Motif ID: ALX1.p2

Z-value: 0.770


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ALX1hg19_v1_chr12_+_85673884_856740350.661.6e-10Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_23633771 5.019 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr18_+_28898051 4.361 NM_001942
DSG1
desmoglein 1
chr18_-_61329113 3.780 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr1_+_152730505 2.760 NM_001025231
KPRP
keratinocyte proline-rich protein
chr19_+_10123861 2.557 NM_015725
RDH8
retinol dehydrogenase 8 (all-trans)
chr21_-_34787167 2.515


chr6_-_26189303 2.508 NM_003539
HIST1H4D
histone cluster 1, H4d
chrX_-_131261871 2.473 NM_194277
FRMD7
FERM domain containing 7
chr19_-_4535202 2.425 NM_001013706
PLIN5
perilipin 5
chrX_+_91090459 2.162 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr7_-_115670811 2.155 TFEC
transcription factor EC
chr4_+_70796798 2.105 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr3_+_121286777 2.099 NM_001012659
ARGFX
arginine-fifty homeobox
chrX_+_91089658 2.087 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr11_+_73661363 2.073 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr3_-_194072004 2.049 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr11_+_7618416 2.045 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_+_140625146 2.040 NM_018935
PCDHB15
protocadherin beta 15
chr11_+_55606226 1.989 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr7_-_115670774 1.934 TFEC
transcription factor EC
chrX_-_84634742 1.932 NM_024921
POF1B
premature ovarian failure, 1B
chr9_-_21368005 1.929 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr19_+_56270506 1.893 NM_001145014
RFPL4A
ret finger protein-like 4A
chr3_-_112013073 1.880 NM_183061
SLC9A10
solute carrier family 9, member 10
chr5_+_36608430 1.873 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_138718941 1.868 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr12_-_11139510 1.829 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr12_-_4488707 1.817 NM_020638
FGF23
fibroblast growth factor 23
chr5_+_140624916 1.752 PCDHB15
protocadherin beta 15
chr14_-_75330535 1.745 NM_001080408
NM_001243007
PROX2

prospero homeobox 2

chr5_+_36606667 1.708 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr20_+_43803539 1.695 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr16_+_21695749 1.692 NM_001161683
OTOA
otoancorin
chr16_+_31271327 1.684 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr11_-_7950208 1.672 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr10_-_42863435 1.615 LOC441666
zinc finger protein 91 pseudogene
chr4_-_69434215 1.607 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chrX_-_84634664 1.603 POF1B
premature ovarian failure, 1B
chr9_+_35042222 1.591 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr2_-_178787522 1.577 NM_001077358
PDE11A
phosphodiesterase 11A
chr6_+_27107060 1.566 NM_003495
HIST2H4B
HIST1H4I
histone cluster 2, H4b
histone cluster 1, H4i
chr9_-_114090712 1.562 NM_205859
OR2K2
olfactory receptor, family 2, subfamily K, member 2
chr7_-_81399286 1.536 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr19_-_21646685 1.536


chr1_+_222910557 1.533 NM_207468
FAM177B
family with sequence similarity 177, member B
chr1_+_152943127 1.530 NM_173080
SPRR4
small proline-rich protein 4
chr4_-_72669757 1.526 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr9_+_125376947 1.521 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr2_-_178973065 1.506 NM_001077197
PDE11A
phosphodiesterase 11A
chr16_+_31271277 1.486 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr5_+_140220811 1.479 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr19_+_56347943 1.475 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr19_+_39786964 1.471 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr7_-_44580857 1.459 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr16_+_31271311 1.451 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr18_-_51880942 1.441 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr8_+_7783858 1.439 NM_001193630
LOC100132396
zinc finger protein 705D-like
chrY_+_4924128 1.436 NM_032972
NM_032973
PCDH11X
PCDH11Y

protocadherin 11 X-linked
protocadherin 11 Y-linked

chr12_+_20963637 1.434 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr1_-_89641722 1.425 NM_207398
GBP7
guanylate binding protein 7
chr8_-_82395401 1.413 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_-_198906536 1.413 LOC100131234
familial acute myelogenous leukemia related factor
chr9_+_90497740 1.385 NM_178828
C9orf79
chromosome 9 open reading frame 79
chr7_-_25268057 1.379 NM_022150
NPVF
neuropeptide VF precursor
chr11_-_31014232 1.362 NM_020869
DCDC5
doublecortin domain containing 5
chr8_-_33457491 1.337 DUSP26
dual specificity phosphatase 26 (putative)
chr14_+_68168602 1.332 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr1_-_153283166 1.324 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr19_-_20150251 1.321 NM_033196
ZNF682
zinc finger protein 682
chr1_-_35370983 1.304 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chrX_+_66788682 1.302 NM_001011645
AR
androgen receptor
chr10_-_28571014 1.299 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr12_+_26348268 1.290 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr10_+_43867089 1.273 NM_001184963
NM_173160
FXYD4

FXYD domain containing ion transport regulator 4

chrX_-_49089770 1.266 NM_005183
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr5_+_57787260 1.258 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr6_+_31683084 1.236 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr2_-_130902568 1.229 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr19_-_6433772 1.216 NM_173637
SLC25A41
solute carrier family 25, member 41
chr14_+_74083547 1.208 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr2_-_77749335 1.203 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr18_+_29769986 1.202 NM_005925
MEP1B
meprin A, beta
chr4_-_120243257 1.193 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr9_+_107456659 1.189 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr19_+_21688389 1.185 NM_001001415
ZNF429
zinc finger protein 429
chr2_-_201967702 1.184


chr13_-_49018802 1.173 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr19_-_18902077 1.167 NM_000095
COMP
cartilage oligomeric matrix protein
chr11_-_85425790 1.161 NM_032379
SYTL2
synaptotagmin-like 2
chr3_+_122334461 1.150 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr9_-_27297106 1.150 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr3_-_167371288 1.149 NM_178824
WDR49
WD repeat domain 49
chr20_+_32250089 1.149 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr12_-_11184005 1.148 NM_176885
TAS2R31
taste receptor, type 2, member 31
chr18_-_56296188 1.146 NM_052947
ALPK2
alpha-kinase 2
chr3_-_9920633 1.145 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr1_-_67266930 1.139 NM_005478
INSL5
insulin-like 5
chr2_-_163008913 1.135 NM_002054
GCG
glucagon
chr19_+_21579884 1.126 NM_001076678
NM_145326
NM_175910
ZNF493


zinc finger protein 493


chr11_-_128737132 1.126 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr2_+_204571379 1.107 CD28
CD28 molecule
chr14_-_107013122 1.105 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr13_+_51915167 1.100 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr1_+_160370363 1.095 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr1_+_192127591 1.094 NM_130782
RGS18
regulator of G-protein signaling 18
chr17_-_79905108 1.092 NM_001145113
MYADML2
myeloid-associated differentiation marker-like 2
chr8_-_33457435 1.080 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chr3_+_57094468 1.077 NM_181727
SPATA12
spermatogenesis associated 12
chr17_-_34328530 1.076 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr11_-_114466397 1.066 FAM55D
family with sequence similarity 55, member D
chr21_+_42733916 1.062 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr3_-_151058439 1.059 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chrX_+_140982451 1.058 NM_177456
MAGEC3
melanoma antigen family C, 3
chr1_-_157522151 1.057 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr5_+_140247767 1.052 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr3_+_49235860 1.051 NM_178173
CCDC36
coiled-coil domain containing 36
chr4_-_74864296 1.047 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr9_-_28719302 1.047 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr11_-_64703334 1.045 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr5_+_140557370 1.042 NM_019120
PCDHB8
protocadherin beta 8
chr5_-_176326314 1.041 NM_002115
HK3
hexokinase 3 (white cell)
chr10_-_7682741 1.035 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr13_-_38172862 1.026 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_+_155853546 1.024 SYT11
synaptotagmin XI
chr2_+_204571197 1.022 NM_001243077
NM_001243078
NM_006139
CD28


CD28 molecule


chr22_-_23922376 1.014 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr2_+_131278666 1.014 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr7_+_37723378 1.011


chr12_+_21284127 1.009 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr10_-_69425356 1.007 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr19_-_23941571 1.004 NM_138286
ZNF681
zinc finger protein 681
chr19_-_14992166 1.000 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr7_-_130418859 0.997 NM_138693
KLF14
Kruppel-like factor 14
chr10_+_81892429 0.996 PLAC9
placenta-specific 9
chrX_-_6146655 0.993 NM_181332
NLGN4X
neuroligin 4, X-linked
chr6_+_46761093 0.988 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr1_-_203198772 0.986 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr16_-_72206348 0.984 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chrX_+_78003205 0.980 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr14_+_94385239 0.980 NM_001207071
NM_138344
FAM181A

family with sequence similarity 181, member A

chr9_-_107367907 0.980 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr10_-_48806862 0.978 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chrX_+_102965836 0.978 NM_182541
TMEM31
transmembrane protein 31
chr2_+_166095911 0.975 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_71248794 0.973 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr14_-_106926393 0.967 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_+_7562444 0.963 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr15_-_90222572 0.963 NM_001145311
NM_002666
PLIN1

perilipin 1

chr7_+_99425635 0.962 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr6_+_161123224 0.962 NM_000301
NM_001168338
PLG

plasminogen

chr9_+_111624545 0.955 NM_006687
ACTL7A
actin-like 7A
chrX_+_41548225 0.953 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr7_+_80267782 0.951 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr14_+_62462540 0.943 NM_031914
SYT16
synaptotagmin XVI
chr11_-_16497917 0.939 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr20_+_51801821 0.934 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr4_+_74270832 0.933 ALB
albumin
chr5_-_132200476 0.933 NM_005260
GDF9
growth differentiation factor 9
chr12_-_11463353 0.933 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr2_-_131356859 0.931 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr3_+_35683848 0.931 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_-_25150372 0.928 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr6_+_28317687 0.927 NM_001242894
NM_001242895
NM_024493
ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr9_-_117444368 0.924 NM_001199233
LOC100505478
uncharacterized LOC100505478
chr10_+_81892497 0.923 PLAC9
placenta-specific 9
chr12_+_15699544 0.922 PTPRO
protein tyrosine phosphatase, receptor type, O
chr6_+_153019029 0.921 NM_025107
MYCT1
myc target 1
chr19_+_54466289 0.917 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr2_+_226265601 0.912 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr7_+_22766765 0.912 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr17_-_34328607 0.909 CCL14-CCL15
CCL14-CCL15 readthrough
chr1_-_178840079 0.909 NM_004673
ANGPTL1
angiopoietin-like 1
chr7_+_102023016 0.908


chr4_-_69536314 0.905 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr18_-_70532933 0.904 NM_138999
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr6_+_47624222 0.901 NM_153839
GPR111
G protein-coupled receptor 111
chr15_-_65398578 0.899 NM_001163692
UBAP1L
ubiquitin associated protein 1-like
chr13_+_108922205 0.895 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr14_-_106552313 0.876 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_-_114466471 0.867 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr18_+_32335939 0.859 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chrX_-_2886285 0.857 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr11_-_6790187 0.857 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr19_+_827821 0.851 NM_001700
AZU1
azurocidin 1
chr2_+_103089761 0.851 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr12_-_11508509 0.846 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr2_-_89165652 0.845


chr5_-_22853730 0.844 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr7_-_115670828 0.833 NM_001018058
NM_012252
TFEC

transcription factor EC

chr22_+_25202135 0.832 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1



chr12_-_10022457 0.812 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr12_-_11548485 0.807 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr6_-_169650846 0.806


chr12_+_10034087 0.806 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr7_-_102283237 0.804 NM_001114403
UPK3BL
uroplakin 3B-like
chr12_+_54891522 0.792 NCKAP1L
NCK-associated protein 1-like
chr18_-_3845295 0.791 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr5_+_147582338 0.791 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr8_-_86290333 0.791 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr11_-_117748200 0.789 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.26 1.86e-03 GO:0005576 extracellular region
1.68 9.92e-03 GO:0071944 cell periphery
1.66 1.62e-02 GO:0005886 plasma membrane
1.96 4.07e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.