Motif ID: EN1,2.p2

Z-value: 1.685


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EN2hg19_v1_chr7_+_155250705_1552508230.579.9e-08Click!
EN1hg19_v1_chr2_-_119605758_1196057580.191.0e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_11674241 10.229 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr14_+_78870092 7.805 NM_004796
NRXN3
neurexin 3
chr15_-_76304762 7.105 NM_138573
NRG4
neuregulin 4
chrX_-_130964633 7.084 LOC286467
family with sequence similarity 195, member A pseudogene
chr10_+_114154522 6.787 ACSL5
acyl-CoA synthetase long-chain family member 5
chrX_-_110513750 6.522 NM_014289
CAPN6
calpain 6
chr3_+_151488214 6.270 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr8_-_82395401 6.190 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr12_+_86268072 5.814 NM_006183
NTS
neurotensin
chr1_+_171154387 5.680 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr17_-_39675078 5.391 NM_002275
KRT15
keratin 15
chr15_+_58430394 5.366 NM_020980
AQP9
aquaporin 9
chr2_+_103035148 5.170 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr3_-_187420344 5.100 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr1_-_166135978 5.041


chr12_-_123201319 4.977 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr1_+_18807423 4.899 NM_152375
KLHDC7A
kelch domain containing 7A
chr8_+_7738725 4.779 NM_001081551
DEFB103A
DEFB103B
defensin, beta 103A
defensin, beta 103B
chr1_-_29309092 4.685


chr12_-_75603510 4.632 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr1_-_152086555 4.547 NM_007113
TCHH
trichohyalin
chrX_+_9431314 4.459 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr4_+_159442865 4.427 NM_001253727
NM_001253728
NM_001253729
NM_001253730
NM_001253732
NM_001253733
NM_021634
RXFP1






relaxin/insulin-like family peptide receptor 1






chr9_+_139871954 4.296 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_86934525 4.282 NM_001285
CLCA1
chloride channel accessory 1
chr10_-_98031154 4.128 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_-_142889269 4.126 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr17_-_9923204 4.094 GAS7
growth arrest-specific 7
chr8_-_87755880 4.081 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr8_+_7738908 4.034 NM_018661
DEFB103B
defensin, beta 103B
chr2_-_163008913 4.020 NM_002054
GCG
glucagon
chr1_-_161039413 3.999 ARHGAP30
Rho GTPase activating protein 30
chr19_-_51512803 3.991 NM_012315
KLK9
kallikrein-related peptidase 9
chr2_-_152590983 3.981 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr18_-_24722757 3.980 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr14_+_23511375 3.956 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr9_+_139872014 3.947 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_160765927 3.926 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr3_-_38992051 3.905 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr11_+_124120422 3.865 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr20_+_34556528 3.804 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr8_+_128427856 3.793 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr11_+_6128913 3.765 NM_001005181
OR56B4
olfactory receptor, family 56, subfamily B, member 4
chr12_+_10460416 3.742 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr19_-_51472816 3.729 NM_002774
KLK6
kallikrein-related peptidase 6
chr15_-_42386657 3.717 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chrX_-_110513665 3.717 CAPN6
calpain 6
chr7_+_117864711 3.713 NM_019644
ANKRD7
ankyrin repeat domain 7
chr10_+_17851342 3.666 NM_002438
MRC1
mannose receptor, C type 1
chr6_-_116447225 3.642 NM_000493
COL10A1
collagen, type X, alpha 1
chr10_-_104179468 3.607 PSD
pleckstrin and Sec7 domain containing
chr17_-_29624249 3.558 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr1_-_161039703 3.550 ARHGAP30
Rho GTPase activating protein 30
chr4_-_48136245 3.462 NM_003328
TXK
TXK tyrosine kinase
chr18_-_24445652 3.454 NM_001650
AQP4
aquaporin 4
chr16_-_81253974 3.440 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr4_+_156824846 3.434 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr4_+_74281884 3.431 ALB
albumin
chr3_-_183273407 3.415 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_-_7436614 3.404 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr9_+_131684561 3.400 NM_001100877
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr12_-_9760481 3.379 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr1_-_166135951 3.376 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr11_-_35547144 3.370 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr10_-_7682741 3.343 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chrX_-_47489703 3.328 NM_002621
CFP
complement factor properdin
chr17_-_39661803 3.307 NM_002274
NM_153490
KRT13

keratin 13

chr11_-_58035630 3.303 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr2_-_142888540 3.271 LRP1B
low density lipoprotein receptor-related protein 1B
chr11_+_124134699 3.266 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr15_-_74659926 3.263 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr7_+_80267922 3.216 CD36
CD36 molecule (thrombospondin receptor)
chr14_+_76837689 3.193 NM_004452
ESRRB
estrogen-related receptor beta
chr10_+_114133838 3.191 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_152956563 3.135 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr5_-_135701163 3.060 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr11_+_60223281 3.030 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr22_-_50523670 3.014 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_+_1776117 2.999


chr6_+_42123143 2.981 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr4_+_40198526 2.970 NM_004310
RHOH
ras homolog gene family, member H
chr5_+_76382458 2.962 LOC728723
uncharacterized LOC728723
chr12_-_95945226 2.950 NM_032147
USP44
ubiquitin specific peptidase 44
chr12_+_100041527 2.942 NM_153364
FAM71C
family with sequence similarity 71, member C
chr3_-_184095927 2.926 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr11_-_6913730 2.925 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr4_-_189026401 2.900 NM_173553
TRIML2
tripartite motif family-like 2
chr5_+_40909558 2.882 NM_000587
C7
complement component 7
chr19_-_56249739 2.876 NM_176820
NLRP9
NLR family, pyrin domain containing 9
chr6_-_32977312 2.876 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr6_+_47624222 2.862 NM_153839
GPR111
G protein-coupled receptor 111
chr18_-_5892102 2.859 NM_001080209
TMEM200C
transmembrane protein 200C
chr10_+_114133775 2.849 ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_-_22853730 2.848 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_-_120401401 2.829 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr7_+_80267782 2.828 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr10_-_104178900 2.803 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr14_+_88471467 2.774 NM_003608
GPR65
G protein-coupled receptor 65
chr7_+_80267972 2.773 CD36
CD36 molecule (thrombospondin receptor)
chr7_+_107110501 2.770 NM_005295
GPR22
G protein-coupled receptor 22
chr9_-_19786886 2.762 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr20_+_43803539 2.759 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr16_-_28518131 2.751 NM_145659
IL27
interleukin 27
chr9_+_107456659 2.744 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr14_-_23588819 2.738 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr1_+_15802595 2.736 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr11_+_124095343 2.718 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr1_-_159684274 2.709 NM_000567
CRP
C-reactive protein, pentraxin-related
chr9_-_34729463 2.685 NM_001141917
FAM205A
family with sequence similarity 205, member A
chr6_-_127780534 2.675 NM_014702
KIAA0408
KIAA0408
chr12_-_10282680 2.651 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_-_161039649 2.648 ARHGAP30
Rho GTPase activating protein 30
chr9_-_75567915 2.640 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_+_71337833 2.627 NM_152291
MUC7
mucin 7, secreted
chr18_+_72201799 2.617 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr12_-_55378455 2.601 NM_001136030
KIAA0748
KIAA0748
chr2_+_137748461 2.589 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr7_-_99277518 2.583 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr8_+_40010986 2.578 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr10_+_123748688 2.560 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr7_-_115670774 2.558 TFEC
transcription factor EC
chr3_+_42727010 2.556 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr10_+_23728197 2.555 NM_001145373
OTUD1
OTU domain containing 1
chr7_-_80141241 2.548 NM_001102386
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr3_-_58522873 2.532 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr11_+_94758421 2.505 NM_001161630
KDM4DL
lysine (K)-specific demethylase 4D-like
chr4_+_71091787 2.502 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr3_+_63638343 2.496 NM_001080537
SNTN
sentan, cilia apical structure protein
chr2_+_68872953 2.486 NM_138964
PROKR1
prokineticin receptor 1
chrX_+_140084755 2.485 NM_145664
NM_139019
NM_032461
SPANXB2
SPANXF1
SPANXB1
SPANX family, member B2
SPANX family, member F1
SPANX family, member B1
chr2_-_209054772 2.476 NM_001099334
C2orf80
chromosome 2 open reading frame 80
chr1_+_152748847 2.454 NM_178354
LCE1F
late cornified envelope 1F
chr7_-_115670811 2.449 TFEC
transcription factor EC
chr10_-_108459000 2.448 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr15_-_50558161 2.445 NM_002112
HDC
histidine decarboxylase
chr3_+_140770742 2.445 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr20_-_30288094 2.431


chr19_+_56459197 2.430 NM_176811
NLRP8
NLR family, pyrin domain containing 8
chr3_-_46505077 2.424 NM_001199149
LTF
lactotransferrin
chr12_-_63328857 2.416 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chrX_+_36254050 2.411 NM_001098843
CXorf30
chromosome X open reading frame 30
chr1_-_154178783 2.406 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr3_+_2280512 2.400 NM_001206955
CNTN4
contactin 4
chr5_+_169816490 2.392


chrX_+_18709044 2.389 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chrX_+_110366304 2.385 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr10_+_95372344 2.379 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr6_+_26273143 2.374 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr11_-_5248180 2.373 NM_000518
HBB
hemoglobin, beta
chr10_+_118380451 2.371 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chrX_+_65235279 2.366


chr13_+_53602829 2.356 NM_006418
OLFM4
olfactomedin 4
chr4_+_71337674 2.356 NM_001145007
MUC7
mucin 7, secreted
chr6_-_32013806 2.349 NM_032470
TNXB
tenascin XB
chr6_-_114384008 2.344 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr9_-_104145800 2.338 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr14_-_94984180 2.338 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr6_-_2635297 2.331 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr19_-_51334747 2.323 NM_017509
NM_138563
NM_138564
KLK15


kallikrein-related peptidase 15


chr5_+_40909617 2.320 C7
complement component 7
chr1_+_226016428 2.306 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr11_+_22696381 2.300 GAS2
growth arrest-specific 2
chr7_-_115670828 2.292 NM_001018058
NM_012252
TFEC

transcription factor EC

chr18_-_31628557 2.290 NM_001198549
NOL4
nucleolar protein 4
chr2_+_234668914 2.285 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr18_+_28956739 2.284 NM_001134453
NM_177986
DSG4

desmoglein 4

chr13_+_113301357 2.283 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr19_-_45663407 2.277 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr4_-_39033981 2.266 NM_024943
TMEM156
transmembrane protein 156
chr10_-_104597079 2.264 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr2_-_217540722 2.260 IGFBP5
insulin-like growth factor binding protein 5
chr2_+_169923531 2.254 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_+_1860718 2.253 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr3_+_169539709 2.253 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chrX_+_41548225 2.247 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr16_+_67381252 2.243 NM_001161575
LRRC36
leucine rich repeat containing 36
chr9_+_74920329 2.235


chr3_-_187452669 2.229 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr19_-_41356193 2.223 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr16_+_58010338 2.223 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr18_+_55712867 2.215 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_105238996 2.199 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr18_+_43306917 2.196 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr1_-_151798552 2.192 NM_001001523
RORC
RAR-related orphan receptor C
chr8_+_133879202 2.191 NM_003235
TG
thyroglobulin
chr19_-_54327428 2.182 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr6_-_32977351 2.179 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr2_+_233390869 2.174 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr7_+_140103842 2.173 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr1_-_198906536 2.162 LOC100131234
familial acute myelogenous leukemia related factor
chr21_-_19775958 2.161 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr5_+_60933635 2.156 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr7_+_23286420 2.143 GPNMB
glycoprotein (transmembrane) nmb
chr11_+_7506599 2.138 NM_198474
OLFML1
olfactomedin-like 1
chr1_-_216978708 2.137 NM_001243514
ESRRG
estrogen-related receptor gamma
chr12_-_22089627 2.134 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr11_+_4660944 2.128 NM_001004751
OR51D1
olfactory receptor, family 51, subfamily D, member 1
chr6_+_30104509 2.125 NM_138700
TRIM40
tripartite motif containing 40
chr17_-_32483550 2.124 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr17_+_7384720 2.123 NM_001102614
SLC35G6
solute carrier family 35, member G6

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.44 1.69e-06 GO:0050896 response to stimulus
5.49 2.84e-04 GO:0051606 detection of stimulus
11.70 2.88e-04 GO:0007602 phototransduction
9.49 1.65e-03 GO:0009583 detection of light stimulus
2.32 2.71e-03 GO:0006955 immune response
2.77 3.29e-03 GO:0050776 regulation of immune response
1.97 3.42e-03 GO:0002376 immune system process
6.27 4.43e-03 GO:0009581 detection of external stimulus
2.20 4.77e-03 GO:0007600 sensory perception
6.81 6.75e-03 GO:0009582 detection of abiotic stimulus
1.76 8.29e-03 GO:0003008 system process
2.14 1.67e-02 GO:0006952 defense response
21.93 1.97e-02 GO:0007603 phototransduction, visible light
1.34 3.34e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.98 5.26e-08 GO:0005576 extracellular region
1.57 3.32e-07 GO:0071944 cell periphery
1.57 4.72e-07 GO:0005886 plasma membrane
1.64 1.61e-03 GO:0044459 plasma membrane part
1.33 2.92e-03 GO:0031224 intrinsic to membrane
1.29 4.55e-03 GO:0044425 membrane part
1.79 1.24e-02 GO:0031226 intrinsic to plasma membrane
3.82 1.52e-02 GO:0009897 external side of plasma membrane
1.78 1.58e-02 GO:0005887 integral to plasma membrane
1.23 1.71e-02 GO:0016020 membrane
14.62 2.31e-02 GO:0001518 voltage-gated sodium channel complex
1.82 3.85e-02 GO:0044421 extracellular region part
12.53 4.51e-02 GO:0042613 MHC class II protein complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.71 6.30e-04 GO:0004871 signal transducer activity
1.71 6.30e-04 GO:0060089 molecular transducer activity
1.75 2.06e-03 GO:0004872 receptor activity
1.85 5.00e-03 GO:0004888 transmembrane receptor activity
2.42 3.89e-02 GO:0015267 channel activity
2.42 4.03e-02 GO:0022803 passive transmembrane transporter activity