Motif ID: AAGGUGC

Z-value: 0.773


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a MIMAT0000072
hsa-miR-18b MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_11382501 7.935 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_132272311 6.416 NM_001901
CTGF
connective tissue growth factor
chr22_-_30642683 6.283 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_-_111136407 4.930 NM_015076
CDK19
cyclin-dependent kinase 19
chr6_+_138188352 4.440 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_+_40834571 4.088 NM_003632
CNTNAP1
contactin associated protein 1
chr6_-_11232901 3.413 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr2_+_28615771 3.262 NM_005253
FOSL2
FOS-like antigen 2
chr15_-_60884615 3.180 NM_134262
RORA
RAR-related orphan receptor A
chr16_+_30960377 3.131 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chr3_-_124774735 3.123 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr5_+_31799030 2.957 NM_178140
PDZD2
PDZ domain containing 2
chr3_+_107241782 2.835 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr11_+_109964086 2.787 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr6_+_152128685 2.475 NM_000125
ESR1
estrogen receptor 1
chr11_-_108464344 2.445 NM_015065
EXPH5
exophilin 5
chr15_-_56285732 2.362 NM_006154
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr15_-_34610928 2.333 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr15_-_34629044 2.305 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr4_-_186732208 2.290 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186732047 2.115 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186733372 2.113 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_+_152011630 2.075 NM_001122742
ESR1
estrogen receptor 1
chr6_-_16761600 1.981 NM_000332
NM_001128164
ATXN1

ataxin 1

chr6_+_152128453 1.922 NM_001122740
ESR1
estrogen receptor 1
chr15_-_60919642 1.893 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr15_-_34630203 1.885 NM_001042495
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr4_-_186697065 1.870 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr6_+_112408673 1.823 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr5_-_142783975 1.759 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr4_-_186578122 1.672 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr1_-_204329043 1.632 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr5_-_59064437 1.579 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_34742656 1.539 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr15_-_34629941 1.524 NM_001042494
NM_001042496
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr10_+_111765725 1.516 NM_019903
ADD3
adducin 3 (gamma)
chr20_+_34700257 1.514 NM_177996
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_+_152126807 1.452 NM_001122741
ESR1
estrogen receptor 1
chr4_+_183245136 1.435 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr10_+_111767685 1.426 NM_001121
NM_016824
ADD3

adducin 3 (gamma)

chr1_-_156470506 1.374 NM_005920
MEF2D
myocyte enhancer factor 2D
chr12_+_11802726 1.366 NM_001987
ETV6
ets variant 6
chr5_-_142815076 1.324 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr13_-_77601296 1.310 NM_012158
FBXL3
F-box and leucine-rich repeat protein 3
chr11_-_16424391 1.306 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr8_-_18666295 1.298 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr6_-_119031230 1.297 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr4_-_186877869 1.295 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr2_-_145277879 1.269 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr5_-_142783225 1.258 NM_000176
NM_001020825
NM_001024094
NM_001204258
NM_001204259
NM_001204260
NM_001204261
NM_001204262
NM_001204263
NM_001204264
NM_001204265
NR3C1










nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)










chr11_+_108093558 1.199 NM_000051
ATM
ataxia telangiectasia mutated
chr15_-_56209305 1.151 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr6_+_19837599 1.096 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr3_+_37903643 1.071 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr3_+_105085553 1.039 NM_001243280
NM_001243281
NM_001243283
NM_001627
ALCAM



activated leukocyte cell adhesion molecule



chr5_-_59783885 1.027 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_100286869 1.010 NM_022574
GIGYF1
GRB10 interacting GYF protein 1
chr1_+_87794150 1.009 NM_006769
LMO4
LIM domain only 4
chr12_+_12764755 1.001 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr4_-_42658883 0.984 NM_001105529
NM_006095
ATP8A1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

chr1_+_172502291 0.967 NM_016227
C1orf9
chromosome 1 open reading frame 9
chr17_-_7382943 0.967 NM_001128833
ZBTB4
zinc finger and BTB domain containing 4
chr18_+_55888750 0.957 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_36583369 0.951 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr8_+_142432006 0.945 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr3_+_42695175 0.930 NM_145166
ZBTB47
zinc finger and BTB domain containing 47
chr1_+_167189948 0.909 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr11_-_16430425 0.906 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr4_-_185395616 0.904 NM_002199
IRF2
interferon regulatory factor 2
chr1_+_173684061 0.885 NM_014458
KLHL20
kelch-like 20 (Drosophila)
chrX_+_108779009 0.863 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr22_+_38092994 0.841 NM_001039141
TRIOBP
TRIO and F-actin binding protein
chr1_+_172502012 0.838 NM_014283
C1orf9
chromosome 1 open reading frame 9
chr16_+_85061303 0.807 NM_014732
KIAA0513
KIAA0513
chr18_+_55714457 0.806 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr21_-_18985224 0.796 NM_001130914
NM_006806
BTG3

BTG family, member 3

chr20_+_49348050 0.792 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr18_+_55816546 0.792 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr18_+_55862577 0.788 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_96338671 0.788 NM_005392
PHF2
PHD finger protein 2
chr11_-_16497917 0.778 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr22_+_40573879 0.763 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr9_+_116638544 0.759 NM_133374
ZNF618
zinc finger protein 618
chr19_-_36523770 0.740 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr12_-_56583301 0.737 NM_001130420
NM_003075
NM_139067
SMARCC2


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2


chr18_+_55711388 0.725 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr11_-_79151694 0.724 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr6_+_39760772 0.718 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_122720685 0.715 NM_001135564
NM_001243094
NM_004506
HSF2


heat shock transcription factor 2


chrX_+_108780235 0.704 NM_001242618
NXT2
nuclear transport factor 2-like export factor 2
chr9_-_123639566 0.679 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr11_-_72852957 0.674 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr7_+_94536926 0.669 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr8_-_18871163 0.666 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr15_-_61521478 0.652 NM_134261
RORA
RAR-related orphan receptor A
chr14_+_103592663 0.632 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr1_-_182361311 0.625 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr7_-_64451413 0.619 NM_015852
ZNF117
zinc finger protein 117
chr3_+_152017193 0.609 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr11_-_130184459 0.606 NM_014155
ZBTB44
zinc finger and BTB domain containing 44
chr19_-_36523540 0.606 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr9_-_132805456 0.605 NM_015033
FNBP1
formin binding protein 1
chr3_+_190105660 0.605 NM_006580
CLDN16
claudin 16
chr19_+_3572903 0.583 NM_006339
HMG20B
high mobility group 20B
chr1_-_11866079 0.582 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_-_151066492 0.576 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr5_-_137071703 0.572 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr1_-_182360400 0.566 NM_001033056
GLUL
glutamate-ammonia ligase
chr10_+_38299525 0.563 NM_006954
NM_006974
ZNF33A

zinc finger protein 33A

chrX_+_108780058 0.561 NM_001242617
NXT2
nuclear transport factor 2-like export factor 2
chrX_-_65835845 0.556 NM_001242310
EDA2R
ectodysplasin A2 receptor
chr16_+_85646923 0.554 NM_014615
KIAA0182
KIAA0182
chr6_-_118973019 0.548 NM_001042475
NM_206921
CEP85L

centrosomal protein 85kDa-like

chr17_+_26698986 0.547 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr16_+_85645014 0.543 NM_001134473
KIAA0182
KIAA0182
chr10_-_119805673 0.534 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr3_+_151985828 0.532 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr18_-_32870143 0.532 NM_001112734
NM_001166012
ZSCAN30

zinc finger and SCAN domain containing 30

chr16_+_77822400 0.527 NM_020927
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like
chr2_+_85198176 0.527 NM_020122
KCMF1
potassium channel modulatory factor 1
chr1_+_43291230 0.525 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr11_-_123525300 0.519 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr4_+_142557722 0.516 NM_000585
NM_172175
IL15

interleukin 15

chr20_+_13202417 0.515 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr17_-_7387513 0.514 NM_020899
ZBTB4
zinc finger and BTB domain containing 4
chr12_-_12715244 0.509 NM_030640
DUSP16
dual specificity phosphatase 16
chr5_-_171710794 0.501 NM_152277
UBTD2
ubiquitin domain containing 2
chr2_+_201997687 0.494 NM_001202518
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_+_202004997 0.490 NM_001202515
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_182880463 0.484 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr1_+_181002560 0.480 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chrX_-_65858882 0.479 NM_021783
EDA2R
ectodysplasin A2 receptor
chr4_-_164253946 0.476 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr10_+_126630691 0.475 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr17_-_42201009 0.475 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr15_+_39873276 0.471 NM_003246
THBS1
thrombospondin 1
chr2_-_208890207 0.467 NM_001080475
PLEKHM3
pleckstrin homology domain containing, family M, member 3
chr1_+_167298280 0.463 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_+_108814419 0.461 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_+_108308336 0.458 NM_014648
DZIP3
DAZ interacting protein 3, zinc finger
chr14_+_70078309 0.458 NM_014734
KIAA0247
KIAA0247
chr6_+_149068148 0.443 NM_005715
UST
uronyl-2-sulfotransferase
chr18_-_14132426 0.443 NM_145287
ZNF519
zinc finger protein 519
chr7_-_139477437 0.440 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr5_-_160279045 0.436 NM_025153
ATP10B
ATPase, class V, type 10B
chr7_+_94539209 0.432 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr16_-_57219951 0.427 NM_024946
FAM192A
family with sequence similarity 192, member A
chr1_+_145438437 0.425 NM_006472
TXNIP
thioredoxin interacting protein
chr1_+_43282775 0.424 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr4_+_154074269 0.422 NM_001130067
TRIM2
tripartite motif containing 2
chr6_+_26440699 0.421 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr6_+_18387580 0.420 NM_182757
RNF144B
ring finger protein 144B
chr11_-_116968986 0.417 NM_025164
SIK3
SIK family kinase 3
chrX_-_20135015 0.414 NM_001168465
NM_001168466
NM_152780
MAP7D2


MAP7 domain containing 2


chr2_-_153032141 0.414 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr3_+_9975513 0.412 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr8_-_145701717 0.409 NM_003923
FOXH1
forkhead box H1
chrX_-_65859107 0.409 NM_001199687
EDA2R
ectodysplasin A2 receptor
chr4_+_154125589 0.409 NM_015271
TRIM2
tripartite motif containing 2
chr8_-_89339716 0.407 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr5_-_58652671 0.401 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_108745718 0.400 NM_001136258
SGMS2
sphingomyelin synthase 2
chr5_-_59189620 0.397 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_180129245 0.393 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr6_+_52284948 0.391 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr6_-_35656677 0.376 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chr1_+_70820485 0.373 NM_001031693
NM_001036645
NM_001036646
HHLA3


HERV-H LTR-associating 3


chr5_-_58571916 0.373 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_-_20134749 0.366 NM_001168467
MAP7D2
MAP7 domain containing 2
chr15_+_73344824 0.362 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr2_+_205410465 0.361 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr1_-_159825136 0.356 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr4_+_157997181 0.356 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr12_+_19592311 0.354 NM_001114176
NM_153207
AEBP2

AE binding protein 2

chr10_-_60027630 0.352 NM_152230
IPMK
inositol polyphosphate multikinase
chr8_-_23021447 0.351 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr1_-_89530890 0.338 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr6_-_143266283 0.338 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr16_+_89984286 0.336 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr15_+_63569748 0.335 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr2_-_206950895 0.332 NM_017759
INO80D
INO80 complex subunit D
chr17_-_76921453 0.327 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr2_+_201983268 0.320 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr6_-_52441815 0.317 NM_012288
TRAM2
translocation associated membrane protein 2
chr5_-_9546157 0.315 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr19_-_7293876 0.315 NM_000208
NM_001079817
INSR

insulin receptor

chr10_+_94050858 0.315 NM_017824
MARCH5
membrane-associated ring finger (C3HC4) 5
chr21_+_38071990 0.313 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr6_+_39760148 0.308 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr2_-_179343225 0.308 NM_001135212
NM_181342
FKBP7

FK506 binding protein 7

chr2_+_113033146 0.306 NM_198581
ZC3H6
zinc finger CCCH-type containing 6
chr12_-_15038724 0.306 NM_000900
NM_001190839
MGP

matrix Gla protein

chr21_+_45285101 0.305 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr20_-_5093482 0.305 NM_001009923
NM_001009924
NM_001009925
NM_014145
C20orf30



chromosome 20 open reading frame 30



chr17_+_25799024 0.297 NM_014238
KSR1
kinase suppressor of ras 1
chr1_-_156542320 0.296 NM_178229
IQGAP3
IQ motif containing GTPase activating protein 3
chr6_+_30908776 0.294 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr1_-_207205996 0.291 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr19_+_21264952 0.290 NM_182515
ZNF714
zinc finger protein 714
chr16_+_3550916 0.288 NM_015041
CLUAP1
clusterin associated protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.32 7.63e-03 GO:0035295 tube development
3.02 1.35e-02 GO:0010556 regulation of macromolecule biosynthetic process
3.21 1.41e-02 GO:0006355 regulation of transcription, DNA-dependent
5.09 1.58e-02 GO:0006351 transcription, DNA-dependent
2.93 1.92e-02 GO:0010468 regulation of gene expression
3.09 2.16e-02 GO:0051252 regulation of RNA metabolic process
4.59 3.52e-02 GO:0032774 RNA biosynthetic process
2.78 3.66e-02 GO:0009889 regulation of biosynthetic process
3.68 3.76e-02 GO:0009653 anatomical structure morphogenesis
2.89 4.46e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
13.60 1.21e-02 GO:0005938 cell cortex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.81 1.54e-03 GO:0001071 nucleic acid binding transcription factor activity
4.81 1.54e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
5.56 4.32e-03 GO:0043565 sequence-specific DNA binding
1.79 4.56e-03 GO:0005515 protein binding
26.17 1.28e-02 GO:0003707 steroid hormone receptor activity
24.71 1.52e-02 GO:0004879 ligand-dependent nuclear receptor activity