Motif ID: E2F1..5.p2

Z-value: 3.773


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F2hg19_v1_chr1_-_23857711_238577110.823.9e-19Click!
E2F1hg19_v1_chr20_-_32274154_322742410.704.5e-12Click!
E2F5hg19_v1_chr8_+_86089618_86089625-0.217.1e-02Click!
E2F4hg19_v1_chr16_+_67226070_67226097-0.171.3e-01Click!
E2F3hg19_v1_chr6_+_20404033_20404033-0.132.6e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_23857711 26.507 NM_004091
E2F2
E2F transcription factor 2
chr1_-_23857284 24.684 E2F2
E2F transcription factor 2
chr15_+_25200069 24.070 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr6_+_135502521 23.950 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135502445 23.444 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr19_+_15218141 19.223 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr22_-_38966066 18.845 NM_007068
DMC1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
chr22_+_38201232 18.817 H1F0
H1 histone family, member 0
chr17_-_27949814 17.531 CORO6
coronin 6
chr22_+_38201300 17.222 H1F0
H1 histone family, member 0
chr20_-_35724330 15.192 RBL1
retinoblastoma-like 1 (p107)
chr20_-_35724401 15.131 NM_002895
NM_183404
RBL1

retinoblastoma-like 1 (p107)

chr22_+_38201113 15.055 NM_005318
H1F0
H1 histone family, member 0
chr19_+_4909447 14.575 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr9_-_99180661 14.175 NM_153695
ZNF367
zinc finger protein 367
chr20_-_32274070 13.289 E2F1
E2F transcription factor 1
chr22_+_35796104 13.251 NM_006739
MCM5
minichromosome maintenance complex component 5
chr1_-_36235422 13.032 NM_001190481
NM_022111
CLSPN

claspin

chr22_+_35796154 12.841 MCM5
minichromosome maintenance complex component 5
chr9_-_99180539 11.794 ZNF367
zinc finger protein 367
chr11_-_19262424 11.032 NM_024680
E2F8
E2F transcription factor 8
chr1_+_3569098 11.011 NM_001204184
NM_001204185
NM_001204186
NM_001204187
NM_001204188
NM_005427
TP73





tumor protein p73





chr6_-_52149472 10.987 MCM3
minichromosome maintenance complex component 3
chr20_-_32274154 10.907 NM_005225
E2F1
E2F transcription factor 1
chr11_-_19263144 10.828 E2F8
E2F transcription factor 8
chr6_-_52149516 10.804 MCM3
minichromosome maintenance complex component 3
chr6_-_52149541 10.784 NM_002388
MCM3
minichromosome maintenance complex component 3
chr3_+_127317271 10.716 MCM2
minichromosome maintenance complex component 2
chr19_+_4910166 10.690 UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr3_+_127317212 10.678 NM_004526
MCM2
minichromosome maintenance complex component 2
chr3_+_127317274 10.675 MCM2
minichromosome maintenance complex component 2
chr1_+_212208918 10.660 NM_016448
DTL
denticleless homolog (Drosophila)
chr20_-_5100443 10.591 NM_182649
PCNA
proliferating cell nuclear antigen
chr22_+_35796294 10.524 MCM5
minichromosome maintenance complex component 5
chr10_+_96305521 10.368 NM_018063
HELLS
helicase, lymphoid-specific
chr11_+_65029312 10.220 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr13_+_32889594 10.193 NM_000059
BRCA2
breast cancer 2, early onset
chr1_+_212209112 10.147 DTL
denticleless homolog (Drosophila)
chrX_-_64254592 9.886 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr1_+_212209129 9.705 DTL
denticleless homolog (Drosophila)
chr12_-_12849120 9.611 NM_006143
GPR19
G protein-coupled receptor 19
chr2_-_136633934 9.496 MCM6
minichromosome maintenance complex component 6
chr19_+_36545757 9.490 NM_001083961
NM_173636
WDR62

WD repeat domain 62

chr7_-_99699426 9.275 NM_005916
MCM7
minichromosome maintenance complex component 7
chr2_-_136634002 9.236 NM_005915
MCM6
minichromosome maintenance complex component 6
chr5_-_146889420 9.039 DPYSL3
dihydropyrimidinase-like 3
chr7_-_99698916 9.005 MCM7
minichromosome maintenance complex component 7
chr8_-_67525426 8.744 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

uncharacterized LOC645895
chr2_-_27485774 8.660 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr11_-_108368918 8.544 NM_153705
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2
chr3_+_44803280 8.443 KIF15
kinesin family member 15
chr7_-_99698993 8.432 MCM7
minichromosome maintenance complex component 7
chr19_+_36545804 8.330 WDR62
WD repeat domain 62
chr7_-_99699030 8.306 MCM7
minichromosome maintenance complex component 7
chr7_+_121513158 8.285 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr2_-_130902568 8.214 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr3_+_44803208 8.030 NM_020242
KIF15
kinesin family member 15
chr19_-_10305536 7.969 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr1_-_149812733 7.734 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr11_+_77850824 7.650 LOC100289388
uncharacterized LOC100289388
chr9_+_86595636 7.647 NM_024945
RMI1
RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr11_+_64067862 7.599 NM_001039496
C11orf20
chromosome 11 open reading frame 20
chr15_+_47476225 7.331 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_+_132129154 7.314 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr8_+_121457642 7.296 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr2_+_132285469 7.237 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr19_+_36545848 7.131 WDR62
WD repeat domain 62
chr8_-_124408665 6.908 ATAD2
ATPase family, AAA domain containing 2
chr6_+_31126340 6.886 TCF19
transcription factor 19
chr19_+_4910339 6.873 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr17_+_38444134 6.845 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr15_-_40401041 6.807 NM_001003940
BMF
Bcl2 modifying factor
chr19_-_10305600 6.762 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr6_+_132129195 6.667 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr8_-_124408688 6.613 NM_014109
ATAD2
ATPase family, AAA domain containing 2
chr10_+_13203547 6.563 NM_018518
NM_182751
MCM10

minichromosome maintenance complex component 10

chr17_+_38444130 6.530 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr8_+_48873533 6.480 MCM4
minichromosome maintenance complex component 4
chr16_+_88870185 6.364 NM_030928
CDT1
chromatin licensing and DNA replication factor 1
chr16_+_11439279 6.324 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr1_-_221915458 6.305 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr5_-_146889618 6.301 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr17_+_38444151 6.245 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr16_+_11439311 6.095 RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr8_-_124408458 6.078 ATAD2
ATPase family, AAA domain containing 2
chr10_+_62538250 6.064 CDK1
cyclin-dependent kinase 1
chr10_+_62538088 6.062 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr1_-_221915393 6.021 DUSP10
dual specificity phosphatase 10
chr16_-_85722503 6.016 GINS2
GINS complex subunit 2 (Psf2 homolog)
chr16_-_85722587 6.011 NM_016095
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr5_+_126113050 6.006 LMNB1
lamin B1
chr4_+_166794409 5.995 NM_001204760
NM_012464
TLL1

tolloid-like 1

chr19_-_37663567 5.983 NM_152655
ZNF585A
zinc finger protein 585A
chrX_+_24712043 5.978 POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr6_+_31126114 5.969 NM_001077511
NM_007109
TCF19

transcription factor 19

chr1_-_108507474 5.964 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr8_-_95907423 5.921 NM_057749
CCNE2
cyclin E2
chr22_+_21356434 5.908 THAP7-AS1
THAP7 antisense RNA 1 (non-protein coding)
chr14_-_55658205 5.865 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr19_-_10305645 5.863 NM_001130823
NM_001379
DNMT1

DNA (cytosine-5-)-methyltransferase 1

chr4_+_178231013 5.810 NEIL3
nei endonuclease VIII-like 3 (E. coli)
chrX_+_24712063 5.803 NM_016937
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr8_-_143859638 5.800 NM_023946
NM_177457
LYNX1

Ly6/neurotoxin 1

chr2_-_219432955 5.774 NM_020935
USP37
ubiquitin specific peptidase 37
chr6_+_135502477 5.773 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr5_-_79950348 5.773 DHFR
dihydrofolate reductase
chr15_+_44719831 5.767 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr2_+_10262853 5.750 NM_001034
RRM2
ribonucleotide reductase M2
chr4_+_178230979 5.718 NM_018248
NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr6_-_26250832 5.691 NM_021018
HIST1H3J
HIST1H3F
histone cluster 1, H3j
histone cluster 1, H3f
chr20_-_44563684 5.686 FLJ40606
uncharacterized LOC643549
chrX_+_53449804 5.670 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chr8_-_124408669 5.617 ATAD2
ATPase family, AAA domain containing 2
chr16_+_88870214 5.615 CDT1
chromatin licensing and DNA replication factor 1
chr14_+_85999464 5.601


chr8_+_48873510 5.591 MCM4
minichromosome maintenance complex component 4
chr5_-_79950307 5.591 DHFR
dihydrofolate reductase
chr2_-_216300444 5.576 FN1
fibronectin 1
chr11_-_64851449 5.568 CDCA5
cell division cycle associated 5
chr9_-_23821842 5.568 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr14_-_50154920 5.545 POLE2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr6_+_26225382 5.512 NM_003532
HIST1H3E
histone cluster 1, H3e
chr5_+_126112819 5.509 NM_001198557
LMNB1
lamin B1
chr6_+_26045611 5.483 NM_003531
HIST1H3C
histone cluster 1, H3c
chr8_-_143859177 5.476 LYNX1
Ly6/neurotoxin 1
chr9_-_123639462 5.452 PHF19
PHD finger protein 19
chr9_-_23821808 5.441 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr15_+_66994669 5.380 NM_005585
SMAD6
SMAD family member 6
chr16_-_30103204 5.283 NM_004608
TBX6
T-box 6
chr17_+_29158948 5.278 NM_024857
ATAD5
ATPase family, AAA domain containing 5
chr6_+_27100784 5.265 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr11_+_9595309 5.259 WEE1
WEE1 homolog (S. pombe)
chr2_+_10262694 5.248 NM_001165931
RRM2
ribonucleotide reductase M2
chr12_-_2113584 5.142 NM_152640
DCP1B
DCP1 decapping enzyme homolog B (S. cerevisiae)
chr14_-_50155097 5.132 NM_001197330
NM_001197331
NM_002692
POLE2


polymerase (DNA directed), epsilon 2 (p59 subunit)


chr5_-_79950783 5.121 NM_000791
DHFR
dihydrofolate reductase
chr4_-_105412466 5.118 NM_025212
CXXC4
CXXC finger protein 4
chr2_+_71680752 5.101 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chr7_+_121513210 5.098 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr1_-_221915426 5.045 DUSP10
dual specificity phosphatase 10
chr6_-_153304093 5.038 NM_012177
FBXO5
F-box protein 5
chr1_-_26232643 5.033 NM_203401
STMN1
stathmin 1
chr9_+_126774028 5.028 LHX2
LIM homeobox 2
chr2_-_216300770 5.011 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr3_-_14220071 5.005 NM_001145769
NM_004628
XPC

xeroderma pigmentosum, complementation group C

chr8_+_48873446 4.983 MCM4
minichromosome maintenance complex component 4
chr15_+_44719765 4.924 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr22_+_42394728 4.889 NM_152613
WBP2NL
WBP2 N-terminal like
chr1_-_100598406 4.887 NM_194292
SASS6
spindle assembly 6 homolog (C. elegans)
chr3_+_121554029 4.858 NM_018456
EAF2
ELL associated factor 2
chrX_-_53449548 4.831 SMC1A
structural maintenance of chromosomes 1A
chr8_-_120868034 4.770 NM_024094
DSCC1
defective in sister chromatid cohesion 1 homolog (S. cerevisiae)
chr21_-_47743753 4.758 NM_058180
C21orf58
chromosome 21 open reading frame 58
chr3_+_10068139 4.727 FANCD2
Fanconi anemia, complementation group D2
chr9_-_35079520 4.720 FANCG
Fanconi anemia, complementation group G
chr10_+_23728197 4.715 NM_001145373
OTUD1
OTU domain containing 1
chr9_+_114287438 4.683 NM_001007169
NM_133464
ZNF483

zinc finger protein 483

chr7_+_129074235 4.681 NM_001134336
NM_020704
FAM40B

family with sequence similarity 40, member B

chr10_+_48355002 4.669 NM_153034
ZNF488
zinc finger protein 488
chr12_-_45269340 4.663 NM_001145109
NELL2
NEL-like 2 (chicken)
chr1_-_47779651 4.641 NM_001048166
NM_003035
STIL

SCL/TAL1 interrupting locus

chr3_+_10068123 4.638 FANCD2
Fanconi anemia, complementation group D2
chr1_+_61542790 4.618


chr7_-_148581377 4.604 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_+_242011471 4.591 NM_130398
EXO1
exonuclease 1
chr7_+_94139331 4.573 CASD1
CAS1 domain containing 1
chr11_+_9595183 4.535 NM_003390
WEE1
WEE1 homolog (S. pombe)
chr15_+_40763159 4.511 NM_130468
CHST14
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
chr3_+_10068097 4.437 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr6_-_132272311 4.426 NM_001901
CTGF
connective tissue growth factor
chr15_+_91260575 4.411 NM_000057
BLM
Bloom syndrome, RecQ helicase-like
chr4_-_146859960 4.401


chr2_+_61108702 4.396 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr1_+_242011544 4.371 EXO1
exonuclease 1
chr12_+_72666462 4.368 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr7_-_95225802 4.365 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chrX_+_100353156 4.361 CENPI
centromere protein I
chr9_-_113800980 4.356 LPAR1
lysophosphatidic acid receptor 1
chr11_+_74303626 4.350 NM_006591
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr4_-_113558021 4.336 C4orf21
chromosome 4 open reading frame 21
chr7_-_148581297 4.311 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr2_+_61108724 4.256 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr3_-_49893885 4.248 NM_005879
TRAIP
TRAF interacting protein
chr2_+_174219537 4.237 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr8_-_145669796 4.229 NM_013432
TONSL
tonsoku-like, DNA repair protein
chr7_-_148581379 4.229 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr2_+_61108775 4.216 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr12_-_45270071 4.194 NELL2
NEL-like 2 (chicken)
chr8_+_27631902 4.171 NM_001017420
ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr7_-_148581359 4.171 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_158497432 4.167 NM_017760
NCAPG2
non-SMC condensin II complex, subunit G2
chr1_-_110052285 4.164 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr7_-_148581403 4.156 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr10_-_58121019 4.143 NM_001005413
NM_007057
NM_032997
ZWINT


ZW10 interactor


chrX_-_53449610 4.133 NM_006306
SMC1A
structural maintenance of chromosomes 1A
chr10_-_58121011 4.127 ZWINT
ZW10 interactor
chr16_+_2510080 4.124 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr9_-_113800243 4.090 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr12_+_53662000 4.081 NM_012291
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr15_-_71184611 4.072 NM_020147
THAP10
THAP domain containing 10

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.95 2.07e-47 GO:0007049 cell cycle
5.95 1.86e-44 GO:0022403 cell cycle phase
5.22 8.87e-41 GO:0022402 cell cycle process
5.88 8.61e-37 GO:0006259 DNA metabolic process
5.85 1.40e-35 GO:0000278 mitotic cell cycle
7.23 1.65e-31 GO:0010564 regulation of cell cycle process
4.94 2.88e-27 GO:0051726 regulation of cell cycle
9.56 3.87e-27 GO:0006260 DNA replication
4.95 6.77e-27 GO:0051276 chromosome organization
6.80 1.67e-24 GO:0051325 interphase
6.79 6.55e-24 GO:0051329 interphase of mitotic cell cycle
5.56 1.37e-23 GO:0000279 M phase
2.87 1.51e-21 GO:0006996 organelle organization
14.45 9.73e-21 GO:0006261 DNA-dependent DNA replication
4.79 1.13e-20 GO:0006974 response to DNA damage stimulus
5.75 1.23e-19 GO:0006281 DNA repair
7.06 4.23e-18 GO:0000075 cell cycle checkpoint
2.04 4.30e-18 GO:0016043 cellular component organization
2.38 6.36e-18 GO:0090304 nucleic acid metabolic process
23.63 1.43e-17 GO:0006271 DNA strand elongation involved in DNA replication
6.79 1.68e-17 GO:0071156 regulation of cell cycle arrest
9.91 2.25e-17 GO:0051320 S phase
2.21 3.37e-17 GO:0071842 cellular component organization at cellular level
22.05 7.59e-17 GO:0022616 DNA strand elongation
1.97 1.17e-16 GO:0071840 cellular component organization or biogenesis
8.40 1.56e-16 GO:0000082 G1/S transition of mitotic cell cycle
9.73 1.85e-16 GO:0000084 S phase of mitotic cell cycle
5.70 3.13e-16 GO:0000280 nuclear division
5.70 3.13e-16 GO:0007067 mitosis
2.13 8.05e-16 GO:0071841 cellular component organization or biogenesis at cellular level
5.54 9.06e-16 GO:0000087 M phase of mitotic cell cycle
5.52 1.03e-15 GO:0048285 organelle fission
3.37 3.84e-15 GO:0033554 cellular response to stress
2.05 5.09e-14 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
7.78 8.75e-14 GO:0006310 DNA recombination
7.10 1.00e-12 GO:0071103 DNA conformation change
4.64 1.20e-12 GO:0051301 cell division
23.35 1.00e-11 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
7.36 1.87e-11 GO:0006323 DNA packaging
1.86 2.32e-11 GO:0034641 cellular nitrogen compound metabolic process
1.81 1.43e-10 GO:0006807 nitrogen compound metabolic process
21.40 5.27e-10 GO:2000104 negative regulation of DNA-dependent DNA replication
7.56 1.84e-09 GO:0007059 chromosome segregation
19.46 2.11e-09 GO:0006270 DNA-dependent DNA replication initiation
7.34 3.24e-09 GO:0065004 protein-DNA complex assembly
18.61 3.96e-09 GO:0090329 regulation of DNA-dependent DNA replication
6.34 5.57e-09 GO:0006333 chromatin assembly or disassembly
7.62 5.77e-09 GO:0031497 chromatin assembly
3.54 8.04e-09 GO:0006325 chromatin organization
6.95 9.44e-09 GO:0071824 protein-DNA complex subunit organization
1.60 1.11e-08 GO:0044260 cellular macromolecule metabolic process
20.48 1.17e-08 GO:0032201 telomere maintenance via semi-conservative replication
8.48 1.30e-08 GO:0000216 M/G1 transition of mitotic cell cycle
7.25 1.47e-08 GO:0034728 nucleosome organization
16.46 2.11e-08 GO:0006312 mitotic recombination
19.46 2.29e-08 GO:0000722 telomere maintenance via recombination
10.68 3.19e-08 GO:0051053 negative regulation of DNA metabolic process
1.39 7.28e-08 GO:0050794 regulation of cellular process
25.94 1.13e-07 GO:0071897 DNA biosynthetic process
1.22 1.25e-07 GO:0009987 cellular process
2.09 1.36e-07 GO:0034645 cellular macromolecule biosynthetic process
12.29 1.42e-07 GO:0008156 negative regulation of DNA replication
1.51 1.86e-07 GO:0043170 macromolecule metabolic process
7.19 2.11e-07 GO:0006334 nucleosome assembly
2.06 2.44e-07 GO:0009059 macromolecule biosynthetic process
1.79 2.55e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.64 4.79e-07 GO:0051052 regulation of DNA metabolic process
4.15 4.99e-07 GO:0007346 regulation of mitotic cell cycle
1.36 5.00e-07 GO:0050789 regulation of biological process
1.75 7.18e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.33 7.91e-07 GO:0065007 biological regulation
7.30 2.10e-06 GO:0006275 regulation of DNA replication
19.46 2.70e-06 GO:0006297 nucleotide-excision repair, DNA gap filling
9.73 2.90e-06 GO:0000723 telomere maintenance
6.07 3.28e-06 GO:0007126 meiosis
6.07 3.28e-06 GO:0051327 M phase of meiotic cell cycle
9.53 3.76e-06 GO:0007051 spindle organization
9.53 3.76e-06 GO:0032200 telomere organization
6.02 3.79e-06 GO:0051321 meiotic cell cycle
2.82 4.21e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
12.55 4.27e-06 GO:0010833 telomere maintenance via telomere lengthening
2.78 6.04e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
10.44 6.13e-06 GO:0000070 mitotic sister chromatid segregation
2.76 7.39e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
17.30 8.76e-06 GO:0007062 sister chromatid cohesion
5.03 9.48e-06 GO:0000226 microtubule cytoskeleton organization
9.73 1.39e-05 GO:0000819 sister chromatid segregation
2.64 2.61e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.72 3.56e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
5.51 4.07e-05 GO:0031570 DNA integrity checkpoint
1.70 6.51e-05 GO:0010556 regulation of macromolecule biosynthetic process
2.53 8.11e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.54 9.41e-05 GO:0031323 regulation of cellular metabolic process
12.97 1.29e-04 GO:0033261 regulation of S phase
2.48 1.42e-04 GO:0009890 negative regulation of biosynthetic process
1.73 1.54e-04 GO:0006355 regulation of transcription, DNA-dependent
21.23 1.66e-04 GO:0000076 DNA replication checkpoint
21.23 1.66e-04 GO:0032297 negative regulation of DNA-dependent DNA replication initiation
6.87 1.92e-04 GO:0006289 nucleotide-excision repair
1.71 2.13e-04 GO:0051252 regulation of RNA metabolic process
1.52 2.61e-04 GO:0080090 regulation of primary metabolic process
1.48 2.63e-04 GO:0019222 regulation of metabolic process
1.54 2.85e-04 GO:0060255 regulation of macromolecule metabolic process
6.40 4.32e-04 GO:0006338 chromatin remodeling
6.31 5.04e-04 GO:0045787 positive regulation of cell cycle
2.09 5.25e-04 GO:0022607 cellular component assembly
1.61 5.35e-04 GO:0009889 regulation of biosynthetic process
13.62 5.83e-04 GO:0006298 mismatch repair
1.61 5.92e-04 GO:0031326 regulation of cellular biosynthetic process
2.18 6.33e-04 GO:0010605 negative regulation of macromolecule metabolic process
3.44 6.45e-04 GO:0007017 microtubule-based process
1.70 7.01e-04 GO:0048523 negative regulation of cellular process
3.01 7.78e-04 GO:0016568 chromatin modification
24.32 8.37e-04 GO:0000731 DNA synthesis involved in DNA repair
24.32 8.37e-04 GO:0007064 mitotic sister chromatid cohesion
24.32 8.37e-04 GO:0045005 maintenance of fidelity involved in DNA-dependent DNA replication
2.30 9.70e-04 GO:0071844 cellular component assembly at cellular level
16.68 1.01e-03 GO:0030174 regulation of DNA-dependent DNA replication initiation
2.16 1.16e-03 GO:0031324 negative regulation of cellular metabolic process
1.63 1.21e-03 GO:0006950 response to stress
2.74 1.22e-03 GO:0008283 cell proliferation
5.63 1.81e-03 GO:0000236 mitotic prometaphase
2.08 1.82e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
21.62 1.84e-03 GO:0007063 regulation of sister chromatid cohesion
1.60 1.86e-03 GO:0010468 regulation of gene expression
2.06 2.27e-03 GO:0009892 negative regulation of metabolic process
11.35 2.38e-03 GO:0031055 chromatin remodeling at centromere
9.16 2.54e-03 GO:0006284 base-excision repair
14.59 2.58e-03 GO:0051983 regulation of chromosome segregation
2.90 2.64e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.89 2.79e-03 GO:0034622 cellular macromolecular complex assembly
1.61 2.98e-03 GO:0044249 cellular biosynthetic process
10.90 3.24e-03 GO:0043486 histone exchange
2.27 3.60e-03 GO:0065003 macromolecular complex assembly
1.90 6.53e-03 GO:0044085 cellular component biogenesis
9.73 7.47e-03 GO:0043044 ATP-dependent chromatin remodeling
1.58 8.35e-03 GO:0048519 negative regulation of biological process
5.29 9.44e-03 GO:0007088 regulation of mitosis
5.29 9.44e-03 GO:0051783 regulation of nuclear division
1.56 9.79e-03 GO:0009058 biosynthetic process
1.28 1.11e-02 GO:0044238 primary metabolic process
7.59 1.15e-02 GO:0006283 transcription-coupled nucleotide-excision repair
2.06 1.54e-02 GO:0043933 macromolecular complex subunit organization
11.12 1.57e-02 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
11.12 1.57e-02 GO:0016444 somatic cell DNA recombination
5.56 1.58e-02 GO:0006302 double-strand break repair
2.54 1.75e-02 GO:0032583 regulation of gene-specific transcription
2.43 1.91e-02 GO:0034621 cellular macromolecular complex subunit organization
8.51 1.94e-02 GO:0000724 double-strand break repair via homologous recombination
8.51 1.94e-02 GO:0000725 recombinational repair
10.61 2.11e-02 GO:0006336 DNA replication-independent nucleosome assembly
10.61 2.11e-02 GO:0034080 CenH3-containing nucleosome assembly at centromere
10.61 2.11e-02 GO:0034724 DNA replication-independent nucleosome organization
4.45 2.20e-02 GO:0090068 positive regulation of cell cycle process
4.41 2.43e-02 GO:0000077 DNA damage checkpoint
38.91 2.51e-02 GO:0010216 maintenance of DNA methylation
38.91 2.51e-02 GO:0048478 replication fork protection
4.29 3.23e-02 GO:0060249 anatomical structure homeostasis
2.84 3.81e-02 GO:0002520 immune system development
19.46 4.08e-02 GO:0033599 regulation of mammary gland epithelial cell proliferation
9.34 4.70e-02 GO:0002200 somatic diversification of immune receptors

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.92 1.31e-33 GO:0005634 nucleus
5.57 6.12e-33 GO:0005694 chromosome
2.98 5.50e-30 GO:0031981 nuclear lumen
5.76 4.40e-29 GO:0044427 chromosomal part
2.71 5.86e-28 GO:0044428 nuclear part
3.27 7.00e-26 GO:0005654 nucleoplasm
2.47 2.04e-22 GO:0070013 intracellular organelle lumen
2.44 4.11e-22 GO:0043233 organelle lumen
2.40 1.93e-21 GO:0031974 membrane-enclosed lumen
1.35 7.45e-16 GO:0043226 organelle
1.28 1.06e-15 GO:0044424 intracellular part
1.35 1.34e-15 GO:0043229 intracellular organelle
5.92 2.71e-15 GO:0000785 chromatin
1.39 3.36e-15 GO:0043231 intracellular membrane-bounded organelle
1.39 4.07e-15 GO:0043227 membrane-bounded organelle
6.12 8.86e-15 GO:0000228 nuclear chromosome
2.03 1.15e-14 GO:0043228 non-membrane-bounded organelle
2.03 1.15e-14 GO:0043232 intracellular non-membrane-bounded organelle
1.25 4.59e-14 GO:0005622 intracellular
1.54 1.88e-11 GO:0044446 intracellular organelle part
14.73 3.11e-11 GO:0005657 replication fork
5.95 4.09e-11 GO:0044454 nuclear chromosome part
1.52 4.28e-11 GO:0044422 organelle part
5.88 1.15e-08 GO:0000793 condensed chromosome
5.76 1.73e-08 GO:0000775 chromosome, centromeric region
6.56 4.60e-07 GO:0032993 protein-DNA complex
29.18 1.60e-06 GO:0042555 MCM complex
14.15 8.74e-06 GO:0043596 nuclear replication fork
3.91 1.01e-05 GO:0005813 centrosome
16.02 2.33e-05 GO:0030894 replisome
16.02 2.33e-05 GO:0043601 nuclear replisome
2.45 2.97e-05 GO:0015630 microtubule cytoskeleton
4.13 3.55e-05 GO:0005819 spindle
2.30 1.56e-04 GO:0044451 nucleoplasm part
21.62 2.75e-04 GO:0005721 centromeric heterochromatin
1.46 4.37e-04 GO:0032991 macromolecular complex
2.88 6.88e-04 GO:0005815 microtubule organizing center
1.49 1.42e-03 GO:0043234 protein complex
5.84 4.37e-03 GO:0000786 nucleosome
1.83 7.49e-03 GO:0044430 cytoskeletal part
5.66 1.60e-02 GO:0000794 condensed nuclear chromosome
6.19 2.54e-02 GO:0000792 heterochromatin
4.55 3.26e-02 GO:0000779 condensed chromosome, centromeric region
23.35 3.60e-02 GO:0005663 DNA replication factor C complex
1.05 4.48e-02 GO:0044464 cell part
1.05 4.54e-02 GO:0005623 cell

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.32 2.10e-19 GO:0003677 DNA binding
1.82 2.07e-12 GO:0003676 nucleic acid binding
1.19 1.91e-08 GO:0005488 binding
1.34 2.14e-07 GO:0005515 protein binding
8.03 1.57e-06 GO:0008094 DNA-dependent ATPase activity
8.19 4.84e-06 GO:0003697 single-stranded DNA binding
8.92 7.54e-06 GO:0003684 damaged DNA binding
4.21 1.66e-05 GO:0043566 structure-specific DNA binding
4.19 1.82e-05 GO:0003682 chromatin binding
10.48 8.75e-04 GO:0003887 DNA-directed DNA polymerase activity
1.97 1.60e-03 GO:0001071 nucleic acid binding transcription factor activity
1.97 1.60e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
25.94 1.84e-03 GO:0032135 DNA insertion or deletion binding
9.39 1.94e-03 GO:0034061 DNA polymerase activity
16.21 2.20e-03 GO:0000217 DNA secondary structure binding
38.91 5.06e-03 GO:0000404 loop DNA binding
38.91 5.06e-03 GO:0032139 dinucleotide insertion or deletion binding
13.90 5.32e-03 GO:0030983 mismatched DNA binding
1.88 6.56e-03 GO:0030528 transcription regulator activity
2.73 9.01e-03 GO:0016564 transcription repressor activity
3.75 1.25e-02 GO:0003690 double-stranded DNA binding
2.00 3.32e-02 GO:0043565 sequence-specific DNA binding