Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.544


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARNThg19_v1_chr1_-_150849043_150849061-0.775.4e-16Click!
ARNT2hg19_v1_chr15_+_80733579_807336310.199.5e-02Click!
AHRhg19_v1_chr7_+_17382900_173829130.199.5e-02Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_89745753 14.222 DUSP6
dual specificity phosphatase 6
chr15_-_75932509 13.464 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr22_+_42372763 13.224 NM_019106
NM_145733
SEPT3

septin 3

chr11_+_66790815 12.331 NM_177963
SYT12
synaptotagmin XII
chr1_+_1407112 12.261 ATAD3B
ATPase family, AAA domain containing 3B
chr1_-_205649616 12.105 NM_033102
SLC45A3
solute carrier family 45, member 3
chr1_+_1407158 11.813 NM_031921
ATAD3B
ATPase family, AAA domain containing 3B
chr13_+_28494136 11.143 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr1_+_210406194 11.113 NM_019605
SERTAD4
SERTA domain containing 4
chr16_+_69139466 11.048 NM_001199280
HAS3
hyaluronan synthase 3
chr4_+_156588811 10.411 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr12_-_45270071 10.275 NELL2
NEL-like 2 (chicken)
chr1_-_205649537 10.084 SLC45A3
solute carrier family 45, member 3
chr12_-_76424474 9.934 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr19_+_45909466 9.504 NM_012099
CD3EAP
CD3e molecule, epsilon associated protein
chr6_+_43738757 9.456 VEGFA
vascular endothelial growth factor A
chr1_-_223537400 8.691 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr6_+_73331808 8.637 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr5_-_141704575 8.598 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr1_+_162531349 8.557 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chrX_+_37431015 8.421 LANCL3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr5_-_141704468 8.411 SPRY4
sprouty homolog 4 (Drosophila)
chr17_-_41623246 8.358 NM_001986
ETV4
ets variant 4
chr12_-_45270157 8.262 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr3_-_50374875 8.254 NM_170713
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr5_+_151151462 8.245 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr1_+_1447537 8.194 ATAD3A
ATAD3B
ATPase family, AAA domain containing 3A
ATPase family, AAA domain containing 3B
chr5_+_151151514 8.159 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr6_+_126070813 8.103 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr15_-_79383080 8.021 NM_001145648
NM_002891
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr1_+_1447495 8.014 NM_001170535
NM_018188
ATAD3A

ATPase family, AAA domain containing 3A

chr3_+_14444062 7.867 SLC6A6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr3_-_185826748 7.816 NM_004454
ETV5
ets variant 5
chr1_+_161494035 7.704 NM_002155
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr6_-_107435635 7.646 NM_001080450
BEND3
BEN domain containing 3
chr3_-_62359189 7.595 NM_018008
FEZF2
FEZ family zinc finger 2
chr19_+_17666502 7.568 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr5_+_151151516 7.500 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr1_+_1407157 7.455


chr3_-_50374795 7.387 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr18_+_47088400 7.387 NM_006033
LIPG
lipase, endothelial
chr1_+_1447871 7.372 NM_001170536
ATAD3A
ATPase family, AAA domain containing 3A
chr5_-_172755195 7.297 STC2
stanniocalcin 2
chr16_+_22825806 7.221 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr6_-_43543600 7.193 XPO5
exportin 5
chr6_-_43543749 7.187 XPO5
exportin 5
chr2_+_113403433 7.165 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr17_-_41623652 7.077 NM_001079675
ETV4
ets variant 4
chr2_-_33824294 6.976 NM_015475
FAM98A
family with sequence similarity 98, member A
chr6_-_43543767 6.968 NM_020750
XPO5
exportin 5
chr19_+_17666381 6.961 GLT25D1
glycosyltransferase 25 domain containing 1
chr9_-_140196702 6.882 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr16_+_82660573 6.867 CDH13
cadherin 13, H-cadherin (heart)
chr7_+_70231163 6.853 AUTS2
autism susceptibility candidate 2
chr5_+_151151483 6.812 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr11_-_128392061 6.809 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr19_+_17666457 6.778 GLT25D1
glycosyltransferase 25 domain containing 1
chr5_+_151151511 6.725 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_-_172755418 6.654 STC2
stanniocalcin 2
chr16_+_82660641 6.641 CDH13
cadherin 13, H-cadherin (heart)
chr7_+_24612714 6.620 NM_016447
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr5_-_134914447 6.493 CXCL14
chemokine (C-X-C motif) ligand 14
chr8_+_31497267 6.430 NM_013962
NRG1
neuregulin 1
chrX_-_142722869 6.402 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr11_-_2950593 6.277 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr10_-_35930357 6.254 NM_031866
FZD8
frizzled family receptor 8
chr5_+_176873795 6.212 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr19_-_663219 6.199 NM_194460
RNF126
ring finger protein 126
chr8_+_120428551 6.193 NM_002514
NOV
nephroblastoma overexpressed gene
chr3_+_67048726 6.177 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr12_-_45269953 6.114 NELL2
NEL-like 2 (chicken)
chr3_-_45267068 6.094 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr2_+_219575507 6.090 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr11_+_94277566 6.085 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr12_+_66218879 6.084 HMGA2
high mobility group AT-hook 2
chr5_-_159739482 6.055 NM_024565
CCNJL
cyclin J-like
chr6_+_73331570 6.045 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr19_-_663158 5.993 RNF126
ring finger protein 126
chr12_+_104359557 5.958 NM_003211
TDG
thymine-DNA glycosylase
chr1_+_162531229 5.909 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr5_-_154317653 5.896 NM_001252156
NM_015465
GEMIN5

gem (nuclear organelle) associated protein 5

chr20_-_1165116 5.874 NM_018354
TMEM74B
transmembrane protein 74B
chr6_+_73331992 5.866 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chrX_-_128788913 5.861 NM_017413
APLN
apelin
chr19_-_663155 5.796 RNF126
ring finger protein 126
chr2_+_219575684 5.782 TTLL4
tubulin tyrosine ligase-like family, member 4
chr19_-_663195 5.724 RNF126
ring finger protein 126
chr1_+_110753910 5.704 KCNC4
potassium voltage-gated channel, Shaw-related subfamily, member 4
chr12_-_76425207 5.701 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_+_12391728 5.691 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr3_-_50374749 5.685 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr18_+_43913906 5.676 RNF165
ring finger protein 165
chr8_-_29206321 5.597 NM_057158
DUSP4
dual specificity phosphatase 4
chr20_-_10654429 5.494 NM_000214
JAG1
jagged 1
chr13_+_37006408 5.479 NM_001111045
NM_003914
CCNA1

cyclin A1

chr3_-_170626425 5.452 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr19_-_7968426 5.449


chr11_+_73087670 5.415 NM_032871
RELT
RELT tumor necrosis factor receptor
chr17_+_40719130 5.409 MLX
MAX-like protein X
chr12_+_66218568 5.378 HMGA2
high mobility group AT-hook 2
chr7_-_44365019 5.304 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr13_+_51796363 5.290 NM_001242312
NM_145019
FAM124A

family with sequence similarity 124A

chr3_-_52090090 5.276 NM_001947
DUSP7
dual specificity phosphatase 7
chr7_+_121513158 5.259 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr12_-_58159386 5.254 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr12_-_45269340 5.209 NM_001145109
NELL2
NEL-like 2 (chicken)
chr15_-_79382839 5.085 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr10_+_12391708 5.081 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr17_-_41622727 5.041 ETV4
ets variant 4
chr19_+_56879687 5.000 ZNF542
zinc finger protein 542
chr2_+_206547131 4.999 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr16_-_31214054 4.985 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chr17_+_60705042 4.964 MRC2
mannose receptor, C type 2
chr16_+_22825481 4.963 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr9_-_128003615 4.963 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr3_-_170626381 4.960 EIF5A2
eukaryotic translation initiation factor 5A2
chr8_-_103667882 4.957 NM_005655
KLF10
Kruppel-like factor 10
chr22_+_45098046 4.944 NM_181333
PRR5
proline rich 5 (renal)
chr6_+_126070724 4.907 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr16_-_4322695 4.889 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr3_+_14444083 4.854 NM_001134367
NM_001134368
NM_003043
SLC6A6


solute carrier family 6 (neurotransmitter transporter, taurine), member 6


chr6_-_86352982 4.845 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr3_-_185826332 4.826 ETV5
ets variant 5
chr13_-_21476895 4.822 NM_022459
XPO4
exportin 4
chr16_-_31214003 4.821 PYCARD
PYD and CARD domain containing
chr5_+_89770680 4.814 NM_006467
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr8_+_67341244 4.811 NM_015169
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr1_+_2518464 4.810 FAM213B
family with sequence similarity 213, member B
chr12_+_103351451 4.784 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr9_+_33025302 4.750 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr2_+_220283098 4.740 NM_001927
DES
desmin
chr12_+_4382882 4.736 NM_001759
CCND2
cyclin D2
chr13_+_37005966 4.734 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr7_-_150924220 4.702 NM_005692
NM_007189
ABCF2

ATP-binding cassette, sub-family F (GCN20), member 2

chr11_-_61348290 4.689 NM_001252065
NM_004200
SYT7

synaptotagmin VII

chr6_+_126070738 4.686 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr12_-_28122884 4.683 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr9_-_128003348 4.667 HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr10_+_105156430 4.654 PDCD11
programmed cell death 11
chr17_-_16472463 4.630 NM_020653
ZNF287
zinc finger protein 287
chr6_-_86352635 4.617 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_+_110753313 4.598 NM_001039574
NM_004978
KCNC4

potassium voltage-gated channel, Shaw-related subfamily, member 4

chr19_+_4909447 4.579 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr9_+_33025270 4.545 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr17_+_54671059 4.522 NM_005450
NOG
noggin
chr15_-_63673918 4.504 CA12
carbonic anhydrase XII
chr10_+_105156415 4.490 PDCD11
programmed cell death 11
chr12_-_49365545 4.433 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr3_-_45267620 4.432 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr17_-_38256548 4.424 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr11_+_129245834 4.406 NM_003658
BARX2
BARX homeobox 2
chr16_-_4323000 4.395 NM_003223
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr17_-_56084514 4.389 SRSF1
serine/arginine-rich splicing factor 1
chr1_+_27719151 4.378 NM_005281
GPR3
G protein-coupled receptor 3
chr1_+_221052845 4.353 HLX
H2.0-like homeobox
chr15_-_63674074 4.349 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chrX_-_17879355 4.341 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr1_+_92495484 4.324 NM_173567
EPHX4
epoxide hydrolase 4
chr1_+_9648931 4.324 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr10_-_92617670 4.323 NM_000872
NM_019859
NM_019860
HTR7


5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)


chr10_+_105156382 4.293 NM_014976
PDCD11
programmed cell death 11
chr14_+_103800678 4.247 EIF5
eukaryotic translation initiation factor 5
chr1_+_2518071 4.230 NM_001195736
NM_001195737
NM_001195738
NM_001195740
NM_001195741
NM_152371
FAM213B





family with sequence similarity 213, member B





chr3_-_127541975 4.226 NM_001003794
MGLL
monoglyceride lipase
chr20_-_22564893 4.225 FOXA2
forkhead box A2
chr16_-_4323055 4.196 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr5_-_134914968 4.175 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr20_-_31172874 4.171 LOC284804
uncharacterized LOC284804
chr1_+_221053000 4.164 HLX
H2.0-like homeobox
chr16_+_3019341 4.147 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr20_+_48599511 4.139 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr13_+_37006628 4.133 CCNA1
cyclin A1
chr18_+_55019720 4.110 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr19_-_40732563 4.104 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr7_-_22539795 4.084 NM_001164460
NM_207342
STEAP1B

STEAP family member 1B

chr18_+_77155966 4.080 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr5_-_6633347 4.072 NM_001193455
NM_017755
NSUN2

NOP2/Sun domain family, member 2

chr15_+_38544119 4.064 SPRED1
sprouty-related, EVH1 domain containing 1
chr17_-_38256905 4.052 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr1_+_41249479 4.048 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr3_-_184870727 4.044 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chrX_+_153991106 4.028 DKC1
dyskeratosis congenita 1, dyskerin
chr6_-_86352656 4.024 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr9_+_99212379 4.019 NM_014282
HABP4
hyaluronan binding protein 4
chr7_+_121513210 4.012 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr12_+_110152186 4.010 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr19_-_36980336 4.001 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chrX_-_63425484 3.968 NM_152424
FAM123B
family with sequence similarity 123B
chr6_-_86352650 3.964 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr19_-_10341947 3.963 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr16_-_15188089 3.944 NM_018427
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr17_-_56084498 3.944


chr17_+_40719064 3.943 NM_170607
NM_198204
NM_198205
MLX


MAX-like protein X


chr6_-_86352564 3.939 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr18_+_23806385 3.931 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr2_-_160761192 3.924 LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr14_-_69445989 3.908 ACTN1
actinin, alpha 1
chr14_-_69446038 3.887 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr17_+_65373362 3.886 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chrX_+_37430821 3.884 NM_001170331
NM_198511
LANCL3

LanC lantibiotic synthetase component C-like 3 (bacterial)


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.64 4.84e-11 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.81 7.22e-11 GO:0010467 gene expression
1.56 3.32e-10 GO:0034641 cellular nitrogen compound metabolic process
1.54 7.25e-10 GO:0006807 nitrogen compound metabolic process
1.43 2.00e-09 GO:0044260 cellular macromolecule metabolic process
1.86 3.58e-09 GO:0007399 nervous system development
1.17 4.47e-09 GO:0009987 cellular process
1.77 4.53e-09 GO:0016070 RNA metabolic process
1.66 7.68e-09 GO:0090304 nucleic acid metabolic process
2.06 8.19e-08 GO:0022008 neurogenesis
1.44 3.90e-07 GO:0031323 regulation of cellular metabolic process
1.29 4.99e-07 GO:0044237 cellular metabolic process
1.40 1.30e-06 GO:0019222 regulation of metabolic process
2.01 1.34e-06 GO:0048699 generation of neurons
1.44 1.82e-06 GO:0060255 regulation of macromolecule metabolic process
1.42 3.25e-06 GO:0080090 regulation of primary metabolic process
1.33 5.48e-06 GO:0043170 macromolecule metabolic process
1.66 6.59e-06 GO:0034645 cellular macromolecule biosynthetic process
1.64 1.41e-05 GO:0009059 macromolecule biosynthetic process
2.84 1.45e-05 GO:0045596 negative regulation of cell differentiation
1.50 1.53e-05 GO:0010468 regulation of gene expression
1.56 2.07e-05 GO:0030154 cell differentiation
2.00 2.44e-05 GO:2000026 regulation of multicellular organismal development
1.86 3.05e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.90 3.76e-05 GO:0006351 transcription, DNA-dependent
1.54 4.46e-05 GO:0048869 cellular developmental process
1.66 4.99e-05 GO:0009653 anatomical structure morphogenesis
1.46 5.70e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.71 5.87e-05 GO:0051239 regulation of multicellular organismal process
1.23 7.19e-05 GO:0050794 regulation of cellular process
1.25 1.16e-04 GO:0044238 primary metabolic process
2.01 1.19e-04 GO:0045595 regulation of cell differentiation
1.41 1.31e-04 GO:0048856 anatomical structure development
1.48 1.31e-04 GO:0044249 cellular biosynthetic process
2.51 1.49e-04 GO:0051093 negative regulation of developmental process
1.43 1.96e-04 GO:0048731 system development
1.83 2.05e-04 GO:0050793 regulation of developmental process
1.35 2.15e-04 GO:0032502 developmental process
1.37 2.40e-04 GO:0007275 multicellular organismal development
2.50 2.45e-04 GO:0060284 regulation of cell development
1.21 2.58e-04 GO:0050789 regulation of biological process
1.68 2.67e-04 GO:0009893 positive regulation of metabolic process
1.22 3.25e-04 GO:0008152 metabolic process
1.43 3.31e-04 GO:0051171 regulation of nitrogen compound metabolic process
2.36 4.01e-04 GO:0007420 brain development
1.99 4.29e-04 GO:0006396 RNA processing
1.42 5.49e-04 GO:0009889 regulation of biosynthetic process
2.21 5.74e-04 GO:0032583 regulation of gene-specific transcription
1.42 6.27e-04 GO:0031326 regulation of cellular biosynthetic process
1.44 7.02e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.68 7.15e-04 GO:0031325 positive regulation of cellular metabolic process
3.00 7.67e-04 GO:0030900 forebrain development
1.46 8.55e-04 GO:0051252 regulation of RNA metabolic process
1.41 9.74e-04 GO:0048518 positive regulation of biological process
1.43 9.85e-04 GO:0009058 biosynthetic process
2.29 1.25e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.44 1.29e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.04 1.37e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.07 1.50e-03 GO:0007417 central nervous system development
1.93 1.51e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
2.14 1.60e-03 GO:0008283 cell proliferation
1.19 1.64e-03 GO:0065007 biological regulation
13.75 1.68e-03 GO:0021892 cerebral cortex GABAergic interneuron differentiation
1.95 2.33e-03 GO:0010629 negative regulation of gene expression
2.00 2.60e-03 GO:0051253 negative regulation of RNA metabolic process
1.72 3.03e-03 GO:0032774 RNA biosynthetic process
1.92 3.30e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.92 3.73e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.80 4.31e-03 GO:0051168 nuclear export
9.87 4.61e-03 GO:0021895 cerebral cortex neuron differentiation
1.41 5.54e-03 GO:0048522 positive regulation of cellular process
1.90 5.57e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.84 5.95e-03 GO:0009890 negative regulation of biosynthetic process
1.84 5.95e-03 GO:0030182 neuron differentiation
1.31 6.05e-03 GO:0023052 signaling
1.85 6.10e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.62 7.48e-03 GO:0010604 positive regulation of macromolecule metabolic process
2.47 8.13e-03 GO:0050767 regulation of neurogenesis
1.40 1.04e-02 GO:0048519 negative regulation of biological process
2.34 1.37e-02 GO:0051960 regulation of nervous system development
1.72 1.38e-02 GO:0009891 positive regulation of biosynthetic process
2.70 1.53e-02 GO:0006913 nucleocytoplasmic transport
1.31 1.57e-02 GO:0071840 cellular component organization or biogenesis
2.67 1.89e-02 GO:0051169 nuclear transport
1.68 2.11e-02 GO:0010605 negative regulation of macromolecule metabolic process
2.07 2.39e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.70 2.72e-02 GO:0031328 positive regulation of cellular biosynthetic process
3.67 2.76e-02 GO:0002576 platelet degranulation
1.30 3.65e-02 GO:0051179 localization
2.19 4.12e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.63 4.18e-02 GO:0042127 regulation of cell proliferation
1.40 4.18e-02 GO:0048523 negative regulation of cellular process
1.59 4.50e-02 GO:0010646 regulation of cell communication
1.72 4.71e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.90 4.87e-02 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.68 1.13e-11 GO:0031974 membrane-enclosed lumen
1.78 2.12e-11 GO:0031981 nuclear lumen
1.37 4.29e-11 GO:0005634 nucleus
1.67 6.47e-11 GO:0043233 organelle lumen
1.67 1.36e-10 GO:0070013 intracellular organelle lumen
1.66 7.44e-10 GO:0044428 nuclear part
1.20 9.96e-07 GO:0043231 intracellular membrane-bounded organelle
1.73 1.17e-06 GO:0005654 nucleoplasm
1.14 1.20e-06 GO:0005622 intracellular
1.20 1.22e-06 GO:0043227 membrane-bounded organelle
1.14 2.76e-06 GO:0044424 intracellular part
2.23 3.35e-06 GO:0005730 nucleolus
1.16 2.48e-05 GO:0043229 intracellular organelle
1.16 3.42e-05 GO:0043226 organelle
1.25 1.69e-04 GO:0044446 intracellular organelle part
1.24 2.72e-04 GO:0044422 organelle part
1.37 1.74e-02 GO:0005829 cytosol
1.76 4.28e-02 GO:0030529 ribonucleoprotein complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.25 1.38e-07 GO:0005515 protein binding
1.56 1.44e-07 GO:0000166 nucleotide binding
1.95 2.05e-06 GO:0003723 RNA binding
1.42 2.17e-06 GO:0003676 nucleic acid binding
1.13 8.29e-06 GO:0005488 binding
1.77 3.39e-05 GO:0030528 transcription regulator activity
1.78 4.26e-05 GO:0001071 nucleic acid binding transcription factor activity
1.78 4.26e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 3.63e-04 GO:0017076 purine nucleotide binding
1.49 4.31e-04 GO:0032553 ribonucleotide binding
1.49 4.31e-04 GO:0032555 purine ribonucleotide binding
1.48 7.44e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.80 2.90e-03 GO:0043565 sequence-specific DNA binding
1.47 8.11e-03 GO:0030554 adenyl nucleotide binding
1.47 1.02e-02 GO:0032559 adenyl ribonucleotide binding
2.08 1.97e-02 GO:0016563 transcription activator activity
1.45 2.11e-02 GO:0005524 ATP binding
6.76 2.28e-02 GO:0043022 ribosome binding