Motif ID: AAAGUGC

Z-value: 1.212


Mature miRNA associated with seed AAAGUGC:

NamemiRBase Accession
hsa-miR-106a MIMAT0000103
hsa-miR-106b MIMAT0000680
hsa-miR-17 MIMAT0000070
hsa-miR-20a MIMAT0000075
hsa-miR-20b MIMAT0001413
hsa-miR-519d MIMAT0002853
hsa-miR-93 MIMAT0000093



Activity profile for motif AAAGUGC.

activity profile for motif AAAGUGC


Sorted Z-values histogram for motif AAAGUGC

Sorted Z-values for motif AAAGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAAGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_22550057 8.445 NM_001199881
EGR3
early growth response 3
chr8_-_22549901 8.391 NM_001199880
EGR3
early growth response 3
chr8_-_22550708 8.137 NM_004430
EGR3
early growth response 3
chr2_-_96811138 7.847 NM_004418
DUSP2
dual specificity phosphatase 2
chr9_+_102584136 7.099 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr15_-_74726258 6.671 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr10_-_64576123 6.666 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64578926 6.537 NM_001136178
EGR2
early growth response 2
chr22_-_30642683 5.817 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr4_+_74606222 5.639 NM_000584
IL8
interleukin 8
chr15_-_74726000 5.396 NM_001146030
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr9_+_5450455 5.315 NM_014143
CD274
CD274 molecule
chr14_-_38064440 5.231 NM_004496
FOXA1
forkhead box A1
chr6_-_89827605 4.882 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr17_+_7743233 4.594 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr19_+_1248548 4.484 NM_177401
MIDN
midnolin
chr17_-_43394326 4.396 NM_003954
MAP3K14
mitogen-activated protein kinase kinase kinase 14
chr18_+_10454620 4.258 NM_153000
APCDD1
adenomatosis polyposis coli down-regulated 1
chr1_-_95007139 4.218 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr8_-_9009050 4.137 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr8_-_9008138 4.118 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr5_-_134914968 3.953 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr20_+_49348050 3.672 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr5_-_141704575 3.652 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr16_+_55512801 3.486 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_152486977 3.390 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr19_+_11200037 3.275 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr4_+_75230856 3.255 NM_001432
EREG
epiregulin
chr2_+_110371887 3.243 NM_023016
ANKRD57
ankyrin repeat domain 57
chr20_-_30795346 3.204 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr1_-_230513390 3.200 NM_024554
PGBD5
piggyBac transposable element derived 5
chr7_-_106301329 3.080 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr7_+_28452143 2.855 NM_182898
CREB5
cAMP responsive element binding protein 5
chr7_+_20370724 2.833 NM_002214
ITGB8
integrin, beta 8
chr7_+_28338939 2.823 NM_182899
CREB5
cAMP responsive element binding protein 5
chr7_+_28475233 2.741 NM_004904
CREB5
cAMP responsive element binding protein 5
chr11_+_118401755 2.702 NM_001144034
NM_001144035
NM_001144036
NM_001144037
NM_001144038
NM_032780
TMEM25





transmembrane protein 25





chr7_+_28725597 2.694 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr2_+_182321618 2.691 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr15_+_65134081 2.604 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2

chr12_-_28122884 2.596 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr18_+_21269528 2.585 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr9_+_5510544 2.545 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr5_+_140254930 2.526 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr14_-_71275732 2.515 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr1_-_150552127 2.460 NM_001197320
NM_021960
NM_182763
MCL1


myeloid cell leukemia sequence 1 (BCL2-related)


chr6_+_36646455 2.396 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr13_+_43148182 2.395 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr10_+_6186758 2.385 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr11_+_19734821 2.330 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr16_-_20911560 2.316 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr6_+_36644236 2.307 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_-_1593149 2.292 NM_004420
DUSP8
dual specificity phosphatase 8
chr10_+_6244839 2.290 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_-_23495347 2.273 NM_001142546
NM_033631
LUZP1

leucine zipper protein 1

chr11_-_57417247 2.258 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr3_-_124774735 2.220 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr2_-_85788644 2.216 NM_000821
NM_001142269
GGCX

gamma-glutamyl carboxylase

chr1_-_234745223 2.204 NM_001077397
NM_182972
IRF2BP2

interferon regulatory factor 2 binding protein 2

chr17_-_17399494 2.198 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr21_-_44846927 2.197 NM_173354
SIK1
salt-inducible kinase 1
chrX_+_105969875 2.189 NM_194463
RNF128
ring finger protein 128
chr11_+_19372270 2.177 NM_001111018
NAV2
neuron navigator 2
chr2_-_151344145 2.116 NM_005168
RND3
Rho family GTPase 3
chr9_+_82186846 2.109 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr8_-_103667882 2.079 NM_005655
KLF10
Kruppel-like factor 10
chr3_-_197476567 2.050 NM_001145642
KIAA0226
KIAA0226
chr12_-_26277807 2.043 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr12_-_28124915 2.028 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr18_+_21452981 2.026 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr8_-_23712297 2.004 NM_003155
STC1
stanniocalcin 1
chr1_+_3607232 1.997 NM_001126240
NM_001126241
NM_001126242
NM_001204189
NM_001204190
NM_001204191
TP73





tumor protein p73





chrX_-_10588458 1.982 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr18_+_55714457 1.959 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_157189040 1.947 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr20_-_9819406 1.866 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr3_-_197463713 1.856 NM_014687
KIAA0226
KIAA0226
chr18_+_55888750 1.850 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_-_103666018 1.830 NM_001032282
KLF10
Kruppel-like factor 10
chr14_+_70346113 1.806 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chrX_+_105937067 1.769 NM_024539
RNF128
ring finger protein 128
chr10_+_30722856 1.762 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr2_-_64881040 1.751 NM_014755
SERTAD2
SERTA domain containing 2
chr16_+_55515468 1.748 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_-_50677238 1.740 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr18_+_55816546 1.734 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chrX_-_10645726 1.720 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr16_-_23160509 1.704 NM_020718
USP31
ubiquitin specific peptidase 31
chr15_+_69706619 1.694 NM_004856
NM_138555
KIF23

kinesin family member 23

chr1_+_3569098 1.688 NM_001204184
NM_001204185
NM_001204186
NM_001204187
NM_001204188
NM_005427
TP73





tumor protein p73





chr4_+_87856152 1.670 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr3_-_9291251 1.662 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr6_-_3445198 1.661 NM_021945
SLC22A23
solute carrier family 22, member 23
chr18_+_55862577 1.659 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_67956136 1.613 NM_004232
SOCS6
suppressor of cytokine signaling 6
chr18_+_55711388 1.588 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr16_-_3493489 1.576 NM_152457
ZNF597
zinc finger protein 597
chr12_+_132379262 1.541 NM_003565
ULK1
unc-51-like kinase 1 (C. elegans)
chr14_+_70078309 1.540 NM_014734
KIAA0247
KIAA0247
chr7_+_86974928 1.536 NM_001143935
NM_001243745
NM_021151
CROT


carnitine O-octanoyltransferase


chr2_+_202899309 1.521 NM_003507
FZD7
frizzled family receptor 7
chr11_+_45868668 1.509 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr6_-_16761600 1.502 NM_000332
NM_001128164
ATXN1

ataxin 1

chr4_+_57774035 1.488 NM_005612
REST
RE1-silencing transcription factor
chrX_-_10544852 1.472 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr11_+_45868956 1.467 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr6_-_3456734 1.459 NM_015482
SLC22A23
solute carrier family 22, member 23
chr18_-_46469118 1.416 NM_001190823
SMAD7
SMAD family member 7
chr17_+_26662547 1.403 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr11_-_108464344 1.399 NM_015065
EXPH5
exophilin 5
chr12_-_93323088 1.399 NM_003566
EEA1
early endosome antigen 1
chr4_+_87928083 1.397 NM_005935
AFF1
AF4/FMR2 family, member 1
chr2_+_228029280 1.388 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr20_-_47894591 1.385 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr18_+_9137560 1.383 NM_001204056
ANKRD12
ankyrin repeat domain 12
chr7_-_98741681 1.375 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr18_+_9136742 1.364 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr7_-_142583260 1.364 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr11_+_121322848 1.358 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_38325224 1.342 NM_005955
MTF1
metal-regulatory transcription factor 1
chr9_-_14398981 1.322 NM_001190738
NFIB
nuclear factor I/B
chr10_-_30348433 1.305 NM_020848
KIAA1462
KIAA1462
chr13_+_93879011 1.285 NM_005708
GPC6
glypican 6
chr12_-_53893195 1.280 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chrX_+_16964730 1.279 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr13_+_43136871 1.269 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr12_-_50616425 1.250 NM_001113547
LIMA1
LIM domain and actin binding 1
chr18_-_46477080 1.248 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr6_-_152957985 1.238 NM_033071
SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_+_57775064 1.217 NM_001193508
REST
RE1-silencing transcription factor
chr6_-_47277646 1.214 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_-_204380903 1.209 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr5_+_140235594 1.198 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr10_+_1102741 1.191 NM_014023
WDR37
WD repeat domain 37
chr18_+_48086402 1.185 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr16_+_9185534 1.178 NM_014117
C16orf72
chromosome 16 open reading frame 72
chr3_+_140950671 1.161 NM_001037172
NM_152282
ACPL2

acid phosphatase-like 2

chr7_-_112430408 1.150 NM_022484
TMEM168
transmembrane protein 168
chr12_-_120315074 1.143 NM_001206999
NM_007174
CIT

citron (rho-interacting, serine/threonine kinase 21)

chr5_+_76011780 1.141 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr6_-_152958533 1.140 NM_182961
SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_14314036 1.128 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr2_+_27193448 1.121 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr13_-_107187312 1.115 NM_004093
EFNB2
ephrin-B2
chr10_-_61469322 1.112 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr10_+_97803064 1.111 NM_001134375
NM_001134376
NM_019084
CCNJ


cyclin J


chr4_-_141677470 1.105 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr10_+_112404104 1.104 NM_001134363
RBM20
RNA binding motif protein 20
chr6_+_158244281 1.100 NM_016224
SNX9
sorting nexin 9
chr7_-_127032717 1.048 NM_176814
ZNF800
zinc finger protein 800
chr2_-_19558371 1.026 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr5_-_9546157 1.009 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr14_-_73360792 1.008 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr3_-_56809594 0.996 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr10_-_61122219 0.977 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr7_-_44924946 0.977 NM_033224
PURB
purine-rich element binding protein B
chr5_+_140165875 0.968 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr1_+_145438437 0.962 NM_006472
TXNIP
thioredoxin interacting protein
chr11_+_109964086 0.957 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr15_+_75287829 0.952 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr5_-_150948504 0.946 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chr4_+_7045142 0.939 NM_152293
TADA2B
transcriptional adaptor 2B
chr4_+_48343502 0.933 NM_020846
SLAIN2
SLAIN motif family, member 2
chr8_-_116681103 0.929 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr19_-_4066739 0.928 NM_015898
ZBTB7A
zinc finger and BTB domain containing 7A
chr15_+_68871285 0.917 NM_006091
CORO2B
coronin, actin binding protein, 2B
chrX_-_10851808 0.913 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_179198814 0.911 NM_001136001
NM_001168236
NM_001168237
NM_001168238
NM_007314
ABL2




v-abl Abelson murine leukemia viral oncogene homolog 2




chr20_+_1875382 0.899 NM_080792
SIRPA
signal-regulatory protein alpha
chr1_+_183605207 0.893 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr16_+_85061303 0.889 NM_014732
KIAA0513
KIAA0513
chr17_-_62502410 0.886 NM_004396
DDX5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr14_-_45431121 0.884 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr15_+_68908878 0.880 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr20_+_1874779 0.877 NM_001040022
SIRPA
signal-regulatory protein alpha
chr5_+_140247767 0.875 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr18_-_46475702 0.874 NM_001190822
SMAD7
SMAD family member 7
chr11_-_18655962 0.863 NM_194285
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr2_+_169312793 0.859 NM_203463
CERS6
ceramide synthase 6
chr11_-_123612324 0.859 NM_003455
ZNF202
zinc finger protein 202
chr4_+_88928797 0.858 NM_000297
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr3_-_57113292 0.858 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr20_+_1875825 0.857 NM_001040023
SIRPA
signal-regulatory protein alpha
chr5_+_140207562 0.856 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr5_+_140180782 0.845 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr10_+_120789227 0.844 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr2_+_74273449 0.837 NM_144993
TET3
tet methylcytosine dioxygenase 3
chr3_-_46037299 0.830 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr5_+_172068188 0.822 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr16_-_67450149 0.819 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr1_+_160336856 0.809 NM_005598
NHLH1
nescient helix loop helix 1
chr4_+_120133764 0.798 NM_019050
USP53
ubiquitin specific peptidase 53
chr6_+_33378772 0.794 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr2_-_145052059 0.783 NM_001006636
GTDC1
glycosyltransferase-like domain containing 1
chr2_-_204399906 0.782 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr5_+_140201221 0.778 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr11_-_8680382 0.776 NM_014818
TRIM66
tripartite motif containing 66
chrX_+_68048792 0.775 NM_004429
EFNB1
ephrin-B1
chr14_-_91526912 0.771 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr9_-_95527002 0.763 NM_001003800
NM_015250
BICD2

bicaudal D homolog 2 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.72 1.22e-05 GO:0050794 regulation of cellular process
2.68 4.88e-05 GO:0048523 negative regulation of cellular process
1.61 5.60e-05 GO:0065007 biological regulation
1.64 6.26e-05 GO:0050789 regulation of biological process
2.52 1.30e-04 GO:0048519 negative regulation of biological process
2.06 3.50e-04 GO:0023052 signaling
2.03 5.16e-04 GO:0032502 developmental process
2.03 2.38e-03 GO:0007275 multicellular organismal development
2.01 4.12e-03 GO:0007165 signal transduction
2.05 5.31e-03 GO:0048856 anatomical structure development
2.70 7.39e-03 GO:0009653 anatomical structure morphogenesis
2.22 8.00e-03 GO:0048522 positive regulation of cellular process
2.10 9.20e-03 GO:0048731 system development
2.72 1.07e-02 GO:0009966 regulation of signal transduction
3.44 2.19e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.07 2.40e-02 GO:0048518 positive regulation of biological process
1.82 2.74e-02 GO:0019222 regulation of metabolic process
2.47 2.99e-02 GO:0023051 regulation of signaling
3.34 3.09e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.86 3.92e-02 GO:0031323 regulation of cellular metabolic process
3.63 4.55e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
32.93 7.39e-04 GO:0004709 MAP kinase kinase kinase activity
15.96 1.92e-03 GO:0004702 receptor signaling protein serine/threonine kinase activity
9.39 5.63e-03 GO:0005057 receptor signaling protein activity
1.43 2.89e-02 GO:0005515 protein binding