Motif ID: ATF6.p2

Z-value: 0.939


Transcription factors associated with ATF6.p2:

Gene SymbolEntrez IDGene Name
ATF6 22926 activating transcription factor 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF6hg19_v1_chr1_+_161736122_1617361500.181.2e-01Click!


Activity profile for motif ATF6.p2.

activity profile for motif ATF6.p2


Sorted Z-values histogram for motif ATF6.p2

Sorted Z-values for motif ATF6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_6772705 6.500 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr19_+_6772801 5.515


chr2_+_75061234 5.274 HK2
hexokinase 2
chr6_+_151561094 4.698 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr3_-_73673978 4.302 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr19_+_16187306 3.444 TPM4
tropomyosin 4
chr19_+_16187266 3.263 TPM4
tropomyosin 4
chr19_+_16187315 3.217 TPM4
tropomyosin 4
chr5_+_159656436 3.141 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr2_-_224467049 2.941 SCG2
secretogranin II
chr2_-_224467095 2.719 SCG2
secretogranin II
chr8_-_29207795 2.689 NM_001394
DUSP4
dual specificity phosphatase 4
chr17_-_46703613 2.634 NM_024017
HOXB9
homeobox B9
chr1_+_9599520 2.629 NM_032315
SLC25A33
solute carrier family 25, member 33
chr12_-_49318663 2.584 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr19_+_16187047 2.522 NM_003290
TPM4
tropomyosin 4
chr12_+_72148653 2.494 NM_014999
RAB21
RAB21, member RAS oncogene family
chr1_+_9599546 2.457 SLC25A33
solute carrier family 25, member 33
chr9_-_79520878 2.452 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr3_-_119182423 2.429 NM_018266
TMEM39A
transmembrane protein 39A
chr10_+_112257624 2.384 NM_004419
DUSP5
dual specificity phosphatase 5
chr22_+_35777051 2.345 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr17_-_13505217 2.297 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr7_-_2354050 2.276 NM_013321
SNX8
sorting nexin 8
chr7_-_2354010 2.275 SNX8
sorting nexin 8
chrX_+_118108575 2.267 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr7_-_100808832 2.254 NM_003378
VGF
VGF nerve growth factor inducible
chr19_+_49468656 2.208 FTL
ferritin, light polypeptide
chr22_+_35777087 2.197 HMOX1
heme oxygenase (decycling) 1
chr1_+_26496382 2.182 NM_015871
ZNF593
zinc finger protein 593
chr14_-_61190458 2.131 NM_017420
SIX4
SIX homeobox 4
chr19_+_49468587 2.040 FTL
ferritin, light polypeptide
chr4_+_75310852 1.974 NM_001657
AREG
amphiregulin
chr9_-_140353785 1.973 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr11_-_118927756 1.911 HYOU1
hypoxia up-regulated 1
chr7_-_27224762 1.841 NM_005523
HOXA11
homeobox A11
chr10_+_70847857 1.836 SRGN
serglycin
chr19_+_49468557 1.821 NM_000146
FTL
ferritin, light polypeptide
chrX_+_118108595 1.819 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr1_-_212873306 1.816 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr9_-_140353748 1.809 NELF
nasal embryonic LHRH factor
chr17_-_46688362 1.809 NM_004502
HOXB7
homeobox B7
chr11_-_118927872 1.793 NM_006389
NM_001130991
HYOU1

hypoxia up-regulated 1

chr14_-_38064440 1.784 NM_004496
FOXA1
forkhead box A1
chr11_-_118927851 1.758 HYOU1
hypoxia up-regulated 1
chr5_-_141704468 1.728 SPRY4
sprouty homolog 4 (Drosophila)
chr19_+_49458031 1.725 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr11_-_118927833 1.717 HYOU1
hypoxia up-regulated 1
chr10_-_128077072 1.715 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr11_-_118927815 1.700 HYOU1
hypoxia up-regulated 1
chr9_+_102584136 1.691 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr17_+_49337882 1.658 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr11_-_2018703 1.657 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr11_+_73087396 1.649 NM_152222
RELT
RELT tumor necrosis factor receptor
chr3_-_75484091 1.638 FAM86DP
family with sequence similarity 86, member D, pseudogene
chr19_-_44100127 1.629 NM_001007561
IRGQ
immunity-related GTPase family, Q
chr19_-_48018163 1.628 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr9_+_79074067 1.602 NM_001097633
NM_001490
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr17_+_49337892 1.597 NM_016001
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr1_+_26758772 1.575 NM_001243564
NM_001243565
NM_024887
NM_205861
DHDDS



dehydrodolichyl diphosphate synthase



chr12_-_48152180 1.565 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr4_-_119757288 1.556 NM_014822
SEC24D
SEC24 family, member D (S. cerevisiae)
chr4_-_119757183 1.556 SEC24D
SEC24 family, member D (S. cerevisiae)
chr20_-_22564893 1.537 FOXA2
forkhead box A2
chr17_+_49337909 1.533 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr1_+_948846 1.528 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr12_+_122150638 1.484 NM_001080825
TMEM120B
transmembrane protein 120B
chr7_+_5632435 1.482 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr9_+_35538890 1.476 RUSC2
RUN and SH3 domain containing 2
chr12_+_72148909 1.471 RAB21
RAB21, member RAS oncogene family
chr1_-_212873197 1.458 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr19_+_49458129 1.424 BAX
BCL2-associated X protein
chr5_-_141704575 1.419 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr8_-_9009050 1.411 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr10_+_70847817 1.410 NM_002727
SRGN
serglycin
chr9_+_35538628 1.397 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr11_+_69455837 1.392 NM_053056
CCND1
cyclin D1
chr11_+_69455884 1.387 CCND1
cyclin D1
chr11_+_69455938 1.375 CCND1
cyclin D1
chr11_+_128563772 1.373 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr3_+_171757442 1.364 FNDC3B
fibronectin type III domain containing 3B
chr9_+_100818941 1.363 NM_018946
NANS
N-acetylneuraminic acid synthase
chr10_-_128077011 1.348 ADAM12
ADAM metallopeptidase domain 12
chr3_-_129830320 1.348


chr1_-_156786500 1.340 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr19_-_4670375 1.334 NM_019107
C19orf10
chromosome 19 open reading frame 10
chr14_+_103388992 1.333 NM_030943
AMN
amnionless homolog (mouse)
chr1_-_113498828 1.330 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr22_+_38597938 1.324 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr11_-_67888670 1.316 CHKA
choline kinase alpha
chr12_-_49319211 1.310 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr3_+_171757432 1.310 FNDC3B
fibronectin type III domain containing 3B
chr12_-_76425375 1.307 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr8_+_120220554 1.301 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr3_-_127541160 1.301 NM_007283
MGLL
monoglyceride lipase
chr19_-_55628780 1.292 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr17_-_48474870 1.283 LRRC59
leucine rich repeat containing 59
chr3_-_129830273 1.280


chr19_+_58962954 1.267 NM_207395
ZNF324B
zinc finger protein 324B
chr17_-_48474678 1.258 LRRC59
leucine rich repeat containing 59
chr17_-_48474910 1.253 NM_018509
LRRC59
leucine rich repeat containing 59
chr19_-_48018317 1.240 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr4_-_99850242 1.230 NM_001130678
EIF4E
eukaryotic translation initiation factor 4E
chr7_+_5632453 1.219 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chrX_+_55744049 1.210 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr17_-_48474864 1.204 LRRC59
leucine rich repeat containing 59
chr17_-_8151353 1.203 CTC1
CTS telomere maintenance complex component 1
chr4_-_89205887 1.196 NM_152542
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr20_-_44420538 1.191 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr4_-_99850280 1.184 EIF4E
eukaryotic translation initiation factor 4E
chr9_-_101984233 1.177 NM_033087
ALG2
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
chr8_+_57124321 1.168 CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr7_-_30066124 1.164 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr6_+_138483024 1.153 NM_020340
KIAA1244
KIAA1244
chr19_-_4670332 1.152 C19orf10
chromosome 19 open reading frame 10
chr11_+_73087670 1.149 NM_032871
RELT
RELT tumor necrosis factor receptor
chr16_-_5147739 1.137 NM_201400
NM_201598
FAM86A

family with sequence similarity 86, member A

chr19_+_38810461 1.124 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr19_+_49458151 1.119 BAX
BCL2-associated X protein
chr4_+_128982404 1.119 LARP1B
La ribonucleoprotein domain family, member 1B
chr11_+_128563993 1.102 FLI1
Friend leukemia virus integration 1
chr1_+_27719151 1.099 NM_005281
GPR3
G protein-coupled receptor 3
chr19_-_55895602 1.093 NM_001190764
TMEM238
transmembrane protein 238
chr8_-_75233461 1.092 NM_020647
JPH1
junctophilin 1
chr18_+_10526095 1.087 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr1_+_85527992 1.085 NM_145172
WDR63
WD repeat domain 63
chr17_-_45928530 1.085 SP6
Sp6 transcription factor
chr6_+_37137882 1.077 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chrX_+_100663213 1.076 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr19_+_38810520 1.074 KCNK6
potassium channel, subfamily K, member 6
chr10_+_101419169 1.063 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chrX_+_100663229 1.058 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr19_+_38810751 1.056 KCNK6
potassium channel, subfamily K, member 6
chr16_+_69373414 1.056 NM_001199434
NM_016101
NIP7

nuclear import 7 homolog (S. cerevisiae)

chr6_+_30294224 1.051


chr1_-_16482426 1.049 NM_004431
EPHA2
EPH receptor A2
chr12_+_120933911 1.046 DYNLL1
dynein, light chain, LC8-type 1
chr7_+_72848108 1.042 NM_003508
FZD9
frizzled family receptor 9
chr19_+_38810540 1.041 KCNK6
potassium channel, subfamily K, member 6
chr11_+_128564130 1.040 FLI1
Friend leukemia virus integration 1
chr4_+_140222668 1.033 NM_057175
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chrX_+_100663205 1.031 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr1_-_43736600 1.029 EBNA1BP2
EBNA1 binding protein 2
chr1_-_113498615 1.029 NM_001166496
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chrX_-_118827322 1.023 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr17_-_39092714 1.022 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_224467142 1.022 NM_003469
SCG2
secretogranin II
chr3_-_150263899 1.020 SERP1
stress-associated endoplasmic reticulum protein 1
chr18_+_10526022 1.015 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr5_-_168006297 1.008 PANK3
pantothenate kinase 3
chr17_+_41132587 1.008 RUNDC1
RUN domain containing 1
chr7_+_38217919 1.005 STARD3NL
STARD3 N-terminal like
chr12_+_120933916 1.002 DYNLL1
dynein, light chain, LC8-type 1
chr18_+_10526044 1.000 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr2_+_113403433 1.000 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chrX_-_71526583 0.999 NM_004143
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr18_+_10525861 0.989 NM_003826
NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr17_+_80186886 0.986 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr15_-_101792125 0.971 NM_014918
CHSY1
chondroitin sulfate synthase 1
chr1_-_212873104 0.971 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr14_+_24600674 0.970 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr3_-_156272909 0.966 NM_007107
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr6_-_15248886 0.964


chr7_+_65338343 0.958 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr4_+_128982502 0.953 NM_018078
NM_032239
NM_178043
LARP1B


La ribonucleoprotein domain family, member 1B


chr4_+_140222620 0.944 NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr2_+_234263153 0.941 DGKD
diacylglycerol kinase, delta 130kDa
chr4_-_79860369 0.936 NM_001040202
PAQR3
progestin and adipoQ receptor family member III
chr5_+_138211084 0.936 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr17_+_41132581 0.934 NM_173079
RUNDC1
RUN domain containing 1
chr11_-_67141008 0.933 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr7_+_44646120 0.930 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr8_+_57124314 0.930 NM_001011667
NM_001011668
NM_001011669
NM_001011670
NM_001011671
NM_024300
CHCHD7





coiled-coil-helix-coiled-coil-helix domain containing 7





chrX_+_102840412 0.928 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr7_+_65338349 0.927 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chrX_-_102941582 0.923 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr1_+_29562947 0.923 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr11_+_69455978 0.922 CCND1
cyclin D1
chr19_-_48018277 0.916 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr6_-_80656870 0.913 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr12_-_117175634 0.911 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr10_-_120840241 0.911 EIF3A
eukaryotic translation initiation factor 3, subunit A
chr1_-_20812727 0.910 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr8_-_104427319 0.908 SLC25A32
solute carrier family 25, member 32
chr9_-_140353612 0.901 NELF
nasal embryonic LHRH factor
chr5_-_168006413 0.900 NM_024594
PANK3
pantothenate kinase 3
chr7_+_44646168 0.898 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr5_+_112196976 0.897 SRP19
signal recognition particle 19kDa
chr4_+_128982483 0.896 LARP1B
La ribonucleoprotein domain family, member 1B
chr5_-_89825292 0.892 NM_198273
LYSMD3
LysM, putative peptidoglycan-binding, domain containing 3
chr14_-_38064299 0.891 FOXA1
forkhead box A1
chr13_+_38923941 0.890 NM_016617
UFM1
ubiquitin-fold modifier 1
chr16_+_88772884 0.889 NM_001012759
NM_001012762
CTU2

cytosolic thiouridylase subunit 2 homolog (S. pombe)

chr7_+_44646189 0.887 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr17_+_7761310 0.886 CYB5D1
cytochrome b5 domain containing 1
chr7_+_30810987 0.884 NM_032222
FAM188B
family with sequence similarity 188, member B
chr7_+_38217807 0.884 NM_032016
STARD3NL
STARD3 N-terminal like
chr3_-_156272868 0.880 SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr12_-_106641675 0.879 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr8_-_13134028 0.879 DLC1
deleted in liver cancer 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
20.87 2.12e-03 GO:0001704 formation of primary germ layer

Nothing significant found in compartment category.

Nothing significant found in function category.