+_51796363 1.932 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr4_-_74853819 1.929 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr6_-_86352650 1.922 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr9_+_112403067 1.915 NM_001037293
PALM2
paralemmin 2
chr6_-_47277646 1.909 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_107682628 1.903 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr5_-_1112106 1.901 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr7_-_108096693 1.896 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr1_-_155939051 1.885 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr9_-_132404277 1.869 NM_001202403
NM_017873
NM_177999
ASB6


ankyrin repeat and SOCS box containing 6


chr3_+_71803200 1.868 NM_018971
GPR27
G protein-coupled receptor 27
chr16_+_83986826 1.857 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr10_-_99161013 1.857 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr3_-_50649080 1.856 CISH
cytokine inducible SH2-containing protein
chr6_+_20404033 1.826 NM_001243076
E2F3
E2F transcription factor 3
chr11_-_128392061 1.819 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr8_-_145013628 1.807 NM_201384
PLEC
plectin
chr5_+_133450353 1.796 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr11_-_57194585 1.796 SLC43A3
solute carrier family 43, member 3
chr7_-_5553305 1.771 NM_024963
FBXL18
F-box and leucine-rich repeat protein 18
chr15_-_74726000 1.762 NM_001146030
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr10_-_99160987 1.759 RRP12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr6_-_47277640 1.751 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr5_+_34684611 1.750 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr20_+_62328002 1.745 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr3_+_156392714 1.731 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr1_+_35225341 1.727 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr11_-_57194591 1.718 NM_199329
SLC43A3
solute carrier family 43, member 3
chr14_-_69445772 1.715 ACTN1
actinin, alpha 1
chr6_-_47277645 1.707 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_-_14816895 1.705 NM_031453
FAM107B
family with sequence similarity 107, member B
chr8_+_99076749 1.692 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr11_-_57194556 1.686 SLC43A3
solute carrier family 43, member 3
chr9_+_120466625 1.686 TLR4
toll-like receptor 4
chr4_-_57976516 1.673 IGFBP7
insulin-like growth factor binding protein 7
chr7_+_28338939 1.673 NM_182899
CREB5
cAMP responsive element binding protein 5
chr2_-_160761192 1.672 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chrX_-_19688991 1.664 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr22_-_41842766 1.657 TOB2
transducer of ERBB2, 2
chr4_+_75310852 1.656 NM_001657
AREG
amphiregulin
chr10_-_95360959 1.652 NM_006744
RBP4
retinol binding protein 4, plasma
chr11_-_57194512 1.645 NM_014096
SLC43A3
solute carrier family 43, member 3
chr6_-_47277511 1.645 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr3_+_156392369 1.642 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr19_+_56879687 1.642 ZNF542
zinc finger protein 542
chr3_+_156392204 1.639 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr10_+_127408225 1.637 C10orf137
chromosome 10 open reading frame 137
chr4_+_75480628 1.634 NM_001657
AREG
amphiregulin
chr17_-_46703613 1.634 NM_024017
HOXB9
homeobox B9
chr15_+_69591272 1.610 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chr4_+_8200918 1.594 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr3_+_44754134 1.593 NM_001134440
NM_001134441
NM_001134442
NM_033210
ZNF502



zinc finger protein 502



chr20_+_44034632 1.582 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr20_-_56286540 1.582 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_+_48828627 1.569 NM_001425
EMP3
epithelial membrane protein 3
chr9_+_127631500 1.569 ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr10_-_30348433 1.563 NM_020848
KIAA1462
KIAA1462
chr4_-_57976550 1.560 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr17_-_45928530 1.554 SP6
Sp6 transcription factor
chr19_+_45843997 1.546 NM_177417
KLC3
kinesin light chain 3
chr2_-_160919120 1.536 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr11_+_130318457 1.536 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr6_+_73331570 1.519 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr6_-_47277354 1.517 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr8_-_145018057 1.514 NM_201382
PLEC
plectin
chr1_+_28199053 1.510 NM_001039477
NM_001105556
NM_004848
C1orf38


chromosome 1 open reading frame 38


chr1_-_47082529 1.509 NM_201403
MOB3C
MOB kinase activator 3C
chr7_+_28725597 1.499 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr9_+_130469267 1.495 NM_001012502
C9orf117
chromosome 9 open reading frame 117
chr1_-_115632047 1.491 NM_005725
TSPAN2
tetraspanin 2
chr22_-_39639967 1.488 PDGFB
platelet-derived growth factor beta polypeptide
chr8_-_143695812 1.487 NM_015193
ARC
activity-regulated cytoskeleton-associated protein
chr20_-_22565050 1.483 NM_021784
FOXA2
forkhead box A2
chr14_+_21510384 1.479 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr20_+_44035203 1.476 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr13_-_23949620 1.474 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr7_+_48128939 1.468 UPP1
uridine phosphorylase 1
chr20_-_45318135 1.462 NM_033550
TP53RK
TP53 regulating kinase
chr2_-_110873638 1.448 MALL
mal, T-cell differentiation protein-like
chr2_+_191745912 1.440 GLS
glutaminase
chr16_+_27325269 1.434 IL4R
interleukin 4 receptor
chr17_+_15848230 1.432 NM_000676
ADORA2B
adenosine A2b receptor
chr17_-_38256905 1.423 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr6_+_43738757 1.421 VEGFA
vascular endothelial growth factor A
chr3_+_136537860 1.413 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr4_+_95373044 1.412 PDLIM5
PDZ and LIM domain 5
chr4_+_95373007 1.396 NM_001011513
NM_001011515
NM_001011516
NM_006457
PDLIM5



PDZ and LIM domain 5



chr14_-_67878859 1.396 PLEK2
pleckstrin 2
chr6_+_43738394 1.394 VEGFA
vascular endothelial growth factor A
chr5_-_1494872 1.394 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr12_-_48152860 1.392 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr10_-_69835042 1.382 NM_015601
NM_022079
HERC4

hect domain and RLD 4

chr12_+_65672422 1.378 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr19_-_54984341 1.371 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr2_-_204399906 1.369 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr1_-_95392449 1.367 CNN3
calponin 3, acidic
chr12_-_54813010 1.364 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr7_-_45960738 1.364 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr17_+_2699731 1.361 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr2_-_70781146 1.361 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr10_-_69834950 1.358 HERC4
hect domain and RLD 4
chr10_-_69835012 1.352 HERC4
hect domain and RLD 4
chr19_-_913224 1.352 NM_138774
R3HDM4
R3H domain containing 4
chr2_-_65659634 1.348 NM_181784
SPRED2
sprouty-related, EVH1 domain containing 2
chr10_-_92617670 1.344 NM_000872
NM_019859
NM_019860
HTR7


5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)


chr20_+_62328068 1.339 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr22_-_37915209 1.337 NM_014550
CARD10
caspase recruitment domain family, member 10
chr1_-_175161832 1.335 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr15_+_42840991 1.334 NM_001130447
NM_018097
HAUS2

HAUS augmin-like complex, subunit 2

chr1_+_154300275 1.325 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr19_+_34972866 1.320 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr14_-_67878770 1.311 NM_016445
PLEK2
pleckstrin 2
chr10_-_43762366 1.306 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr2_-_227664330 1.297 IRS1
insulin receptor substrate 1
chr22_-_41842853 1.294 NM_016272
TOB2
transducer of ERBB2, 2
chr12_-_50101127 1.294 FMNL3
formin-like 3
chr11_-_122932806 1.293 HSPA8
heat shock 70kDa protein 8
chr16_+_27325244 1.292 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr1_-_24194760 1.290 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr17_+_29248697 1.289 NM_018404
ADAP2
ArfGAP with dual PH domains 2
chr11_+_45826640 1.281 NM_018389
SLC35C1
solute carrier family 35, member C1
chr19_-_913194 1.280 R3HDM4
R3H domain containing 4
chr3_+_3168599 1.278 NM_182916
TRNT1
tRNA nucleotidyl transferase, CCA-adding, 1
chr9_-_33473846 1.278 NOL6
nucleolar protein family 6 (RNA-associated)
chr8_+_17434700 1.278 PDGFRL
platelet-derived growth factor receptor-like
chr1_+_110753910 1.277 KCNC4
potassium voltage-gated channel, Shaw-related subfamily, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.38 2.50e-04 GO:0009966 regulation of signal transduction
2.17 1.33e-03 GO:0023051 regulation of signaling
2.06 1.55e-03 GO:0048583 regulation of response to stimulus
2.75 2.05e-03 GO:0051128 regulation of cellular component organization
2.78 4.12e-03 GO:2000026 regulation of multicellular organismal development
11.60 1.25e-02 GO:0030193 regulation of blood coagulation
2.44 1.26e-02 GO:0042127 regulation of cell proliferation
10.77 1.95e-02 GO:0050818 regulation of coagulation
10.52 2.24e-02 GO:0051781 positive regulation of cell division
2.16 2.58e-02 GO:0051239 regulation of multicellular organismal process
9.43 4.27e-02 GO:0061041 regulation of wound healing
4.04 4.98e-02 GO:0001558 regulation of cell growth

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.52 1.25e-03 GO:0009986 cell surface
13.47 4.86e-03 GO:0001725 stress fiber
9.63 5.60e-03 GO:0031093 platelet alpha granule lumen
9.43 6.32e-03 GO:0034774 secretory granule lumen
12.57 6.89e-03 GO:0032432 actin filament bundle
9.05 8.01e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
8.70 1.00e-02 GO:0031983 vesicle lumen
11.43 1.11e-02 GO:0042641 actomyosin
7.94 1.69e-02 GO:0031091 platelet alpha granule

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.08 1.01e-03 GO:0008092 cytoskeletal protein binding
3.61 3.90e-03 GO:0003779 actin binding
20.11 7.17e-03 GO:0005161 platelet-derived growth factor receptor binding