Motif ID: BACH2.p2

Z-value: 1.072


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BACH2hg19_v1_chr6_-_91006580_910066440.449.5e-05Click!


Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_36019194 11.478 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr11_+_12308446 9.831 NM_032867
MICALCL
MICAL C-terminal like
chr12_+_56075329 8.566 NM_152637
METTL7B
methyltransferase like 7B
chr1_-_95007139 8.207 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr5_+_147582338 7.510 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr12_-_58159386 7.101 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_2950593 6.961 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr12_+_56075418 6.581 METTL7B
methyltransferase like 7B
chr11_-_65667809 6.516 FOSL1
FOS-like antigen 1
chr1_+_153003677 6.349 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_-_51523272 6.217 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr5_-_90610218 6.150 LOC100505994
uncharacterized LOC100505994
chr11_-_65667858 6.122 FOSL1
FOS-like antigen 1
chr3_+_11178778 6.019 NM_001098213
HRH1
histamine receptor H1
chr1_+_27719151 5.846 NM_005281
GPR3
G protein-coupled receptor 3
chr15_-_80263460 5.365 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr11_-_102668822 5.286 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr16_+_89988416 5.285 NM_001197181
TUBB3
tubulin, beta 3 class III
chr11_-_118134956 5.211 MPZL2
myelin protein zero-like 2
chr17_+_74381419 5.055 SPHK1
sphingosine kinase 1
chr1_-_153085963 4.984 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr11_-_67141647 4.963 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr17_+_74381186 4.737 NM_001142602
SPHK1
sphingosine kinase 1
chr1_-_156675237 4.647 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr11_-_118134868 4.633


chr20_-_1309809 4.624 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr11_-_118134986 4.501 MPZL2
myelin protein zero-like 2
chr14_-_101036130 4.487 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr7_+_48128225 4.462 NM_181597
UPP1
uridine phosphorylase 1
chr20_-_1309782 4.407 SDCBP2
syndecan binding protein (syntenin) 2
chr19_+_7953380 4.298 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr11_-_118135197 4.245 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr6_-_159239254 4.191 EZR
ezrin
chr19_-_35981345 4.173 NM_001244847
NM_207392
KRTDAP

keratinocyte differentiation-associated protein

chr12_+_7023490 4.088 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr18_+_61637262 4.050 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr14_+_103801160 3.936 NM_183004
EIF5
eukaryotic translation initiation factor 5
chr16_-_75301950 3.871 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr11_-_65667860 3.834 NM_005438
FOSL1
FOS-like antigen 1
chr2_+_113875469 3.796 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr1_+_153190059 3.774 NM_001195571
PRR9
proline rich 9
chr22_+_45072936 3.750 PRR5
proline rich 5 (renal)
chr9_+_140135698 3.735 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr6_-_159239198 3.701 EZR
ezrin
chr19_-_44174497 3.672 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr17_+_75372164 3.662 NM_001113494
SEPT9
septin 9
chr16_-_2908105 3.640 NM_022119
PRSS22
protease, serine, 22
chr4_+_84457390 3.637 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr17_+_74380943 3.616 SPHK1
sphingosine kinase 1
chr6_-_159239269 3.608 NM_003379
EZR
ezrin
chr9_+_140135738 3.591 TUBB4B
tubulin, beta 4B class IVb
chr16_+_83986826 3.551 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr6_+_44195008 3.526 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr1_+_223889253 3.503 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_+_152956563 3.492 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr1_+_161494035 3.464 NM_002155
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr11_-_102714240 3.441 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_-_33814757 3.420 NM_001195790
SLFN12L
schlafen family member 12-like
chr19_-_3969734 3.409 NM_001348
DAPK3
death-associated protein kinase 3
chr1_+_36621751 3.402 NM_018067
MAP7D1
MAP7 domain containing 1
chr4_+_84457256 3.375 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr7_-_102985068 3.321 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr16_-_12010518 3.305 NM_001130007
GSPT1
G1 to S phase transition 1
chr19_-_44174271 3.195 PLAUR
plasminogen activator, urokinase receptor
chr17_-_39538635 3.116 NM_021013
KRT34
keratin 34
chr8_-_133459508 3.108 NM_001204824
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr1_+_36621457 3.053 MAP7D1
MAP7 domain containing 1
chr2_+_87755059 3.050 LINC00152
long intergenic non-protein coding RNA 152
chr2_+_87754991 3.013 LINC00152
long intergenic non-protein coding RNA 152
chr2_-_65593866 2.972 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr7_+_143078457 2.970 ZYX
zyxin
chr18_+_61144143 2.969 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr12_-_48152180 2.960 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr15_+_44829332 2.953 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr15_+_44829265 2.947 NM_003758
EIF3J
eukaryotic translation initiation factor 3, subunit J
chr12_-_70083055 2.932 NM_152439
BEST3
bestrophin 3
chr11_-_65430545 2.914


chr15_-_101459410 2.906


chr1_+_901876 2.901 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr7_+_143078447 2.884 ZYX
zyxin
chr15_+_44829300 2.881 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr3_-_178977678 2.837 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr7_+_143078444 2.833 ZYX
zyxin
chr16_-_75272979 2.816 NM_001170721
BCAR1
breast cancer anti-estrogen resistance 1
chr1_+_247579457 2.814 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr1_-_153029987 2.793 NM_005988
SPRR2A
small proline-rich protein 2A
chr8_-_42065193 2.767 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr15_+_44829373 2.754 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr17_+_21188021 2.750 MAP2K3
mitogen-activated protein kinase kinase 3
chr12_-_48152860 2.750 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr2_-_65593763 2.749 SPRED2
sprouty-related, EVH1 domain containing 2
chr2_-_224866616 2.733 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_+_143078399 2.711 ZYX
zyxin
chr1_+_15256295 2.693 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr7_+_143078395 2.652 ZYX
zyxin
chr13_-_45048436 2.637 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr9_+_140119643 2.632 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr2_-_219858120 2.632 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr8_+_26150731 2.618 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr5_+_72143929 2.556 NM_153188
TNPO1
transportin 1
chr14_-_24711538 2.556 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr22_+_42372763 2.555 NM_019106
NM_145733
SEPT3

septin 3

chr17_-_33390676 2.555 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_-_209824641 2.539 NM_001017402
LAMB3
laminin, beta 3
chr14_-_61190458 2.539 NM_017420
SIX4
SIX homeobox 4
chr14_-_24777160 2.534 CIDEB
cell death-inducing DFFA-like effector b
chr9_+_140135742 2.534 TUBB4B
tubulin, beta 4B class IVb
chr14_+_103800678 2.522 EIF5
eukaryotic translation initiation factor 5
chr10_+_121410751 2.516 NM_004281
BAG3
BCL2-associated athanogene 3
chr5_+_147648374 2.513 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr1_-_935352 2.503 HES4
hairy and enhancer of split 4 (Drosophila)
chr12_-_133532847 2.497 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr9_+_140172273 2.485 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr7_+_143078358 2.485 NM_001010972
NM_003461
ZYX

zyxin

chr1_-_223853359 2.481 CAPN8
calpain 8
chr6_-_31704304 2.479 CLIC1
chloride intracellular channel 1
chr14_-_24777064 2.478


chr7_+_1577118 2.450 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr7_+_1126442 2.443 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr6_-_31704272 2.431 CLIC1
chloride intracellular channel 1
chrX_+_75392763 2.427 NM_016500
CXorf26
chromosome X open reading frame 26
chr10_-_121602030 2.418 MCMBP
minichromosome maintenance complex binding protein
chr6_-_31704281 2.408 CLIC1
chloride intracellular channel 1
chr19_-_51472816 2.397 NM_002774
KLK6
kallikrein-related peptidase 6
chr6_-_31704318 2.394 NM_001288
CLIC1
chloride intracellular channel 1
chr11_-_796175 2.386 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr16_+_4430878 2.371 VASN
vasorin
chr6_-_31704287 2.369 CLIC1
chloride intracellular channel 1
chr14_-_24777184 2.352 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_26606621 2.351 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr7_+_143058794 2.347 ZYX
zyxin
chr10_+_121410936 2.341 BAG3
BCL2-associated athanogene 3
chr1_-_6551759 2.326 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_26606586 2.314 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr19_-_39264144 2.309 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr14_-_24777153 2.303 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_183155361 2.299 LAMC2
laminin, gamma 2
chr10_+_121411042 2.274 BAG3
BCL2-associated athanogene 3
chrX_+_12993224 2.243 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr16_+_2083264 2.234 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chr10_+_121411086 2.231 BAG3
BCL2-associated athanogene 3
chr19_+_39279849 2.228 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr17_+_30677138 2.224 NM_001032293
NM_001098507
NM_003457
ZNF207


zinc finger protein 207


chr3_-_12800739 2.186 NM_018306
TMEM40
transmembrane protein 40
chr12_-_25801487 2.178 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr1_+_152974222 2.148 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr12_+_112924284 2.097 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr2_-_73316782 2.091 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr1_-_153067000 2.088 NM_001024209
SPRR2E
small proline-rich protein 2E
chr17_+_21187967 2.087 NM_145109
MAP2K3
mitogen-activated protein kinase kinase 3
chr9_-_34662629 2.076 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr2_+_135596185 2.073 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr6_-_31704070 2.066 CLIC1
chloride intracellular channel 1
chr9_+_686640 2.021


chr1_-_223853400 2.009 NM_001143962
CAPN8
calpain 8
chr6_-_31704093 2.008 CLIC1
chloride intracellular channel 1
chr2_+_48541767 1.998 NM_002158
FOXN2
forkhead box N2
chr8_+_120220554 1.995 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_-_153521717 1.979 NM_002960
S100A3
S100 calcium binding protein A3
chr1_+_32043745 1.975 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr15_-_40630272 1.970 C15orf52
chromosome 15 open reading frame 52
chr16_+_56642477 1.956 NM_005953
MT2A
metallothionein 2A
chr11_+_101983170 1.954 NM_001195045
YAP1
Yes-associated protein 1
chr2_+_207630310 1.952 FASTKD2
FAST kinase domains 2
chr1_-_28520379 1.952 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr17_+_75315590 1.948 NM_006640
SEPT9
septin 9
chr10_+_121410891 1.944 BAG3
BCL2-associated athanogene 3
chr1_+_183155393 1.938 LAMC2
laminin, gamma 2
chr16_-_74734687 1.925 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr17_+_75315632 1.898 SEPT9
septin 9
chr17_+_30677178 1.896 ZNF207
zinc finger protein 207
chr2_+_69201704 1.894 NM_019617
GKN1
gastrokine 1
chr3_+_184038050 1.890 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr9_-_130341265 1.888 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr1_+_150480584 1.878 ECM1
extracellular matrix protein 1
chr17_+_21188032 1.857 MAP2K3
mitogen-activated protein kinase kinase 3
chr10_+_121411071 1.844 BAG3
BCL2-associated athanogene 3
chr17_-_73775822 1.832 NM_005324
H3F3B
H3 histone, family 3B (H3.3B)
chr17_-_39216343 1.827 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr6_+_47666288 1.819 NM_153838
GPR115
G protein-coupled receptor 115
chr5_-_175843531 1.801 NM_001834
NM_007097
CLTB

clathrin, light chain B

chr1_+_27189628 1.797 NM_006142
SFN
stratifin
chr1_+_150480486 1.796 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr11_-_66103874 1.790 NM_004292
RIN1
Ras and Rab interactor 1
chr1_+_35246789 1.788 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr17_+_21191347 1.782 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr12_-_58165877 1.781 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr15_-_55880508 1.773 PYGO1
pygopus homolog 1 (Drosophila)
chr17_-_38911524 1.770 NM_181534
KRT25
keratin 25
chr1_+_36554452 1.754 NM_017825
ADPRHL2
ADP-ribosylhydrolase like 2
chr1_+_40627055 1.751 RLF
rearranged L-myc fusion
chr11_-_33744497 1.750 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr17_+_75446612 1.746 NM_001113496
SEPT9
septin 9
chr22_+_31478845 1.743 NM_001207017
SMTN
smoothelin
chr3_+_38388295 1.742 XYLB
xylulokinase homolog (H. influenzae)
chr3_-_196065191 1.737 TM4SF19
transmembrane 4 L six family member 19
chr16_+_22308722 1.727 NM_018119
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr1_+_183155173 1.698 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chrX_-_154563735 1.688 NM_001289
CLIC2
chloride intracellular channel 2
chr9_+_99691285 1.686 NM_001045477
NM_001170741
FAM22G

family with sequence similarity 22, member G


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.65 2.41e-06 GO:0008544 epidermis development
2.85 5.51e-04 GO:0009888 tissue development
13.16 8.33e-04 GO:0031424 keratinization
3.22 2.45e-03 GO:0050878 regulation of body fluid levels
2.53 1.27e-02 GO:0009611 response to wounding
2.95 1.50e-02 GO:0042060 wound healing
8.64 1.52e-02 GO:0030216 keratinocyte differentiation
3.15 1.76e-02 GO:0007599 hemostasis
7.47 3.95e-02 GO:0009913 epidermal cell differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
22.55 2.91e-05 GO:0001533 cornified envelope
78.92 2.62e-02 GO:0005610 laminin-5 complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
6.35 2.32e-02 GO:0004867 serine-type endopeptidase inhibitor activity
2.61 2.71e-02 GO:0005198 structural molecule activity