Motif ID: CRX.p2

Z-value: 0.715


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CRXhg19_v1_chr19_+_48325098_483252120.243.8e-02Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224467049 3.875 SCG2
secretogranin II
chr17_-_39092714 3.524 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_224467142 3.018 NM_003469
SCG2
secretogranin II
chr2_-_224467095 3.005 SCG2
secretogranin II
chr7_+_37779995 2.823 NM_181791
GPR141
G protein-coupled receptor 141
chr10_+_123754141 2.584 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_24877453 2.357 NM_015864
FAM65B
family with sequence similarity 65, member B
chr19_-_17516383 1.997 NM_004335
BST2
bone marrow stromal cell antigen 2
chr7_-_122342965 1.933 NM_198085
RNF148
ring finger protein 148
chr2_-_31030271 1.910 NM_144575
CAPN13
calpain 13
chr4_-_184243578 1.778 NM_001185149
CLDN24
claudin 24
chrM_+_8857 1.701


chr20_-_44006876 1.671 NM_014477
TP53TG5
TP53 target 5
chr17_+_38465422 1.652 NM_000964
RARA
retinoic acid receptor, alpha
chr19_+_45174723 1.623 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr20_+_43803539 1.615 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr1_+_196621007 1.569 NM_000186
NM_001014975
CFH

complement factor H

chr12_-_89746244 1.564 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr19_-_55668956 1.549 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr12_-_89745753 1.513 DUSP6
dual specificity phosphatase 6
chr6_-_133078894 1.427 NM_001242350
NM_004665
VNN2

vanin 2

chr12_-_16757944 1.415 LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_42908178 1.370 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr3_+_157154579 1.369 NM_002852
PTX3
pentraxin 3, long
chrM_-_9203 1.294


chr16_-_72128214 1.263 NM_001142318
TXNL4B
thioredoxin-like 4B
chr20_-_34243118 1.254 RBM12
RNA binding motif protein 12
chr11_-_102714240 1.241 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chrM_+_9182 1.218


chr9_-_112970412 1.218 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr12_-_89746238 1.215 DUSP6
dual specificity phosphatase 6
chr19_+_48949029 1.212 NM_031485
GRWD1
glutamate-rich WD repeat containing 1
chr2_+_102608305 1.167 NM_004633
IL1R2
interleukin 1 receptor, type II
chr1_-_110155672 1.162 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chrM_+_3920 1.156


chr1_-_153067000 1.148 NM_001024209
SPRR2E
small proline-rich protein 2E
chr19_+_37180301 1.133 NM_152603
ZNF567
zinc finger protein 567
chrM_+_8364 1.133


chr2_+_228678556 1.126 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr7_+_112063131 1.118 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chrM_+_9217 1.107


chr11_-_128457452 1.103 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_-_153044083 1.061 NM_001017418
SPRR2B
small proline-rich protein 2B
chr5_+_159614373 1.057 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr2_+_234590583 1.046 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr10_-_82049178 1.046 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr19_-_6670598 1.041 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr11_+_66742747 1.036 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr19_+_48325098 1.006 NM_000554
CRX
cone-rod homeobox
chr1_+_160085519 1.003 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr10_+_5005685 0.997 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_+_99332197 0.994 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr12_-_7596722 0.975 NM_174941
CD163L1
CD163 molecule-like 1
chr8_+_26150731 0.964 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr8_-_133459508 0.963 NM_001204824
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr12_+_101988746 0.963 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr12_+_6949374 0.960 NM_002075
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chrM_-_379 0.948


chr12_-_89745997 0.940 DUSP6
dual specificity phosphatase 6
chr4_+_110749149 0.926 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr15_+_58430394 0.924 NM_020980
AQP9
aquaporin 9
chr18_-_13915534 0.915 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr2_-_74570533 0.912 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr12_-_53242716 0.902 NM_173352
KRT78
keratin 78
chr16_+_27341305 0.896 IL4R
interleukin 4 receptor
chr19_+_42580333 0.869 ZNF574
zinc finger protein 574
chr1_+_61547388 0.867 NM_001145512
NFIA
nuclear factor I/A
chr4_-_39033981 0.855 NM_024943
TMEM156
transmembrane protein 156
chr6_+_163984574 0.855 QKI
QKI, KH domain containing, RNA binding
chr9_+_103340335 0.855 NM_001018116
MURC
muscle-related coiled-coil protein
chr2_-_200325200 0.853 SATB2
SATB homeobox 2
chr11_-_116663106 0.844 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr11_+_69467210 0.839 CCND1
cyclin D1
chr19_-_43032525 0.827 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr19_+_39971051 0.823 NM_001001563
TIMM50
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr12_+_50869531 0.818 LARP4
La ribonucleoprotein domain family, member 4
chr10_+_114154522 0.818 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_63277191 0.798 NM_001199770
OTX1
orthodenticle homeobox 1
chr1_+_153330329 0.792 NM_002965
S100A9
S100 calcium binding protein A9
chr4_+_40337389 0.790 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr20_-_62611308 0.781 SAMD10
sterile alpha motif domain containing 10
chr21_-_15918635 0.775 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_35484054 0.764 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr7_+_28530747 0.762 CREB5
cAMP responsive element binding protein 5
chr1_+_101702561 0.760 S1PR1
sphingosine-1-phosphate receptor 1
chr7_-_150721551 0.757 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chrX_+_64708614 0.748 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr15_-_40633122 0.736 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr2_+_39893021 0.735 NM_152390
TMEM178
transmembrane protein 178
chr15_+_40509628 0.733 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr1_+_151611331 0.733 SNX27
sorting nexin family member 27
chr9_+_125137600 0.733 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr22_+_22676814 0.724


chr6_+_4890225 0.713 NM_001143971
CDYL
chromodomain protein, Y-like
chr2_+_234580504 0.710 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr17_-_37350051 0.707 CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr3_-_47098906 0.701 SETD2
SET domain containing 2
chr3_+_44692500 0.696 ZNF35
zinc finger protein 35
chr3_+_158787040 0.689 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr10_-_5045967 0.688 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr16_-_55866972 0.686 CES1
carboxylesterase 1
chr7_-_128415843 0.681 NM_001708
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr9_+_38392658 0.680 NM_000692
ALDH1B1
aldehyde dehydrogenase 1 family, member B1
chr11_-_102668892 0.676 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr9_-_71590754 0.674


chrM_+_10704 0.653


chr4_+_95376396 0.651 PDLIM5
PDZ and LIM domain 5
chr10_+_124030820 0.651 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr9_-_104198045 0.647 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr12_-_50616425 0.646 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_+_7107799 0.645 NM_001168344
RREB1
ras responsive element binding protein 1
chr11_-_67141008 0.644 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr7_+_5013618 0.635 RNF216P1
ring finger protein 216 pseudogene 1
chr17_-_38859976 0.629 NM_019016
KRT24
keratin 24
chrX_+_53123211 0.628 LOC100132984
uncharacterized LOC100132984
chr9_+_38392696 0.628 ALDH1B1
aldehyde dehydrogenase 1 family, member B1
chr17_-_39280377 0.625 NM_031854
KRTAP4-12
keratin associated protein 4-12
chr19_+_45349392 0.624 NM_001042724
NM_002856
PVRL2

poliovirus receptor-related 2 (herpesvirus entry mediator B)

chr16_+_22524843 0.623 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr20_+_4702499 0.621 NM_012409
PRND
prion protein 2 (dublet)
chr1_-_39347258 0.619 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP readthrough
gap junction protein, alpha 9, 59kDa
chr9_+_125132823 0.617 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr18_+_33234532 0.614 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr9_+_125132785 0.606 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_+_112890999 0.602 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr11_-_102962903 0.600 NM_032299
DCUN1D5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chrM_+_11427 0.599


chr10_+_5005453 0.599 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr9_+_131445933 0.591 NM_001122821
SET
SET nuclear oncogene
chr8_+_39771327 0.591 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr16_-_75282137 0.591 NM_001170719
BCAR1
breast cancer anti-estrogen resistance 1
chr4_-_159644439 0.582 NM_005038
PPID
peptidylprolyl isomerase D
chr2_-_217560247 0.581 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr14_+_21510384 0.579 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr12_-_11175169 0.579 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr9_+_38392700 0.573 ALDH1B1
aldehyde dehydrogenase 1 family, member B1
chr7_+_129269916 0.570 NM_001040110
NRF1
nuclear respiratory factor 1
chr10_-_101690655 0.565 DNMBP
dynamin binding protein
chr1_-_28520379 0.565 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr13_-_99910548 0.564 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chrX_+_41548225 0.562 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr19_+_42580275 0.561 NM_022752
ZNF574
zinc finger protein 574
chr16_+_4545858 0.559 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr11_+_101983170 0.558 NM_001195045
YAP1
Yes-associated protein 1
chr6_-_30899926 0.552 NM_205854
SFTA2
surfactant associated 2
chr10_-_124605690 0.552 NM_022034
CUZD1
CUB and zona pellucida-like domains 1
chr12_-_52761254 0.551 NM_002283
KRT85
keratin 85
chr21_+_45209448 0.550 RRP1
ribosomal RNA processing 1 homolog (S. cerevisiae)
chr5_+_70944968 0.543 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr19_-_5838740 0.537 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr5_-_148442606 0.536 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr17_-_48207113 0.536 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr2_+_234545099 0.535 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr11_+_36317724 0.533 NM_001160167
PRR5L
proline rich 5 like
chr6_-_138893666 0.531 NM_020464
NHSL1
NHS-like 1
chr11_+_61717355 0.530 NM_001139443
NM_004183
BEST1

bestrophin 1

chr1_-_109849613 0.530 NM_001010985
MYBPHL
myosin binding protein H-like
chr11_+_112047088 0.530 NM_001037290
BCO2
beta-carotene oxygenase 2
chr12_-_49449106 0.530 NM_003482
MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chr2_-_89513056 0.530 IGKC
immunoglobulin kappa constant
chr10_+_28878666 0.529 WAC
WW domain containing adaptor with coiled-coil
chr2_-_96947640 0.529 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr22_+_32753853 0.529 NM_001098535
RFPL3
ret finger protein-like 3
chrX_-_110655384 0.527 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr10_+_5005601 0.526 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_156863522 0.526 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr16_-_90076528 0.526 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr1_+_24834083 0.523 NM_001251978
RCAN3
RCAN family member 3
chr2_-_183387063 0.522 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr12_+_110205816 0.521 C12orf34
chromosome 12 open reading frame 34
chr19_+_54376975 0.520 MYADM
myeloid-associated differentiation marker
chr5_+_43609261 0.520 NNT
nicotinamide nucleotide transhydrogenase
chr2_+_211342405 0.509 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr13_-_46756291 0.500 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_89619820 0.494 IGKC
immunoglobulin kappa constant
chr10_-_118680978 0.493 KIAA1598
KIAA1598
chr20_-_3762060 0.493 NM_015417
SPEF1
sperm flagellar 1
chr3_-_61728810 0.490


chrX_+_110339374 0.488 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr9_+_4839763 0.487 RCL1
RNA terminal phosphate cyclase-like 1
chr1_-_156786500 0.485 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr12_+_72332625 0.483 NM_173353
TPH2
tryptophan hydroxylase 2
chr12_+_56915587 0.483 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_+_161195832 0.483 NM_032174
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr2_+_228356287 0.481 AGFG1
ArfGAP with FG repeats 1
chr8_-_38205652 0.480 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr5_+_36608430 0.476 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_-_23540770 0.475 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chrM_+_2211 0.474


chr19_-_633526 0.473 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr5_+_132432880 0.472 HSPA4
heat shock 70kDa protein 4
chrX_-_80457440 0.472 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr15_-_75194542 0.472 C15orf17
chromosome 15 open reading frame 17
chr22_-_36681757 0.469 MYH9
myosin, heavy chain 9, non-muscle
chr1_+_27648746 0.468 LOC644961
TMEM222
actin, beta pseudogene
transmembrane protein 222
chrM_+_9725 0.468


chr12_+_53645369 0.463 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr16_-_31076408 0.461 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr7_+_116660263 0.461 ST7
suppression of tumorigenicity 7
chr2_-_55237255 0.460 NM_007008
RTN4
reticulon 4

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.