Motif ID: AIRE.p2

Z-value: 0.624


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
AIREhg19_v1_chr21_+_45705720_45705769-0.028.8e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_4692226 3.134 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr2_+_29038862 3.039 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr10_+_123748688 2.922 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr4_+_159442865 2.799 NM_001253727
NM_001253728
NM_001253729
NM_001253730
NM_001253732
NM_001253733
NM_021634
RXFP1






relaxin/insulin-like family peptide receptor 1






chr12_-_53600999 2.511 NM_000889
ITGB7
integrin, beta 7
chr12_+_101988746 2.406 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr15_+_58430394 2.178 NM_020980
AQP9
aquaporin 9
chr18_-_61329113 1.841 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr19_-_14939275 1.803 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr12_-_10282680 1.650 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_+_161185084 1.563 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr12_-_371994 1.522 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chr13_+_31309644 1.501 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chrX_-_2882288 1.491 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chrX_-_110513665 1.487 CAPN6
calpain 6
chr5_+_176811431 1.480 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr1_+_181002560 1.456 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr19_-_58892382 1.427 NM_001129730
NM_138466
ZNF837

zinc finger protein 837

chr15_-_99789585 1.408 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr11_+_112832089 1.396 NCAM1
neural cell adhesion molecule 1
chr22_+_36649172 1.307 APOL1
apolipoprotein L, 1
chr19_-_49220213 1.291 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr22_+_36649116 1.248 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr7_+_112120907 1.237 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr5_+_118965253 1.231 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr10_-_94003002 1.215 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chrX_+_83116153 1.205 NM_021118
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr7_+_1609730 1.197 KIAA1908
uncharacterized LOC114796
chr16_+_10522724 1.153 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr19_-_49865638 1.099 NM_003598
TEAD2
TEA domain family member 2
chr17_-_34207308 1.058 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr12_+_51318743 1.055 METTL7A
methyltransferase like 7A
chr18_-_47814691 1.048 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr19_-_48752921 1.033 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr1_+_161185061 1.028 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr2_-_198540583 1.027 NM_144629
RFTN2
raftlin family member 2
chr6_+_32132379 1.009 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr6_+_119215240 1.004 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr6_+_35226685 1.001 ZNF76
zinc finger protein 76
chr2_-_122042767 0.971 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr4_-_39033981 0.962 NM_024943
TMEM156
transmembrane protein 156
chr19_-_6670078 0.950 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr12_-_57693146 0.941


chr7_-_64023454 0.926 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr6_-_99849266 0.885 PNISR
PNN-interacting serine/arginine-rich protein
chr14_+_39734475 0.885 NM_203354
CTAGE5
CTAGE family, member 5
chr19_+_21264952 0.880 NM_182515
ZNF714
zinc finger protein 714
chr13_-_36429798 0.867 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr19_-_55628780 0.866 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr13_+_31309690 0.863 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_-_64467006 0.860 NM_001007253
ERV3-1
endogenous retrovirus group 3, member 1
chrM_+_9182 0.858


chr19_-_39826676 0.853 NM_004877
GMFG
glia maturation factor, gamma
chr19_+_47813074 0.852 NM_001736
C5AR1
complement component 5a receptor 1
chr6_-_26189303 0.852 NM_003539
HIST1H4D
histone cluster 1, H4d
chr19_+_18208596 0.834 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr1_+_43282775 0.822 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chrM_+_9217 0.822


chr19_-_48759141 0.819 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr2_+_152214105 0.809 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr16_-_28621279 0.776 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr2_+_11680079 0.770 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr20_-_34195409 0.765 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr10_+_5005453 0.748 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_-_101767714 0.745 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr1_+_151009028 0.727 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chr16_-_1494489 0.726 NM_001143980
CCDC154
coiled-coil domain containing 154
chrX_-_100307042 0.723 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chrM_+_8857 0.708


chr2_-_32490688 0.707 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr6_+_29759682 0.696 NM_001207043
LOC554223
histocompatibility antigen-related
chr19_-_23869939 0.694 NM_138330
ZNF675
zinc finger protein 675
chrX_-_100307091 0.693 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr19_-_10613767 0.691 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr10_-_43187174 0.690


chr15_-_41166336 0.678 NM_133639
RHOV
ras homolog gene family, member V
chr1_+_28764660 0.676 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr11_-_62439085 0.674 C11orf48
chromosome 11 open reading frame 48
chr18_-_61311465 0.672 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr4_+_87968191 0.663 AFF1
AF4/FMR2 family, member 1
chr7_+_2598712 0.656 IQCE
IQ motif containing E
chr5_+_173472692 0.642 NM_015980
HMP19
HMP19 protein
chr12_+_55248298 0.640 NM_058173
MUCL1
mucin-like 1
chr4_+_15704752 0.638 BST1
bone marrow stromal cell antigen 1
chr4_-_139163222 0.638 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr6_+_31973358 0.637 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr7_+_2598676 0.634 IQCE
IQ motif containing E
chr15_-_77154284 0.628 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr1_-_182357871 0.626 GLUL
glutamate-ammonia ligase
chr2_+_169929009 0.619 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_+_1609698 0.610 KIAA1908
uncharacterized LOC114796
chr6_-_32784727 0.607 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr16_+_2809933 0.602


chr10_+_135207607 0.591 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr14_+_95078713 0.590 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr2_-_188312872 0.588 NM_005795
CALCRL
calcitonin receptor-like
chr19_-_39926535 0.562 NM_001020
RPS16
ribosomal protein S16
chr7_-_102283237 0.551 NM_001114403
UPK3BL
uroplakin 3B-like
chr18_-_65182507 0.549 DSEL
dermatan sulfate epimerase-like
chr19_-_46285752 0.547 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr3_-_93747453 0.547 NM_001001850
STX19
syntaxin 19
chrM_-_9203 0.536


chr5_+_60933635 0.534 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr9_+_42717233 0.528 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr7_+_76109826 0.520 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr11_+_114549199 0.517 NM_182495
FAM55B
family with sequence similarity 55, member B
chr17_-_48945338 0.514 NM_001243877
TOB1
transducer of ERBB2, 1
chr10_+_5238756 0.514 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr19_+_3728373 0.499 NM_014428
TJP3
tight junction protein 3 (zona occludens 3)
chrM_+_4770 0.490


chr6_-_13295817 0.489 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr2_+_12858363 0.484


chr22_-_36556781 0.484 NM_145640
APOL3
apolipoprotein L, 3
chrX_-_100306859 0.482 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr18_+_52258389 0.479 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr1_-_161207879 0.478 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr16_+_67001377 0.477 NM_001185176
CES3
carboxylesterase 3
chr15_+_66585632 0.476 NM_133375
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr12_-_8043743 0.476 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr16_-_4817124 0.474 NM_021646
ZNF500
zinc finger protein 500
chr12_+_8332789 0.464 FAM66C
family with sequence similarity 66, member C
chr6_-_138189313 0.459


chr3_-_157217342 0.458 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr6_+_33244916 0.456 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr22_-_22089975 0.455 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr15_+_41576150 0.452 OIP5-AS1
OIP5 antisense RNA 1 (non-protein coding)
chr19_-_10614083 0.450 KEAP1
kelch-like ECH-associated protein 1
chr3_-_194119994 0.448 NM_004488
GP5
glycoprotein V (platelet)
chr16_+_66995099 0.447 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr9_-_70429730 0.447 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr20_-_42939737 0.446 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr19_+_48248792 0.446 NM_015710
GLTSCR2
glioma tumor suppressor candidate region gene 2
chr19_+_48248798 0.440 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr2_-_170430312 0.440 NM_024622
FASTKD1
FAST kinase domains 1
chr3_+_132036210 0.431 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr3_+_107096187 0.430 NM_032600
CCDC54
coiled-coil domain containing 54
chr10_-_61122219 0.429 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr19_-_39322411 0.425 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr6_-_133078894 0.422 NM_001242350
NM_004665
VNN2

vanin 2

chr16_-_787888 0.421 NARFL
nuclear prelamin A recognition factor-like
chr2_-_214015053 0.414 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr16_-_86588680 0.413 NM_001159380
NM_001159377
NM_001159378
NM_001159379
NM_022764
MTHFSD




methenyltetrahydrofolate synthetase domain containing




chr9_-_70178814 0.408 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr7_-_97601654 0.408


chr19_+_7599037 0.406 NM_006702
NM_001166112
PNPLA6

patatin-like phospholipase domain containing 6

chr12_+_51318515 0.404 NM_014033
METTL7A
methyltransferase like 7A
chr16_-_4524895 0.403 NM_020677
NMRAL1
NmrA-like family domain containing 1
chr2_+_234590583 0.395 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr5_+_173472737 0.388 HMP19
HMP19 protein
chr5_-_177207465 0.387 NM_173663
FAM153A
family with sequence similarity 153, member A
chr2_-_61245363 0.387 NM_144709
PUS10
pseudouridylate synthase 10
chr9_-_136933552 0.381 BRD3
bromodomain containing 3
chr6_-_53213747 0.377 NM_001242828
NM_001242830
NM_001242831
NM_021814
ELOVL5



ELOVL fatty acid elongase 5



chrM_+_9725 0.376


chr2_-_190927321 0.373 NM_005259
MSTN
myostatin
chr7_+_2598646 0.371 IQCE
IQ motif containing E
chr4_-_159093523 0.370 FAM198B
family with sequence similarity 198, member B
chr12_-_123187842 0.367 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr9_-_95298251 0.366 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chrM_+_4465 0.362


chr11_+_65479685 0.351 KAT5
K(lysine) acetyltransferase 5
chr19_-_8408120 0.349 NM_198471
KANK3
KN motif and ankyrin repeat domains 3
chr17_-_67138013 0.347 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_-_64578765 0.344 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr1_-_169680677 0.339 NM_000655
SELL
selectin L
chr12_-_56753856 0.338 STAT2
signal transducer and activator of transcription 2, 113kDa
chr3_+_189507448 0.335 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr3_+_29322802 0.333 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr6_+_31590468 0.333


chr15_+_66585822 0.330 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr7_+_76090971 0.329 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr1_+_210501595 0.327 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr17_+_41003184 0.326 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_56753912 0.322 STAT2
signal transducer and activator of transcription 2, 113kDa
chr3_-_186262114 0.322 NM_017541
CRYGS
crystallin, gamma S
chr6_-_42858526 0.318 NM_001008739
C6orf226
chromosome 6 open reading frame 226
chr6_+_31683084 0.318 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr6_-_31830593 0.311 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr1_-_216978708 0.310 NM_001243514
ESRRG
estrogen-related receptor gamma
chr22_+_32753853 0.309 NM_001098535
RFPL3
ret finger protein-like 3
chr7_+_74508346 0.308 NM_001003795
GTF2IRD2B
GTF2IRD2
GTF2I repeat domain containing 2B
GTF2I repeat domain containing 2
chr12_-_53558276 0.304 NM_001244706
CSAD
cysteine sulfinic acid decarboxylase
chr4_+_39408472 0.296 NM_175737
KLB
klotho beta
chr2_-_190627923 0.294 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr3_+_46283871 0.288 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr11_+_5641173 0.286 NM_001003827
TRIM34
tripartite motif containing 34
chr5_+_43609261 0.285 NNT
nicotinamide nucleotide transhydrogenase
chr7_+_2598611 0.283 NM_001100390
NM_152558
IQCE

IQ motif containing E

chr19_-_46526555 0.282 NM_005091
PGLYRP1
peptidoglycan recognition protein 1
chr4_+_170581212 0.282 NM_001243374
CLCN3
chloride channel 3
chr22_-_17302555 0.282 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr11_-_6462129 0.278 NM_000613
HPX
hemopexin
chr21_-_35884503 0.274 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr12_-_54778456 0.272 NM_015481
ZNF385A
zinc finger protein 385A
chr12_+_62954275 0.270 MON2
MON2 homolog (S. cerevisiae)
chr7_-_74267824 0.267 NM_173537
GTF2IRD2B
GTF2IRD2
GTF2I repeat domain containing 2B
GTF2I repeat domain containing 2
chr6_+_26365397 0.267 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr17_+_65936590 0.264 BPTF
bromodomain PHD finger transcription factor
chr16_-_3627353 0.263 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr15_-_55800431 0.262 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1



Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.